Wednesday, October 4, 2017

Youtube daily report w Oct 4 2017

Herb Kressel: Hi.

This is Herb Kressel, Editor of Radiology and welcome to the October 2017 Radiology

podcast.

Today, I'm delighted to be joined by Professor Hildo Lamb who is Professor of Radiology at

the Leiden University in Holland, and who with his colleagues, actually in Leiden and

throughout the Netherlands, wrote a very stimulating paper entitled, "Is Hepatic Triglyceride Content

Associated with Aortic Pulse Wave Velocity and Carotid Intima-Media Thickness?

The Netherlands Epidemiology of Obesity Study."

Welcome, Dr. Lamb.

Thanks for joining us again.

Dr. Lamb: Yeah, thank you for another opportunity.

Dr. Kressel: It's a pleasure.

So, first thing's first.

What exactly is The Netherlands Epidemiology of Obesity Study?

Dr. Lamb: It's a large cohort study that we initiated in 2008, so now almost ten years

ago and we included more than 6,000, it's almost 7,000 patients in total and about one-third

of those patients also had imaging and in that imaging part, we had different randomizations.

One of the randomizations was to image the aorta and the cardiovascular part, but also

some of them were included in the arm to measure the carotid IMT, the intima-media thickness

and lots of other things like blood work, neurologic testing, and all kinds of things

that were not included in this paper, but for this particular topic we ended up with

almost 2,000 patients for the statistical analysis.

Dr. Kessel: Right.

So can you just share with us the specific study rationale?

Why did you target this particular content?

Why would one expect that hepatic triglyceride content should independently be associated

with pulse wave velocity and/or carotid artery intimal wall thickness?

Dr. Lamb: At first this seems a really strange association that you might think, "Well, what

has the liver to do with the cardiovascular system?"

It was actually based on experiments some time ago based on dietary interventions where

we observed sort of co-variants in lipid levels in the liver and normal cardiovascular function

and vessel stiffness and then we developed this concept in the end that we think that

all over in the body the process is more or less the same, like in atherosclerosis.

So first, you may have fat accumulation, then in response you develop inflammatory processes

and based on that you have collagen formation and scarring.

So what we thought maybe that the liver is the central organ in this process and that

the liver actually directs all these changes all over in the body.

So the idea was to study the link between fatty liver and other organs and in this case

we were interested in two separate processes - the vessel stiffness and as a separate process

atherosclerosis by measuring the intima-media thickness by ultrasound.

Dr. Kessel: So blame it all on the liver.

Dr. Lamb: Yeah, maybe that's a good thing to remember.

Dr. Kessel: The liver is the root of all of joy and problems.

Okay.

Very interesting.

So another thing that some of those listening and viewing the podcast may be curious about,

can you tell us a little more about pulse wave velocity alterations in the aorta and

what's the presumed mechanism of this in relation to atherosclerosis and to brain changes as

well?

Dr. Lamb: In general, it's a complicated process.

The name is also difficult, pulse wave velocity, but what it actually means is that we tried

to measure the propagation of the ampules by the heart ejection.

So we do not measure the flow or the flow volume.

It's just measuring how the blood propagates through the aorta and you can compare this

for example by water flowing through a pipe.

If the pipe is very stiff, the transportation time of the water from the pump to the distal

end of the tap is very fast, so the speed of the water is very high and if you have

a more elastic tube like the aorta and when you're young and healthy, then it will be

a little bit dampened and the speed of the fluid is decreased a little bit.

So high pulse wave velocity reflects a stiff pipe and in this case stiff aorta, and the

idea is that this is maybe related to atherosclerosis, but we are not sure if this is really the

cause or effect.

We think that this is related to the balance between the elastin in the vessel wall and

the collagen level and we also know that this ratio is different between the central part

of the arteries and the peripheral arteries.

For example, there is a difference between the central aorta and the peripheral vessels

like the carotid artery where we measured intima-media thickness.

Dr. Kessel: I see.

Very good.

Now, a little more about your study design.

What did you actually do to study your hypothesis and study the associations?

How did you choose the cohort?

Did you have any subjects with elevated triglycerides who were not obese, as this is primarily the

obesity study.

So how did you go about answering the question you asked?

Dr. Lamb: Well, the only major inclusion criteria was to be healthy or that you don't have

a real known cardiovascular disease or diabetic disease, but actually it was a quite open

study.

So also we included normal people with normal BMI and also we had people in the overweight

category between a BMI of 25 and 30, and obesity group with a BMI higher than 30.

And based on the results of blood measurements in the patients, the blood work, we afterwards

corrected the findings.

So for example, we also included the lipid work, the lipid levels, use of lipid lowering

medication, and we used all this data to detect confounding factors in our statistical model.

So actually everybody was welcome in the study and afterwards we were using the statistical

tricks and that is possible because it's a relatively large cohort.

Dr. Kessel: Yes.

So if you can tell us, briefly summarize your key findings.

Dr. Lamb: The key finding is best shown in Figure 2.

That is the easiest way to understand.

So actually what we found is that if you have higher triglyceride content in the liver,

so you have a fatty liver, that also the vessel stiffness or the pulse wave velocity is higher.

Also on the other end of the spectrum, we slowed that with a lower BMI and with low

liver fat, that also your pulse wave velocity is lower.

So this confirms the feeling we had from previous studies and small studies that in this large

cohort we indeed have an association or some sort of statistical link at least between

the fat level in the liver and vessel stiffness.

On the other hand, we also found relation between the carotid intima-media thickness

that was a little bit higher in the patients with higher liver fat.

Then it's always difficult to interpret these statistical numbers, so for the intima-media

thickness it means that in the real world if you have a ten-fold increase in your fat

level in the liver, then a 15 micrometer increase in your intima-media thickness happens.

So that's the way - how you have to interpret these results.

The same is true for the vessel stiffness, for the pulse wave velocity.

So if this fat level in the liver increases ten-fold, then you have about a 0.2 increase

in your meter per second speed of vessel stiffening.

So that's how you can look at these numbers.

Dr. Kessel: Good.

So can you kind of review how you identified this as independent of the other features

of the metabolic syndrome?

Dr. Lamb: Yeah, that's always nice of those larger cohort studies that you can use all

the information you have and run different models.

So what we normally do is start with the crude model, that's usually model 1, also in this

study.

Then we chose to use model 2 to check the confounding effects of general things like

age, sex, blood pressure, heart rate, but also alcohol use, smoking habits, use of antihypertensive

drugs, lipid-lowering drugs.

So that's model 2.

And then on top of that, we were more specifically interested in the factors determining the

metabolic syndrome.

That was model 3.

And in model 4 it was everything and also on top of that the visceral adipose tissue

and the total body fat.

And actually in that model 4 all the factors we could imagine are included there that could

confound the results and even in that situation, we had a significant correlation or association

between the liver fat and the pulse wave velocity and the liver fat and the intima-media thickness

of the carotid arteries.

Dr. Kessel: So are these models basically regression analyses or is it-

Dr. Lamb: No, mainly ANOVA linear analysis.

Dr. Kessel: Very good.

Now one thing I noticed is that you had a - at least it was termed - a high failure

rate in the acquisition of MR spectroscopy, which you used as the metric for hepatic fat,

and with approximately a third of the patients there wasn't usable data.

What do you think this was due to?

Not allocating sufficient time for the exam or some lack of training?

Dr. Lamb: That's an interesting question.

I think it's mainly due to the technical challenges you have to perform spectroscopy studies in

general.

In the liver it's one of the easiest variants of that.

In the heart, for example, it's much more complicated.

So we had a learning curve for the technicians.

That was one factor.

So in the beginning, they missed out a lot of scans because you have to perform it with

and without water suppression and sometimes we had two spectra with water suppression,

two spectra without water suppressions, so that was a problem in the beginning and it

was also a reason why we started developing newer techniques, so now in new studies we

prefer to use the imaging-based Dixon-like techniques where you have a very easy setup

and everybody can do the scan.

Dr. Kessel: I see.

Well, that certainly makes sense.

And you mentioned looking at the lipid-lowering drugs.

What was the effect of these when you kind of analyzed it in the regression models?

Dr. Lamb: Yeah, for the parameters we studied, that actually then - the difference between

model 1 and 2, there was an effect.

The significance of the model went down of the beta actually of the association, but

still it was statistically significant.

So there was an effect, but it did not explain the relation fully between the fatty liver

and the vessel stiffness and the IMT thickness.

Dr. Kessel: Okay.

So they sort of moved down the curve of the response curve if you will.

Dr. Lamb: Yeah.

Dr. Kessel: Okay.

And going forward, what do you think are the potential clinical and public health implications

of your findings other than everyone should control their weight?

Are there other implications?

Dr. Lamb: Yeah, there is one interesting pathophysiological finding that's a little bit more detailed,

but we found a difference between the IMT measurements association because there was

an effect of visceral fat.

Actually, when we included visceral fat in model 4, the relation between the liver fat

and IMT thickness was not significant anymore, but in the vessel stiffness, it didn't matter.

So the significance even got better.

So this may indicate that the pathophysiological process behind atherosclerosis is a little

bit different, different pathway, different factors than the vessel stiffening itself.

On the other hand, if you are very practical, we know from literature and we performed a

couple of those studies before, that there is still hope because if you do a diet, then

also the pulse wave velocity changes.

So it is still reversible if you are in a sort of sweet spot area.

Dr. Kessel: Well, thank you very much.

This is very exciting work and we look forward to seeing the results of your future manuscripts

and thank you so much for joining us today.

Dr. Lamb: Okay.

Thank you very much.

Dr. Kessel: You're welcome.

Bye bye.

Dr. Lamb: Bye bye.

For more infomation >> Hepatic Triglyceride Content Is Associated with Aortic Stiffness - Duration: 14:40.

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The Smothering - Steven Universe Fan episode - Duration: 13:48.

Careful Steven, don't bite down, you'll break the thermometer.

Ah, 98.6, good, nothing to worry about.

Uhh, Peridot. Do we really have to do this everyday? I mean, couldn't we, maybe, do the health check ups - Once a week?

No, this is fine. It's better to gather data as frequently as possible

Y'know Data's not going to stop me from getting sick again.

It's good to be prepared Steven.

Ok but, I just don't want you to waste too much time worrying about me.

*SNORT*

You can't waste time worrying

*WARP PAD ACTIVATES*

We're back

Hey Jasper, hey Lapis!

STEVEN! put that knife down, you'll cut yourself!

Hey guys...

Jasper: Hello Steven Lapis: Hey Steven!

Jasper: Did you sleep well?

Yeah I slept pretty great!

At least until Peridot woke me up again with her health check up

Health checkup? Are you sick?

You don't look sick

No, I'm not sick. Peridot's just been doing health check ups on me everyday since I caught that cold.

You're still doing that?

Yes I'm STILL doing that Jasper. Unlike SOME gems I actually care about Steven's safety.

We all care about Steven Peridot, you're just being overbearing

I AM NOT OVERBEARING!

I'm maternal

Steven, tell her

well you did take my second pillow away, cuz you said it might be...

...dangerous

I was worried about you being smothered in your sleep. Anyway you don't need two.

It was nicer with two though.

For someone so worried about smothering you seem to be doing a lot of it

Lapis: OOOOOoooooohhhhh

*Deep breath*

Jasper.

don't you perhaps have something

HEAVY, you need to be...

MOVING AROUND?

Steven. We're going out now to go on a mission, would you like to come with us?

I can go on the mission?!

Peridot: WHAT!?

*THUMP*

S-Steven can't go on mission! It's too dangerous, he's not ready, he doesn't have any of his powers, he can't-

Jasper: I ASKED! Steven...

Don't worry Steven, we'll be there to protect you.

Yeah Steven come with us, it'll be great!

You'll get to see us fight a giant monster up close!

Perdot: NO HE WON"T! He has to stay at a reasonable distance.

I wanna go on the mission!

Ah, Steven your first mission! You're gonna have so much fun!

Steven & Lapis: *Happy Laughter*

STEVEN WAIT!

You're still wearing your pajamas!

Okey Steven, let's wee here while Jesper and lapis scout ahead that way

We'll always be close to the war pad, and he's anything dangerous happens. Hey Steven come look at this. It's super gross, okay

What is this stuff we don't know it's some kind of slime residue made by the monster we were tracking

It's harmless to us, but it's killing all the plants around here plus. It's totally gross

Lapis don't get that muck away from him there could be

infectious

peridot

Lazuli lapis don't you dare?

Over here

Climb across

Mmm

Stay calm Steven use your arms to balance and walk slowly pearl if you need to

Careful Steven

Stephen when you're in the field

It's important to obtain as much knowledge of the area as possible so though you have the tactical advantage to crush your opponent's

Get on top of that vantage point tell me if you see anything important

What do you see

Well, I can see a lot of things I can see a big lake over that way

There's a bunch of rocks and what looks like more broken pillars up ahead

And then there's what kind of looks like a big clearing where surgeries are falling down

That was close you could have fallen and seriously damaged your cranium at least you were wearing your helmet

Hey, Steven want me to fly you around and look for the monster. Do I great we'll go right now

Peridot what are you? Don't worry peridot? I'll be fine. I'm with lapis whoa

I'm okay

She'll be fine. Oh

Hey, there's another river, and it's filled with gross slime stuff hey that must be where the monster is

Let's go get it whoa

Lapis shouldn't we wait for the others it'll be fine Steven come on it, but it's over here

Lapis I'm not so sure and it even come look lapis

Are you excited Steven if your very first official mission monster isn't it cool?

Yeah, it's pretty cool. Like I guess I just didn't think it would be so

funny

You want to see me beat it up

Okay, sure

Hey, you wanna bubble the gym I can bubble Jones probably try it out

Stephen you did it you bubbled your first gem we should go show Jasper repaired on ok

Hey guys look what Stephen did I bubbled a gym Stephen? You're helpful. Even you

Okay good mission everyone well done Stephen time to go home. Oh

Isn't this better Stephen nice and safe nothing dangerous

Capable of lately preferred in your bio matter you must be so relieved to be home

Well you've had a busy day Stephen time for bed, but it's not even lunchtime yet, Oh Stephen you and your

food

Okay, you can have lunch, but then you have to put on your pajamas and go to bed

Well

Steven

Home Easter Steven. I thought your heart had malfunctioned. Oh, and you spill your milk really Steven

You know better than a meat snacks in the dark

Peridot you don't have to apologize Steven. I'll clean this up, and you can just go back to bed

I'll tuck you in when I'm done

I'm not tired. What was that Steven? I said, I'm not tired are

You upset about your milk Steven, it's okay. We can go down and get you some more tomorrow. I'm not upset about the milk

I'm upset because you wouldn't let me do anything all day even though it was my first mission

and then you maybe go to bed at lunchtime and

It is tomorrow, which is why I'm not tired

Steven I be not so sure I like your tone young man

Stephen you've contaminated your plasma. Oh Stephen Stephen. Where are you going?

Stephen you can't activate the

Even even come back here, you're not even married shoes

Look even what are you doing?

Even please get down from there. It's dangerous keep it on yourself or better yet

Just be still and I'll get you down peridot

Peridot I'm really sorry I scared you. I know that you worry a lot when you think I'm in danger from rocks

Or we're getting sick or being on missions, and I know it's because you care

But you can't always be there to protect me from all that stuff. You need to let me do some things on my own

You okay, buddy

My head hurts

Well you did fall off of rock that

Stephen I

Realizing me a bit a bit

constraining with you lately, so I am going to be making an effort to allow you more freedom to

Learn on your own does this mean you're gonna stop doing health check-ups of course not even you just got concussed

Hmm, but after you get better we can change it to once a week like you wanted oh

Okay, hey can I have my second pillow back?

Cool

My head still hurts

For more infomation >> The Smothering - Steven Universe Fan episode - Duration: 13:48.

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Catch the mother of all news t...

For more infomation >> Catch the mother of all news t...

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Uomini e Donne, accesa lite tra Gemma, Marco e Gianfranco: ecco il motivo | K.N.B.T - Duration: 4:13.

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Grande Fratello Vip, Luca e Soleil in crisi: confessione shock a Pomeriggio 5 - Duration: 3:42.

For more infomation >> Grande Fratello Vip, Luca e Soleil in crisi: confessione shock a Pomeriggio 5 - Duration: 3:42.

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Uomini e Donne, Luca e Soleil: la Sorgè abbandona lo studio del GF, crisi con Onestini - Duration: 3:09.

For more infomation >> Uomini e Donne, Luca e Soleil: la Sorgè abbandona lo studio del GF, crisi con Onestini - Duration: 3:09.

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Ecco cosa è successo tra Signorini e Andrea Damante durante la pubblicità - Duration: 4:20.

For more infomation >> Ecco cosa è successo tra Signorini e Andrea Damante durante la pubblicità - Duration: 4:20.

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Uomini e Donne, Soleil: il retroscena sul Grande Fratello Vip - Duration: 3:49.

For more infomation >> Uomini e Donne, Soleil: il retroscena sul Grande Fratello Vip - Duration: 3:49.

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Uomini e Donne, trono over: grande abbandono in arrivo? - Duration: 3:58.

For more infomation >> Uomini e Donne, trono over: grande abbandono in arrivo? - Duration: 3:58.

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Oggi Uomini e Donne: Gemma sotto accusa, mollata da due uomini - Duration: 3:06.

For more infomation >> Oggi Uomini e Donne: Gemma sotto accusa, mollata da due uomini - Duration: 3:06.

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Grande Fratello Vip: lite accesa tra Jeremias e Simona - Duration: 4:22.

For more infomation >> Grande Fratello Vip: lite accesa tra Jeremias e Simona - Duration: 4:22.

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Peugeot 108 1.0 e-VTi 68pk 5D Active - Duration: 0:56.

For more infomation >> Peugeot 108 1.0 e-VTi 68pk 5D Active - Duration: 0:56.

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Mercedes-Benz E-Klasse 220 D PRESTIGE PLUS AMG STYLE / PANODAK / FABRIEKSGARANTIE - Duration: 1:03.

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QUEM É O MELHOR: MARCELO MADUREIRA OU EDUARDO BUENO? - Duration: 8:44.

For more infomation >> QUEM É O MELHOR: MARCELO MADUREIRA OU EDUARDO BUENO? - Duration: 8:44.

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pozzetto e quella scena nella vasca con la fenech: ci siamo insaponati e... - Duration: 4:20.

For more infomation >> pozzetto e quella scena nella vasca con la fenech: ci siamo insaponati e... - Duration: 4:20.

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Mare e Monti day 6 (6/10) - Duration: 4:01.

leaving the gite

today a short walk to Serriera

first 100 meters up in the village

this is were we ended the trail yesterday

strange marker

nice view the first hour

but also bush paths

from here a detout to Partinello only 15 minutes

No coffee in this village :(

back on trail again

it's really a sunny day today

the last descent today

and now 250 meters down to Serriera

this is a nice village with a shop and snackbar

arrived at gite l'Alivi

tonight we share this clean room with 3 others

For more infomation >> Mare e Monti day 6 (6/10) - Duration: 4:01.

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Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.

HELLO GUYS, A LOT OF PEOPLE ASK ME

ABOUT HAPPINESS AT WORK,

"OH I'M NOT HAPPY DOING

WHAT I'M DOING, MY JOB,

I'M NOT HAPPY". SO I STOP TO THINK

IF THIS PERSON KNOW WHY SHE'S DOING THAT OR

WHAT THE PROPOSE OF HER WORK

WHAT WOULD YOU DO

IF YOU COULD DO SOMETHING FOR FREE ?

AND IT MAKES YOU GLAD,

.....GIVE YOU A BIG PLEASURE....

I THINK THIS IS THE BIG SEARCH

WHEN YOU DO SOMETHING YOU LOVE,

AND SOMETHING THAT THE WORLD NEEDS,

THIS IS YOUR " MISSION "

WHEN YOU REALLY DO SOMETHING THAT THE WORLD NEED,

AND THE WORLD IS ABLE TO PAY YOU FOR THIS

IT'S WHAT I CALLED "VOCATION "

YOU REALIZED WHAT THE WORLD ABLE

TO PAY YOU...

...FOR THIS, AND REALLY MAKE....

...THIS HAPPENED

YOU TURN THIS INTO YOUR " JOB "

AND WHEN YOU ARE DOING

WHAT YOU LOVE, IT'S YOUR "PASSION "

WHEN YOU DISCOVERED YOU " PASSION, MISSION,

....JOB AND VOCATION "

AND FIT IN INTO YOUR LIFE,

YOU REALIZED WHAT IS YOU " GIFT "

THAT IN PORTUGUESE IS " DOM "

WHEN YOU DISCOVERED YOUR GIFT,

YOU ARE FINALLY ABLE TO WORK THE REST

OF YOUR LIFE INTO SOMENTHING YOU...

......LOVE

AND I ENSURE THAT YOU WILL BE...

VERY HAPPY

........

GO TO MY WEBSITE,

THERE'S EVERYTHING THAT I TOLD YOU HERE

AND SUBSCRIBE BECAUSE

REALLY NICE THINGS WILL COME FOR WE THINK TOGETHER

THANKS

For more infomation >> Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.

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ventimila seghe sopra i mari - ieri e' partita la 'sex cruise' ovvero 2.000 scambisti in crociera - Duration: 2:11.

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Afogado nas Lembranças da Cidade - Duration: 11:11.

For more infomation >> Afogado nas Lembranças da Cidade - Duration: 11:11.

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UND Mortar Board Volleyball Fundraiser - Duration: 0:45.

Mortar Board is a senior Honor Society not only on the campus of UND but in

over 200 campuses nationwide.

Thanksgiving is a time for family, food, reflecting on what you're thankful for

and mortarboard would like to help families in the greater Grand Forks area

be able to afford that for some of those who cannot. I chose this particular

volleyball tournament to just get involved with my campus and just have

some fun be a part of the UND community.

Last year alone we gave out 1,200 baskets.

We're hoping to give out even more this year.

For more infomation >> UND Mortar Board Volleyball Fundraiser - Duration: 0:45.

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A Herdeira Tvi - Luz quer saber o que se passa entre o pai e Madalena - 2 Out 2017 - Duration: 5:05.

For more infomation >> A Herdeira Tvi - Luz quer saber o que se passa entre o pai e Madalena - 2 Out 2017 - Duration: 5:05.

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Overview: Report Packages Part I in Oracle Enterprise Performance Reporting Cloud - Duration: 5:20.

In this two-part overview we'll show you

the highlights of report packages.

In part one, we'll discuss what report

packages are, and why to use them, and

we'll discuss their components such as

doclets, sections, and development phases.

Part two examines these development phases

in more detail. Performance reporting is

a critical function in most companies.

Whether the reports are internal reports

for board packages, management updates,

quarterly updates, or external reports

like statutory, regulatory, filing, or

annual, the ability to gather information

from various sources, review it for

accuracy, and present it to the intended

audience is a core function of business.

Creating reports is easy with one author

and no required review, but having

multiple authors working on report can

be more complicated. Do all of the

authors have the current version?

How do you merge changes from multiple

authors into a single document? As you

add content creators, giving everyone

organized becomes more challenging.

The situation can become even more difficult

with several authors, multiple reviewers,

each of whom might be responsible for

different sections, and multiple signers

who provide final sign-off on the whole report.

How do you keep all of your

authors, approvers, reviewers, and signers organized?

How do you handle versioning

and manage workflow?

Coordinating stakeholders by email can

be daunting. A better way to organize and

produce a collaborative report is by

using a report package.

So, what is report package? A report package is a

reporting construct that enables you to

structure the content of your report,

assign responsibilities to content

creators and reviewers, and manage their

collaboration and workflow to produce a

unified document.

Report packages help you manage the

lifecycle of your deliverables.

With them you can assign content to

multiple authors,

gather comments from reviewers, provide

an electronic sign off on the completed

report,

manage the report life cycle by

providing notifications to users

managing the workflow, and coordinating

the processes, combine data points with

textual narrative, and secure and control

access to the report content enabling

users to see only the content that they

are permitted to see, at the time that

they are permitted to see it.

Next, let's look at some key components

of a report package. Report packages

enable you to divide reports into sub

components called doclets. What makes up

a doclet varies depending on the type of

report that you are creating. For example,

a sales report might have separate

doclets for each geographical region, and

a financial disclosure might have

doctorates for each of the various

financial statements, tax statements, and notes.

You assign doclets to authors who

then provide content.

Sections enable you to group doclets for

organization or to keep documents

together that have a common format or

are intended for a common viewership.

For example, you can group all financial

statements in a report into one section.

This provides a filtered view of only

those documents to the reviewers

assigned to that section.

Report package development occurs in

three phases. The author phase enables

you to compile the various report

content and supporting details together

into a cohesive report package.

The review phase allows you to gather

commentary on multiple draft versions

and to revise the report content accordingly.

The sign-off phase provides

the ability to gather electronic

signatures from key stakeholders and to

secure report content to prevent further

modifications. You decide which

development phases your report requires.

Is the report content going to be

provided primarily by one or two people?

Then you may not require an author phase.

Is your report being developed for a

small group of internal stakeholders?

Then you may not require a review phase.

You can tailor the development phases to

the type of report that you require.

In part 1 of this topic we defined report

packages and their components, and we

discuss the many benefits of using them

within your organization. In part two, we

will look at the developmental phases in

a little more detail. To learn more about

Enterprise Performance Reporting Cloud Service,

visit the link shown here.

For more infomation >> Overview: Report Packages Part I in Oracle Enterprise Performance Reporting Cloud - Duration: 5:20.

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Geostorm Movie Trailer

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Hepatic Triglyceride Content Is Associated with Aortic Stiffness - Duration: 14:40.

Herb Kressel: Hi.

This is Herb Kressel, Editor of Radiology and welcome to the October 2017 Radiology

podcast.

Today, I'm delighted to be joined by Professor Hildo Lamb who is Professor of Radiology at

the Leiden University in Holland, and who with his colleagues, actually in Leiden and

throughout the Netherlands, wrote a very stimulating paper entitled, "Is Hepatic Triglyceride Content

Associated with Aortic Pulse Wave Velocity and Carotid Intima-Media Thickness?

The Netherlands Epidemiology of Obesity Study."

Welcome, Dr. Lamb.

Thanks for joining us again.

Dr. Lamb: Yeah, thank you for another opportunity.

Dr. Kressel: It's a pleasure.

So, first thing's first.

What exactly is The Netherlands Epidemiology of Obesity Study?

Dr. Lamb: It's a large cohort study that we initiated in 2008, so now almost ten years

ago and we included more than 6,000, it's almost 7,000 patients in total and about one-third

of those patients also had imaging and in that imaging part, we had different randomizations.

One of the randomizations was to image the aorta and the cardiovascular part, but also

some of them were included in the arm to measure the carotid IMT, the intima-media thickness

and lots of other things like blood work, neurologic testing, and all kinds of things

that were not included in this paper, but for this particular topic we ended up with

almost 2,000 patients for the statistical analysis.

Dr. Kessel: Right.

So can you just share with us the specific study rationale?

Why did you target this particular content?

Why would one expect that hepatic triglyceride content should independently be associated

with pulse wave velocity and/or carotid artery intimal wall thickness?

Dr. Lamb: At first this seems a really strange association that you might think, "Well, what

has the liver to do with the cardiovascular system?"

It was actually based on experiments some time ago based on dietary interventions where

we observed sort of co-variants in lipid levels in the liver and normal cardiovascular function

and vessel stiffness and then we developed this concept in the end that we think that

all over in the body the process is more or less the same, like in atherosclerosis.

So first, you may have fat accumulation, then in response you develop inflammatory processes

and based on that you have collagen formation and scarring.

So what we thought maybe that the liver is the central organ in this process and that

the liver actually directs all these changes all over in the body.

So the idea was to study the link between fatty liver and other organs and in this case

we were interested in two separate processes - the vessel stiffness and as a separate process

atherosclerosis by measuring the intima-media thickness by ultrasound.

Dr. Kessel: So blame it all on the liver.

Dr. Lamb: Yeah, maybe that's a good thing to remember.

Dr. Kessel: The liver is the root of all of joy and problems.

Okay.

Very interesting.

So another thing that some of those listening and viewing the podcast may be curious about,

can you tell us a little more about pulse wave velocity alterations in the aorta and

what's the presumed mechanism of this in relation to atherosclerosis and to brain changes as

well?

Dr. Lamb: In general, it's a complicated process.

The name is also difficult, pulse wave velocity, but what it actually means is that we tried

to measure the propagation of the ampules by the heart ejection.

So we do not measure the flow or the flow volume.

It's just measuring how the blood propagates through the aorta and you can compare this

for example by water flowing through a pipe.

If the pipe is very stiff, the transportation time of the water from the pump to the distal

end of the tap is very fast, so the speed of the water is very high and if you have

a more elastic tube like the aorta and when you're young and healthy, then it will be

a little bit dampened and the speed of the fluid is decreased a little bit.

So high pulse wave velocity reflects a stiff pipe and in this case stiff aorta, and the

idea is that this is maybe related to atherosclerosis, but we are not sure if this is really the

cause or effect.

We think that this is related to the balance between the elastin in the vessel wall and

the collagen level and we also know that this ratio is different between the central part

of the arteries and the peripheral arteries.

For example, there is a difference between the central aorta and the peripheral vessels

like the carotid artery where we measured intima-media thickness.

Dr. Kessel: I see.

Very good.

Now, a little more about your study design.

What did you actually do to study your hypothesis and study the associations?

How did you choose the cohort?

Did you have any subjects with elevated triglycerides who were not obese, as this is primarily the

obesity study.

So how did you go about answering the question you asked?

Dr. Lamb: Well, the only major inclusion criteria was to be healthy or that you don't have

a real known cardiovascular disease or diabetic disease, but actually it was a quite open

study.

So also we included normal people with normal BMI and also we had people in the overweight

category between a BMI of 25 and 30, and obesity group with a BMI higher than 30.

And based on the results of blood measurements in the patients, the blood work, we afterwards

corrected the findings.

So for example, we also included the lipid work, the lipid levels, use of lipid lowering

medication, and we used all this data to detect confounding factors in our statistical model.

So actually everybody was welcome in the study and afterwards we were using the statistical

tricks and that is possible because it's a relatively large cohort.

Dr. Kessel: Yes.

So if you can tell us, briefly summarize your key findings.

Dr. Lamb: The key finding is best shown in Figure 2.

That is the easiest way to understand.

So actually what we found is that if you have higher triglyceride content in the liver,

so you have a fatty liver, that also the vessel stiffness or the pulse wave velocity is higher.

Also on the other end of the spectrum, we slowed that with a lower BMI and with low

liver fat, that also your pulse wave velocity is lower.

So this confirms the feeling we had from previous studies and small studies that in this large

cohort we indeed have an association or some sort of statistical link at least between

the fat level in the liver and vessel stiffness.

On the other hand, we also found relation between the carotid intima-media thickness

that was a little bit higher in the patients with higher liver fat.

Then it's always difficult to interpret these statistical numbers, so for the intima-media

thickness it means that in the real world if you have a ten-fold increase in your fat

level in the liver, then a 15 micrometer increase in your intima-media thickness happens.

So that's the way - how you have to interpret these results.

The same is true for the vessel stiffness, for the pulse wave velocity.

So if this fat level in the liver increases ten-fold, then you have about a 0.2 increase

in your meter per second speed of vessel stiffening.

So that's how you can look at these numbers.

Dr. Kessel: Good.

So can you kind of review how you identified this as independent of the other features

of the metabolic syndrome?

Dr. Lamb: Yeah, that's always nice of those larger cohort studies that you can use all

the information you have and run different models.

So what we normally do is start with the crude model, that's usually model 1, also in this

study.

Then we chose to use model 2 to check the confounding effects of general things like

age, sex, blood pressure, heart rate, but also alcohol use, smoking habits, use of antihypertensive

drugs, lipid-lowering drugs.

So that's model 2.

And then on top of that, we were more specifically interested in the factors determining the

metabolic syndrome.

That was model 3.

And in model 4 it was everything and also on top of that the visceral adipose tissue

and the total body fat.

And actually in that model 4 all the factors we could imagine are included there that could

confound the results and even in that situation, we had a significant correlation or association

between the liver fat and the pulse wave velocity and the liver fat and the intima-media thickness

of the carotid arteries.

Dr. Kessel: So are these models basically regression analyses or is it-

Dr. Lamb: No, mainly ANOVA linear analysis.

Dr. Kessel: Very good.

Now one thing I noticed is that you had a - at least it was termed - a high failure

rate in the acquisition of MR spectroscopy, which you used as the metric for hepatic fat,

and with approximately a third of the patients there wasn't usable data.

What do you think this was due to?

Not allocating sufficient time for the exam or some lack of training?

Dr. Lamb: That's an interesting question.

I think it's mainly due to the technical challenges you have to perform spectroscopy studies in

general.

In the liver it's one of the easiest variants of that.

In the heart, for example, it's much more complicated.

So we had a learning curve for the technicians.

That was one factor.

So in the beginning, they missed out a lot of scans because you have to perform it with

and without water suppression and sometimes we had two spectra with water suppression,

two spectra without water suppressions, so that was a problem in the beginning and it

was also a reason why we started developing newer techniques, so now in new studies we

prefer to use the imaging-based Dixon-like techniques where you have a very easy setup

and everybody can do the scan.

Dr. Kessel: I see.

Well, that certainly makes sense.

And you mentioned looking at the lipid-lowering drugs.

What was the effect of these when you kind of analyzed it in the regression models?

Dr. Lamb: Yeah, for the parameters we studied, that actually then - the difference between

model 1 and 2, there was an effect.

The significance of the model went down of the beta actually of the association, but

still it was statistically significant.

So there was an effect, but it did not explain the relation fully between the fatty liver

and the vessel stiffness and the IMT thickness.

Dr. Kessel: Okay.

So they sort of moved down the curve of the response curve if you will.

Dr. Lamb: Yeah.

Dr. Kessel: Okay.

And going forward, what do you think are the potential clinical and public health implications

of your findings other than everyone should control their weight?

Are there other implications?

Dr. Lamb: Yeah, there is one interesting pathophysiological finding that's a little bit more detailed,

but we found a difference between the IMT measurements association because there was

an effect of visceral fat.

Actually, when we included visceral fat in model 4, the relation between the liver fat

and IMT thickness was not significant anymore, but in the vessel stiffness, it didn't matter.

So the significance even got better.

So this may indicate that the pathophysiological process behind atherosclerosis is a little

bit different, different pathway, different factors than the vessel stiffening itself.

On the other hand, if you are very practical, we know from literature and we performed a

couple of those studies before, that there is still hope because if you do a diet, then

also the pulse wave velocity changes.

So it is still reversible if you are in a sort of sweet spot area.

Dr. Kessel: Well, thank you very much.

This is very exciting work and we look forward to seeing the results of your future manuscripts

and thank you so much for joining us today.

Dr. Lamb: Okay.

Thank you very much.

Dr. Kessel: You're welcome.

Bye bye.

Dr. Lamb: Bye bye.

For more infomation >> Hepatic Triglyceride Content Is Associated with Aortic Stiffness - Duration: 14:40.

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The Smothering - Steven Universe Fan episode - Duration: 13:48.

Careful Steven, don't bite down, you'll break the thermometer.

Ah, 98.6, good, nothing to worry about.

Uhh, Peridot. Do we really have to do this everyday? I mean, couldn't we, maybe, do the health check ups - Once a week?

No, this is fine. It's better to gather data as frequently as possible

Y'know Data's not going to stop me from getting sick again.

It's good to be prepared Steven.

Ok but, I just don't want you to waste too much time worrying about me.

*SNORT*

You can't waste time worrying

*WARP PAD ACTIVATES*

We're back

Hey Jasper, hey Lapis!

STEVEN! put that knife down, you'll cut yourself!

Hey guys...

Jasper: Hello Steven Lapis: Hey Steven!

Jasper: Did you sleep well?

Yeah I slept pretty great!

At least until Peridot woke me up again with her health check up

Health checkup? Are you sick?

You don't look sick

No, I'm not sick. Peridot's just been doing health check ups on me everyday since I caught that cold.

You're still doing that?

Yes I'm STILL doing that Jasper. Unlike SOME gems I actually care about Steven's safety.

We all care about Steven Peridot, you're just being overbearing

I AM NOT OVERBEARING!

I'm maternal

Steven, tell her

well you did take my second pillow away, cuz you said it might be...

...dangerous

I was worried about you being smothered in your sleep. Anyway you don't need two.

It was nicer with two though.

For someone so worried about smothering you seem to be doing a lot of it

Lapis: OOOOOoooooohhhhh

*Deep breath*

Jasper.

don't you perhaps have something

HEAVY, you need to be...

MOVING AROUND?

Steven. We're going out now to go on a mission, would you like to come with us?

I can go on the mission?!

Peridot: WHAT!?

*THUMP*

S-Steven can't go on mission! It's too dangerous, he's not ready, he doesn't have any of his powers, he can't-

Jasper: I ASKED! Steven...

Don't worry Steven, we'll be there to protect you.

Yeah Steven come with us, it'll be great!

You'll get to see us fight a giant monster up close!

Perdot: NO HE WON"T! He has to stay at a reasonable distance.

I wanna go on the mission!

Ah, Steven your first mission! You're gonna have so much fun!

Steven & Lapis: *Happy Laughter*

STEVEN WAIT!

You're still wearing your pajamas!

Okey Steven, let's wee here while Jesper and lapis scout ahead that way

We'll always be close to the war pad, and he's anything dangerous happens. Hey Steven come look at this. It's super gross, okay

What is this stuff we don't know it's some kind of slime residue made by the monster we were tracking

It's harmless to us, but it's killing all the plants around here plus. It's totally gross

Lapis don't get that muck away from him there could be

infectious

peridot

Lazuli lapis don't you dare?

Over here

Climb across

Mmm

Stay calm Steven use your arms to balance and walk slowly pearl if you need to

Careful Steven

Stephen when you're in the field

It's important to obtain as much knowledge of the area as possible so though you have the tactical advantage to crush your opponent's

Get on top of that vantage point tell me if you see anything important

What do you see

Well, I can see a lot of things I can see a big lake over that way

There's a bunch of rocks and what looks like more broken pillars up ahead

And then there's what kind of looks like a big clearing where surgeries are falling down

That was close you could have fallen and seriously damaged your cranium at least you were wearing your helmet

Hey, Steven want me to fly you around and look for the monster. Do I great we'll go right now

Peridot what are you? Don't worry peridot? I'll be fine. I'm with lapis whoa

I'm okay

She'll be fine. Oh

Hey, there's another river, and it's filled with gross slime stuff hey that must be where the monster is

Let's go get it whoa

Lapis shouldn't we wait for the others it'll be fine Steven come on it, but it's over here

Lapis I'm not so sure and it even come look lapis

Are you excited Steven if your very first official mission monster isn't it cool?

Yeah, it's pretty cool. Like I guess I just didn't think it would be so

funny

You want to see me beat it up

Okay, sure

Hey, you wanna bubble the gym I can bubble Jones probably try it out

Stephen you did it you bubbled your first gem we should go show Jasper repaired on ok

Hey guys look what Stephen did I bubbled a gym Stephen? You're helpful. Even you

Okay good mission everyone well done Stephen time to go home. Oh

Isn't this better Stephen nice and safe nothing dangerous

Capable of lately preferred in your bio matter you must be so relieved to be home

Well you've had a busy day Stephen time for bed, but it's not even lunchtime yet, Oh Stephen you and your

food

Okay, you can have lunch, but then you have to put on your pajamas and go to bed

Well

Steven

Home Easter Steven. I thought your heart had malfunctioned. Oh, and you spill your milk really Steven

You know better than a meat snacks in the dark

Peridot you don't have to apologize Steven. I'll clean this up, and you can just go back to bed

I'll tuck you in when I'm done

I'm not tired. What was that Steven? I said, I'm not tired are

You upset about your milk Steven, it's okay. We can go down and get you some more tomorrow. I'm not upset about the milk

I'm upset because you wouldn't let me do anything all day even though it was my first mission

and then you maybe go to bed at lunchtime and

It is tomorrow, which is why I'm not tired

Steven I be not so sure I like your tone young man

Stephen you've contaminated your plasma. Oh Stephen Stephen. Where are you going?

Stephen you can't activate the

Even even come back here, you're not even married shoes

Look even what are you doing?

Even please get down from there. It's dangerous keep it on yourself or better yet

Just be still and I'll get you down peridot

Peridot I'm really sorry I scared you. I know that you worry a lot when you think I'm in danger from rocks

Or we're getting sick or being on missions, and I know it's because you care

But you can't always be there to protect me from all that stuff. You need to let me do some things on my own

You okay, buddy

My head hurts

Well you did fall off of rock that

Stephen I

Realizing me a bit a bit

constraining with you lately, so I am going to be making an effort to allow you more freedom to

Learn on your own does this mean you're gonna stop doing health check-ups of course not even you just got concussed

Hmm, but after you get better we can change it to once a week like you wanted oh

Okay, hey can I have my second pillow back?

Cool

My head still hurts

For more infomation >> The Smothering - Steven Universe Fan episode - Duration: 13:48.

-------------------------------------------

Catch the mother of all news t...

For more infomation >> Catch the mother of all news t...

-------------------------------------------

Saab 9-5 2.0T SE **Eerste Eigenaar** Automaat** - Duration: 1:00.

For more infomation >> Saab 9-5 2.0T SE **Eerste Eigenaar** Automaat** - Duration: 1:00.

-------------------------------------------

Volkswagen Crafter €. 2.904,- voordeel. L3H3 3.5 T 2.0 TDI 140 pk (vsb 14937) Rijklaar! - Duration: 0:58.

For more infomation >> Volkswagen Crafter €. 2.904,- voordeel. L3H3 3.5 T 2.0 TDI 140 pk (vsb 14937) Rijklaar! - Duration: 0:58.

-------------------------------------------

Funny And Lucky Moments - Hearthstone - Ep. 294 - Duration: 5:43.

For more infomation >> Funny And Lucky Moments - Hearthstone - Ep. 294 - Duration: 5:43.

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Bungo Stray Dogs | Dangerous - Duration: 1:09.

Good evening.

Evil expects evil from others.

This is not for the eyes of children.

The bad guys' enemy.

For more infomation >> Bungo Stray Dogs | Dangerous - Duration: 1:09.

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Little Achievements (social anxiety/selective mutism) - Duration: 5:21.

(whispered) cat!

Um. Hey guys!

Um, very quick update video, um, with two-

- that's four-

two anxiety achievements

Well.

I tried to film another video about the first achievement last week, but

somehow in the middle of the video I just

stopped talking, I just... Suddenly, it locked-

(sighs) Well.

So, I'm just gonna report the achievement of last week and the one from today.

I'm not sure what's going on today?

Well, last saturday I was, um, at an optician

to finally get new glasses,

because I used to have glasses, but I haven't worn them in a few years,

I only wear them when I go to see a movie

because they're so uncomfortable...

But I actually need glasses...

I pushed it aside, I didn't want to do it because it would

involve so much talking,

explaining why I haven't done it earlier...

Well.

I went last saturday, that's an achievement in itself

that I finally, um, well- did it?!

And I did most of the talking on my own, I know, that

would be normal - should be normal for a twenty three year old,

...yes, I just had to think about how old I am.

But it isn't- It isn't normal, it isn't easy for someone, well, with social anxiety and selective mutism, okay?

(laughs nervously)

But I confidently talked to them,

even though I was very embarassed,

and I had to explain "Yeah, well, my eyesight is-

much worse than it used to be when I got these glasses that I have here,

yeah, I know I can't see with these glasses because, um,

the last time I got my eyes checked was six years ago and since then I haven't done shit because I was scared."

It was all very embarassing, but it was okay because

it was two nice old ladys,

and - yeah, sorry to say it, but it wasn't a man, and...

That makes it easier. For some reason it's easier to talk to old ladies instead of men any age.

(mumbled) I'm sorry.

(quietly) Yeah, it's not something I choose or can control, so...

Anyway! I did that - talked a lot, maybe even more than I had to...

Yeah, I-

I talked a lot when I was nervous, that's-

What?! Me?! (laughs)

I talk a lot when I'm nervous?!

I'm usually the kind of person that doesn't talk at all when I'm nervous, when I get anxious.

But I talked so much! Probably too much!

Which probably isn't good either, but hey!

It's an achievement, it's a success - for me.

(laughs) And well, today-

um, today is tuesday-

my family and I went to a restaurant

and...

I ordered my food! On my own! (nervous laugh)

and the waiter didn't have to ask

"Excuse me?"

which usually always happened when I ordered something.

(very quietly, almost inaudible) "Sorry, I would like..."

(normal voice) "Sorry?"

(still very quiet, a little louder than before) "I would like- this- and then that-"

(normal voice) "Excuse me..?"

(my normal voice from here) Or my parents would just order it for me to start with because

this shit would happen.

And today, really, I ordered my stuff, they didn't have to ask, they got me the first time,

(laughing)

And I even asked a question!

(laughs) I know!

Um, I asked a question about something in the menu,

and then I was too scared to ask another, more important question, but-

yeeeah. Okay.

It was still okay.

It wasn't that bad, it was just- the first question was what kind of tea they had,

what I could order,

and the second question would have been

what veget- vegetables are on this vegetarian pizza.

I should have probably asked that and not the tea question because I got a pizza with mushrooms.

Eh, it was still okay, there was still a lot on the pizza that I liked, that I could eat and,

the whole thing didn't taste like mushrooms when I took them and gave them to my mom.

(sighs) Yeeeah, okay. But I asked one question, I

couldn't bring myself to ask the other question, but

Hey, okay, it's... It's- It's a little success.

It's okay.

And...

obviously, I'm still alive. I didn't die, I didn't feel like I was dying (relieved laugh)

I felt like I was dying last saturday, and that's

unfortunately not being dramatic. It was that bad. I really couldn't breathe properly for

half an hour.

And this time it's okay.

I'm not dying. (laughs)

I did two things that I'm scared of and

I did well.

Somehow.

For more infomation >> Little Achievements (social anxiety/selective mutism) - Duration: 5:21.

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New Huge Jurassic World Surprise Egg For Kids / T-Rex Vs Indominus Rex / Raptor Unboxing - Duration: 1:12:24.

Wow okay it's great to see you again

we're gonna have another awesome giant

surprise toy opening today inside the

giant egg we have a lot of awesome

surprises but first of all guys let's go

ahead and take a look around us because

well I did was I like the drastic world

toys so much I went and bought almost

all of them again brand-new so I could

have them brand new in boxes on top of

all the other ones I have because guys

as of June this year they will not be

made anymore Hasbro has lost the license

so as of June this year you will not

find these on shelves anymore and the

prices will probably skyrocket so if you

do I know a Toys R Us still has a few of

them and some other stores have some ah

if it's something you're interested in

it in guys buy it soon Amazon still has

I'll put a link below this video where

you could get some of these on Amazon

they probably have the best prices there

so ah go ahead and check that out

but anyways don't wait guys because they

will be gone forever

okay let's see what is inside the giant

magical surprise egg Wow

okay are you guys ready wow this is

gonna be fun oh wow check this out it's

a whole container of 25 good dinosaur

characters Wow I have

I've seen good dinosaur toys in a while

guys this is gonna be awesome

let's go ahead and see what we have in

here although to tell you the truth I'm

not really sure if I'm gonna remember

all of the characters names so I might

need some help from you guys okay so

first of all we have our load and I

believe we have yep this is our laws dad

you could tell because the heads like oh

he's got like a square shaped head so

his head shape is different that Arlo's

okay so there is two of them and who is

neck okay here we have three members of

the t-rex family you've got butch you

got Vivienne and do you guys remember

what the third dinos name is if you do

drop me a comment I'm not going to tell

you I want to see if you guys remember

what it is okay and then we have four

thunderclaps if you remember thunderclap

was the pterodactyl that kept trying to

eat spot so he is a mood let's go ahead

move he's aside okay then we have four

book characters if you remember butch

was the velociraptor it was totally

clueless she's like good my name is

butch but remember what my name is

I forgot what yeah yeah yeah it's and

then strangely enough this one comes

with the cattle from the movie - oh

there was one more like the long horn

cattle and then we have three

Stegosaurus do you remember what her

name was

I'm thinking Alice but I could be wrong

God if you do know what it is let me

know in the comment section and then to

triceratop Vivien's or someone blue or

white and then three ankylosaurus is so

if you guys remember this one's name to

all it look cool and then the final one

is the Triceratops that has really fancy

horns and this guy is forrest woodbush

no no i'm wondering if he is a

triceratops he might not be because I'm

only seeing two horns there okay then

this next one is awesome

it was actually too big to fit into the

egg this is ash like set this is from ah

world of history dinosaurs this is set

for two to six three it includes a t-rex

on the hood so you got a t-rex

you got a skull a baby t-rex and an egg

also go ahead and open this up and check

it out does this look totally cool okay

so first of all you got the cute little

baby t-rex so this little guy looks

really cute and he feels soft I'm

surprised at how soft this guy feels and

then it comes with a little clear egg

that I guess he's supposed to hatch shut

up so this guy fits right into the egg

so you could have him hatching out of

the egg and then you have a cool

Triceratops skull check this thing out

you could actually open and close it

there and a bone like a chewed bone hear

that

the Triceratops is eating actually to

bone that the t-rex is eating

sorry not Triceratops and then the try

the t-rex wow this guy is awesome this

is one of the coolest like T Rex's I

have seen I am totally impressed check

this guy out and this guy is very

realistic feeling the texture and is

some type of like almost I think it's

plastic but it almost feels like it has

like a rubber membrane on the top so it

does feel very realistic you've got like

some type of a crown here on his head

spots on his neck really great paint job

on inside and out really good detail on

the tongue the teeth are incredible it's

like individual teeth and they are

painted so nice big claws on the hand

the legs and the bottom of this guy is

super good detailed check out the

striations and everything on this feet

beautiful paint job Wow seriously this

is one of the nicest dinos I've seen

come from Schleich and it is huge and SH

likes like makes a really nice set guys

I mean this guy is totally awesome wow

that was a cool set okay and last but

not least from the giant egg we are

going to pull this bag of 15 surprise

Jurassic world dinos I showed you one of

these bags before but this is a brand

new one you can see it's sealed here I'm

going to go ahead and open this for you

guys right now I bought several of these

bags because once again that's another

thing that's going to disappear off

forever

once the license runs out in June so

here they do come sealed in these little

triangle up like packages so I'm going

to go ahead and open them up so we could

check them out okay and then these do

come in this awesome

bag here says Jurassic world is open for

business visitors from around the world

can't wait to experience the thrill and

all of the actual dinosaur and guys ah

once Jurassic world two toys come start

coming out I will review all of them for

you I'm super excited because Mattel is

taking over so I think they're actually

going to do a much better job than a

Hasbro has okay so here is the

Triceratops this guy is awesome the

detail on these little ones is totally

cool and then that's a gray one then we

have a dark like a green and a really

light green Triceratops also

and each of these does have the little

JW logo there and then let's see what

else we have oh we have a red and yellow

t-rex you can see he's got the yellow

stripe on the bottom with tiny little

beady eyes some of these the paint job

is great some of them is not that great

but these are awesome sets did you get a

chance to buy these guys buy them Oh a

really cool Mosasaurus he's like tan

gold blue and black awesome and you know

I I do like the detail on these little

guys like I said the paint job is

questionable on some of some of them but

the detail is really cool here we've got

a gray and silver velociraptor like I

said they do all have the little JW logo

on it oh we have an endo - Rex this

guy's like a greenish brown color the

thing is each one of these packages is

guaranteed to have at least one

indominus rex so it looks like this one

does have just one some of them have

more than one and then we have couple

awesome spinosaurus this guy's like a

tan and gold color Spinosaurus is

probably one of my favorite dinos if I

have to pick three I would pick t-rex on

dominance rex and spinosaurus i do got

the big Spinosaurus toy from jurassic

world the animatronic one that one is

totally awesome and I'd done a lots of

videos with

and I also reviewed it if you want to

check out my Jurassic world or Jurassic

Park playlists okay so another same

Spinosaurus and then here we have

another one of the grey and silver

velociraptors so the detail is good on

these two I mean they have the third

claw and everything so that is cool then

we have a pterodactyl actually this

would be I believe a Pteranodon so here

it does also have the little JW this is

like a green it's a little bit of red on

the crown we have a die more food on so

this guy's cool it's like brown with

blue spots and some black colors on him

and what do we have here I believe this

one is an Allosaurus

[Music]

so that guy's cool he's like red and

black stripes and then we have a

pachycephalosaurus these guys like dark

green like a greenish almost like a

greenish tan color on top so that guy's

really cool there then we have aa

ankylosaurus this guy's like all one

color got like the spikes in the club

tail and everything and they do paint

kind of little beady black eyes on that

guy and then last of all we have a mega

soros this guy's like brown on the place

on his back of like gray then he's got

like the big spikes he uses to attack

with so there we have it guys ah those

were the dinos that we had today so we

had an awesome surprise egg if you guys

did enjoy the video please go ahead and

click like and the thumbs up you guys

are a great audience guys I really

appreciate you guys watching over the

years and if you guys if there's any new

viewers are viewing I do got a lot of

dinosaur videos dinosaur battles guys go

to the Jurassic world playlist at the

end of the video there's a lot of fun

videos over there and if you do want to

buy any of the drastic world toys like I

said I'll put a link below the video

ah to where you could buy them on Amazon

I am affiliated with Amazon which means

I get a small sales commission but it

costs you the exact same amount as if

you just went on Amazon so if you use my

link you'll be getting some awesome toys

and also helping to support my channel

and let me know which one of these are

unopened toys you see here is your favor

I think mine is the original indominus

rex that is one you already are not

going to find anymore

I mean that one I think I paid

seventy-five dollars on eBay to get that

guy new again so it's sad but that one's

going to be hard to find but a lot of

these other ones you could still find so

you have until June so time is Rudy Gow

thanks guys and I will see you guys soon

Wow guys that was a lot of fun and if

you enjoyed the video make sure you

click Subscribe and the thumbs up button

down below the video and today secret

word is the word go ahead and put that

in the comment section down below the

video on those you remember my club go

to the video ends there's and also then

curves off more fun with you click the

boxes below for a lot more fun videos

and if you want to see even more go

ahead and click the subscribe button

For more infomation >> New Huge Jurassic World Surprise Egg For Kids / T-Rex Vs Indominus Rex / Raptor Unboxing - Duration: 1:12:24.

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South Indian Actress - 25 South Actresses | Age | Height | Weight | Body Measurement * Part 2 * - Duration: 3:56.

Please Check Video Description For Details

For more infomation >> South Indian Actress - 25 South Actresses | Age | Height | Weight | Body Measurement * Part 2 * - Duration: 3:56.

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North Korea news: Japan insists it WON'T shoot down Kim Jong-un's missiles - Duration: 2:53.

North Korea news: Japan insists it WON'T shoot down Kim Jong-un's missiles

has fired two rockets over Japan in recent months. One of the rockets was an. Japan did not attempt to shoot down the missiles on either occasion despite the flyover sparking sparking loudspeaker alerts and TV warnings telling citizens to take cover.

Minister of defence Itsunori Onodera today said that there was no need for action as the rockets didn't pose a threat to Japan.

He said: "The recent missile tests by North Korea passed at high altitude and there was no fear of them falling in our territory or territorial waters so we did not shoot them down.

"Whether it is Japan or any other country, I think that shooting down a ballistic missile could be construed as a military action.

"Unless you judge it is an attack on your own country, I think it is difficult to shoot down such missiles.".

Mr Onodera has ruled out shooting down missiles in the future – giving Pyongyang the go ahead for further tests, sparking fears for World War 3 amid escalating tensions between the rogue state and America.

Just last month Japans Chief Cabinet Secretary Yoshihide Suga said the nation will not tolerate the repeated and excessive provocations". Earlier today if it doesn't back down on sanctions against the communist state.

The North Korean leader issued the rounds of threats while blasting , calling him a "headless chicken" and "suicidal". to "goods, funds people and technology if it continued to test nuclear weapons.

This sparked fury from Kim, who retaliated by saying: "Japans such rackets inciting the tension of the Korean peninsula is a suicidal deed that will bring nuclear clouds to the Japanese archipelago.

"No one knows when the touch-and-go situation will lead to a nuclear war, but if so, the Japanese archipelago will be engulfed in flames in a moment. This is too self-evident." .

For more infomation >> North Korea news: Japan insists it WON'T shoot down Kim Jong-un's missiles - Duration: 2:53.

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Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.

HELLO GUYS, A LOT OF PEOPLE ASK ME

ABOUT HAPPINESS AT WORK,

"OH I'M NOT HAPPY DOING

WHAT I'M DOING, MY JOB,

I'M NOT HAPPY". SO I STOP TO THINK

IF THIS PERSON KNOW WHY SHE'S DOING THAT OR

WHAT THE PROPOSE OF HER WORK

WHAT WOULD YOU DO

IF YOU COULD DO SOMETHING FOR FREE ?

AND IT MAKES YOU GLAD,

.....GIVE YOU A BIG PLEASURE....

I THINK THIS IS THE BIG SEARCH

WHEN YOU DO SOMETHING YOU LOVE,

AND SOMETHING THAT THE WORLD NEEDS,

THIS IS YOUR " MISSION "

WHEN YOU REALLY DO SOMETHING THAT THE WORLD NEED,

AND THE WORLD IS ABLE TO PAY YOU FOR THIS

IT'S WHAT I CALLED "VOCATION "

YOU REALIZED WHAT THE WORLD ABLE

TO PAY YOU...

...FOR THIS, AND REALLY MAKE....

...THIS HAPPENED

YOU TURN THIS INTO YOUR " JOB "

AND WHEN YOU ARE DOING

WHAT YOU LOVE, IT'S YOUR "PASSION "

WHEN YOU DISCOVERED YOU " PASSION, MISSION,

....JOB AND VOCATION "

AND FIT IN INTO YOUR LIFE,

YOU REALIZED WHAT IS YOU " GIFT "

THAT IN PORTUGUESE IS " DOM "

WHEN YOU DISCOVERED YOUR GIFT,

YOU ARE FINALLY ABLE TO WORK THE REST

OF YOUR LIFE INTO SOMENTHING YOU...

......LOVE

AND I ENSURE THAT YOU WILL BE...

VERY HAPPY

........

GO TO MY WEBSITE,

THERE'S EVERYTHING THAT I TOLD YOU HERE

AND SUBSCRIBE BECAUSE

REALLY NICE THINGS WILL COME FOR WE THINK TOGETHER

THANKS

For more infomation >> Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.

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How to Send WhatsApp Voice Messages Using Google Assistant - Duration: 2:02.

How to send whatsapp voice messages using Google assistant to get started

touch and hold the home button on your Android phone or from the google app

itself and simple say okay Google send message to Mike from whatsapp chat with

Mike sure what's the message hey Mike I need to talk to you call me as soon as

possible got it do you want to send it or change it send it it's on its way

okay Google send message to Mike from whatsapp chat with Mike sure what's the

message cancel it okay no problem okay Google send message

to Mike okay message to Mike do you want to use SMS or whatsapp whatsapp message

to Mike using whatsapp sure what's the message name's Walter Hartwell white I

live at 308 negra arroyo lane albuquerque new mexico got it do you

want to send it or change it cancel it

okay no problem get more info from Google assistant to web find all you

need to get started with Google assistant thanks for watching and stay

tuned for next videos Cheers

For more infomation >> How to Send WhatsApp Voice Messages Using Google Assistant - Duration: 2:02.

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Fibromyalgia - causes, symptoms, diagnosis, treatment, pathology - Duration: 7:29.

The term fibromyalgia can be broken down.

Fibro- refers to fibrous tissue, -my- refers to muscle and -algia refers to pain.

Fibromyalgia is a chronic condition, which occurs more often in women, that causes widespread

muscle pain, extreme tenderness in various parts of the body, and sleep disturbances.

Normally, if a person cuts their finger, a specific type of sensory neuron called a nociceptor

or pain receptor, converts that stimulus into an electrical signal.

These are the first neurons and they're primarily found in the skin, joints, or the

walls of organs.

The electrical signal goes from the dendrite of the nociceptor into its peripheral axon

branch and heads up the hand and arm towards its cell body.

The cell body is located in the dorsal root ganglion which is a cluster of nerve cell

bodies located in a dorsal root of the spinal nerve.

The dorsal root ganglia contains the cell bodies of many sensory neurons that receive

information.

So in this case, the cell body would receive the electrical signal, and if it's strong

enough, it would start to release substance P, which is a small chemical involved in pain

perception.

Substance P would go down the other axon branch of the nociceptor and would get released from

the neuron's terminal button.

Substance P then binds to receptors on a second neuron which has its cell body located in

the dorsal horn of the spinal cord, which makes up the back portion of the spinal cord

that receives sensory information.

There is also a separate group of neurons called inhibitory neurons in the spinal cord

that dampen or reduce the pain response, counteracting the effect of nociceptors.

These inhibitory neurons release neurotransmitters such as serotonin and norepinephrine and they

also act on the second neuron in the spinal cord to inhibit the pain signal.

If the signal from the nociceptors is greater than the signal from the inhibitory neurons,

then it triggers the second neuron in the spinal cord to fire an action potential.

This electrical signal goes all the way up the spinal cord to the brain where the pain

is perceived.

So while, the pain signal races towards the brain, important events are happening in the

damaged finger as well.

Epithelial cells near the damaged area start to release nerve growth factor.

That nerve growth attracts nearby mast cells which start to release even more nerve growth

factor - amplifying the effect.

The high levels of nerve growth factor do a few important things to nociceptors.

It boosts the growth, makes them more sensitive to pain, and makes them produce even more

substance P.

In fibromyalgia, the underlying mechanism isn't well understood, but there seems to

be a problem with how the brain receives pain signals.

Generally speaking, individuals have low levels of serotonin, which is involved in inhibiting

pain signals, and elevated levels of substance P, and nerve growth factor, which are involved

in propagating pain signals.

Together, these are thought to play a role in the hypersensitivity to pain, which hints

that fibromyalgia might be a condition of central sensitization.

In other words, if a person with fibromyalgia were to cut their finger, they would perceive

more pain compared to other people.

In addition, central sensitization means that a person might have a wide range of sensitivities

- affecting everything from how they sleep to how they feel to how they think.

If the person with fibromyalgia has negative emotions like depression, anxiety, and psychological

factors like negative beliefs and attributions it can also amplify this sensitivity to pain.

Fibromyalgia often runs in families so there seems to be a strong genetic link too.

And environmental factors like child abuse are also linked to fibromyalgia.

Diagnosis of fibromyalgia is generally based on a few factors.

First, there's pain in at least seven or more areas of the body, with a symptoms severity

scale score of at least five points out of a possible twelve.

The symptoms severity scale gives points for a wide range of symptoms - everything from

difficulty concentrating and remembering things - sometimes called "fibro fog" to fatigue

to poor sleep and waking up unrefreshed and having a headache.

Alternatively, there might be pain in at least five or more areas of the body, with a symptoms

severity score of at least nine points out of a possible twelve.

Additionally, the symptoms have to be present for at least three months, of course, the

pain cannot be due to another disorder.

Treatment of fibromyalgia requires a holistic approach.

Regular exercise like cardiovascular fitness training which includes fast walking, biking,

swimming, or water aerobics can help by reducing pain and fatigue.

Relaxation techniques and good sleep hygiene can also help.

If these approaches don't work, medications can be used.

For example, amitriptyline, and serotonin-norepinephrine reuptake inhibitors, or SNRIs, can help by

elevating serotonin and norepinephrine levels.

Finally, anticonvulsants like pregabalin and gabapentin which slow nerve impulses can help

with sleep problems.

All right, as a quick recap, fibromyalgia is a long-lasting condition that causes widespread

muscle pain, excessive tenderness in many areas of the body, and sleep disturbances.

And people with fibromyalgia have a lower threshold to pain.

The diagnosis is often made with a clinical history which shows over three months of widespread

pain that cannot be due to another disorder.

Treatment of fibromyalgia involves in easing symptoms to improve the quality of life.

In some people, regular exercise and sleep may reduce pain and fatigue.

In other people, antidepressants, like SNRIs reduce symptoms.

For more infomation >> Fibromyalgia - causes, symptoms, diagnosis, treatment, pathology - Duration: 7:29.

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BlingGuard Dots Stabilizing Earring Supports - Duration: 3:35.

For more infomation >> BlingGuard Dots Stabilizing Earring Supports - Duration: 3:35.

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FABFILTER PRO Q 2 TUTORIAL (SUBTRACTIVE EQ) - Duration: 15:06.

hi guys welcome to another tutorial today I'll be talking about subtractive

EQ with fabfilter pro-q to fabfilter pro-q 2 is a high-quality equalizer

plug-in with unrivaled sound and interface available in VST VST 3au axr

tas and audio suit formats

if you don't use fabfilter pro-q you should it's a really good EQ Scott music

function sounds pretty great for digital thank you alright so open up your

project in Ableton or whatever the AWU are in

are you sable certain reason let's talk about what subtractive EQ is

there are two types of Equalization there's additive EQ and subtractive EQ

subtractive EQ it's the process of removing frequencies in order to make

room for other frequencies on another instrument additive EQ is turning up

frequencies in an instrument usually to help fill out the frequency range in the

instrument and hopefully in this song the reason you want to do subtractive EQ

is to clean up your tracks obviously so I'm going to show you guys how to do

that this probably won't be as accurate as I normally to buy e queuing

so there's a lot of things we could EQ there the most obvious thing to do would

be to roll off the highs and 808 nothing too crazy so for that I mean we could

really just use a stock Ableton for that but I'll show you guys how to do in fat

filter since this is going to be a fabfilter tutorial it's a dragon

fabfilter if you want to trigger a high shelf you double click over here

over here and on we'll create a high shelf you double-click in the middle it

will create a bell

and meet locals for now from there I played with the gain and the frequency

until I found something I liked and after that you can play with the

percentage here to change how much you want it to be affecting the track

okay name that I cut

now we're gonna do the offset here to the sample let's just meet the drums -

for now so we're gonna do the same thing as we did on the other side click on

this second line here and it will create a low shelf

and basically from there you can just drag this point around until you find

somewhere you like and if you have a middle mouse scroll you can use that to

change the cue

I would say around there it's pretty good

and labeled my track there cut low for bass I'm going to bring in the kick now

just a kick kick sample and base

velocity not sure if I have to do any subtractive EQ to clean out the room for

the kicks cut through the sample because it seems to be cutting through alright I

think I may want to move some highs from that kick nothing too drastic just so

sound shape it a little bit so I'm gonna do the same thing I did earlier create a

high shelf then drag it around I find that sweet spot

I should decide to create a second shelf here to see if I could shape it a little

more

I'm gonna change the percentage a little bit to try fitted in mix

it's perfect right there

quite often you'll have to cut room on your sample or since for your kick I'll

show you guys what that would look like well I do not think it's really

necessary here I'll show you guys anyways

it might look something like that

or like this

or even some crazy shit like this

okay back to what we're actually working on though

now it's time to bring in the hi-hat it definitely cut some lows on that

so I decided to do a little shelf and we're bringing some way to fuck up

because I think it's mostly high frequencies but it could use some

shaping it does sound a little low

sounds pretty good right there this is a very drastic setting by the way I would

I would almost out like more more often tonight probably way more down here for

most high hats this one is very strange so you know don't copy me exactly it

just go by here but these are all like guidelines kind of some basic guidelines

formulas whatnot techniques okay now we're gonna do some to the snare I mean

it sounds pretty good

when you're doing any sort of mixing or subtractive EQ it could really help to

turn to up the volume or turn down the volume overall just to get an ear for

how different it could send a sample still has a lot of loads kind of fucked

so I'm going to undo some more subtractive EQ to that

yes not enough we're gonna have to call him for the big guns

no more shelves here we have to go for a fucking a goddamn filter

ok so double-click over here again create a little shelf and then we're

going to turn it into a low-cut and then you can change the queue or the

shape of it here with their middle scroll

and adjust that until cut out any unwanted base you can also change the

amount it's cutting here or any of these I believe there's some very extreme

settings here look at this 96 decibels per octave jesus fucking christ

definitely allow this background noise of that sample

spring the base back in may want to cut some room for the hi-hat in the sample

also so let me do that now

so usually the hi-hats will be anywhere from like two K to ten plus K

the sounds so you're usually gonna want to try to figure out where you're gonna

want to cut you can either do some sort of additive technique try to find it

there's definitely something at 6k here

some gonna do some subtraction here

basically I move it around so I can hear the hi-hat coming through a little

clearer because if you have it a little too high it sounds a little too sharp

and you have it a little too low it sounds a little too flat so usually I

try to bounce it around so I find a nice little happy medium just setting a

little bit you can also cut a room for other instruments as well I feel like

these are all I need to really do for this though

alright guys how's my tutorial on how to do subtractive EQ with fabfilter pro-q -

hope you guys enjoyed that thank you for watching don't forget to comment like

subscribe if you guys have a checked out on music make sure you go check that out

I'll see you guys next time peace

For more infomation >> FABFILTER PRO Q 2 TUTORIAL (SUBTRACTIVE EQ) - Duration: 15:06.

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This is the Part Where He Kills You - Defeating Wheatley and going to the Moon in Portal 2 END - Duration: 2:11:34.

For more infomation >> This is the Part Where He Kills You - Defeating Wheatley and going to the Moon in Portal 2 END - Duration: 2:11:34.

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Enterprise Concert Confessional with Fitz and The Tantrums - Duration: 1:48.

What up everybody, it's Fitz from Fitz and The Tantrums.

Hey everybody, this is Noel of Fitz and The Tantrums.

And this is our Concert Confession.

We are going to surprise some of our fans. They don't know that we're here

and hopefully they don't, I don't know punch me or something.

Every single time I'm in the car I always have some kind of music playing.

We have all Fitz and The Tantrums' music downloaded on our Spotify.

Inspiration that I find when driving is normally

because I have the opportunity to listen to as much music as possible.

Sort of fed into the way we make our music.

Just me in the car, singing as loud as I can 'cause no one's around.

One of the most personal songs has to be "The Walker."

Whenever I was feeling down or you know, things were happening in life, I would just listen to that one.

Because it's sort of an anthem for the inner freak in all of us.

"Hand Clap" is definitely my favorite song by them.

"Hand Clap."

I love Fitz and The Tantrums because the vibe they put on when they perform is just so energetic.

They're catchy and if I introduce them to someone,

it's getting someone else into that music.

They kind of give you the energy to go through your day.

Their music - it's so different than what's out now.

If I could meet Fitz and The Tantrums, I would say...

Thanks for making this memory for me. This is my kid's first concert.

It'd really make me happy.

You're making a big, huge memory for my family.

Oh my God.

Oh! Oh my God!

Hi! Oh my goodness!

Hi! Oh my God.

Don't cry!

This is incredible.

Let's hug it out!

We wouldn't be in the place that we are

living out our dreams without the support of those fans.

Thanks Enterprise for bringing us closer to fans, and we'll see you out on the road.

For more infomation >> Enterprise Concert Confessional with Fitz and The Tantrums - Duration: 1:48.

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10 Deaths Caused by Video Games - Duration: 6:00.

10 Deaths Caused by Video Games

Playing video games is such a universal college practice that schools might as well issue

minors in gameplay.

And for most people, gaming is a great way to unwind, kill time, or hang out with friends.

Yet for some — the few, the proud, the mentally unbalanced — video games are the spark held

to the powder keg that sets them off.

Not every death tied by the media to video games is actually related to them, but the

ones on this list make for gruesome exceptions.

It's worth reiterating that most gamers are the rational sort, and those who are pushed

over the edge by games are usually already falling and just looking for an excuse to

lose control.

1.

Alayiah Turman:

Tyrone Spellman is one of the worst people you'll ever read about.

A man in love with his Xbox, Spellman went apopleptic when his 17-month-old daughter,

Alayiah, accidentally pulled the cords out of the wall.

Rather than ensure the child's safety or just fix things and move on, Spellman cracked

her skull repeatedly, killing her.

He got up to 47 years in prison for the crime.

2.

Shawn Woolley:

Online RPGs are known for their addictive qualities — players get so obsessed that

they devote all their time to the game, often at the expense of a social life — but rarely

have they had an effect like they did on Shawn Woolley.

He killed himself in the fall of 2001, and his mother attributes the death to a lack

of reality and socialization encouraged by Everquest.

3.

Ace Mealer, James Crump, Arnold Strickland:

In June 2003, a teenager named Devin Moore, who was a big fan of the Grand Theft Auto

series, went on a killing spree.

He'd been brought to a police station on suspicion of stealing a car, at which point

he grabbed a gun, shot two officers and a 911 dispatcher, and grabbed a set of car keys

as he made a speedy exit.

He drove off in a police cruiser but was quickly captured.

When caught, he reportedly said, Life is like a video game.

Everybody's got to die sometime."

Classy guy.

4.

Aaron Hamel:

Chalk up another one for Grand Theft Auto (it's understandable why so many critics

complain of the game's cop-killing stories): Aaron Hamel was killed and Kimberly Bede was

injured when two stepbrothers in Tennessee, aged 14 and 16, opened fire with rifles they'd

found in their home.

The boys cited Grand Theft Auto III as the inspiration for their real-life destruction.

5.

Zhu Caoyuan:

In 2004, Shanghai gamer Zhu Caoyuan was murdered by fellow player Qiu Chengwei in a dispute

over a "cyber-weapon."

Qiu won the weapon in the online game Legend of Mir III and loaned it to Zhu to use in

the game, after which Zhu turned around and sold it.

Jerk move, to be sure, but when cops told Qiu they couldn't help him because the stolen

property wasn't real, Qiu confronted Zhu and stabbed him in the chest, killing him.

Qiu earned a death sentence with the possibility of having it commuted to life if he behaved.

6.

An unnamed Russian man:

Lineage II is a pretty typical MMORPG, which means it's capable of inspiring pointless

feuds that bleed over into real life.

Case in point: when a pair of Russian guilds got into an online shouting match over the

killing of one of their characters, the players opted to settle the score on their own.

They met for a fight that got so bloody one man died of his injuries on the way to the

hospital.

7.

Dylan Lee Edmondson:

Dylan Lee Edmondson was 3 years old when he died in October 2010.

His mother, Alexandra Tobias, was a FarmVille junkie who was engrossed in the popular Facebook

game when her son started crying.

She shook him several times, likely hitting his head, causing his death.

She could get 25 years in prison.

8.

Xiao Yi:

Another disheartening suicide: Xiao Yi was 13 when he jumepd from the roof of a 24-story

building.

According to notes he left, the boy was entranced by the world of Warcraft III and hoped to

reunite with his online friends in the afterlife.

9.

Mai Thi Mau:

Dinh The Dan, 13, strangled and killed Mai Thi Mau, 81, in order to get money for video

games.

He used a piece of rope to choke her before robbing her and burying her in a pile of sand

at his house.

He wanted the money to pay for his online video game habit, so he decided to rob and

kill someone to get it.

The boy was sent to a "reeducation camp" in hopes of changing his behavior.

10.

An unnamed Chinese man:

Even by the standards of this list, this is a creepy, sad entry.

In 2007, a Chinese man played online video games for three days straight in an Internet

cafe.

That's 72 hours of consecutive gaming.

Even assuming breaks for food and relief, that can only end badly, and it did: after

three days, the man dropped dead from exhaustion.

Why did he do it?

What was he playing?

Did he have nowhere else to go?

Horrible questions with no answers.

For more infomation >> 10 Deaths Caused by Video Games - Duration: 6:00.

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Mitten in São Paulo Polizei verhindert den "größten Bankraub der Welt" - Duration: 1:57.

For more infomation >> Mitten in São Paulo Polizei verhindert den "größten Bankraub der Welt" - Duration: 1:57.

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10 Things You Won't Believe You Can Major In p2 - Duration: 5:25.

10 Things You Won't Believe You Can Major In p2

Culinary school isn't too weird a concept. You go there and you learn all the different ways to cook and then maybe get a low paying, high stress job in a restaurant.

But the advantage of it is that you learn all sorts of different ways to cook. At Kansas State, though, you can decide to instead focus on one of the most common ways to make food taste better: baking.

You can concentrate on either production management or cereal chemistry. Ok, we guess this is different from just a cooking degree and you might get a job in the food production industry.

But still, just… come on. Cereal chemistry? Who bakes their cereal? We know that's not what it means, but that's what it sounds like.

And what it sounds like is ridiculous. Do we really need some pinhead professor to tell us how to pour our Frosted Flakes?.

That's right, that was not a joke. This is an actual major at an actual college that you can actually major in.

If you thought the coolest people in The Big Lebowski were the people working at the alley, this major might be for you.

Most people in business get more general degrees than this, but if you know what you want maybe you should get really specific – like a degree in Bowling Industry Management.

The only college with this option is Vincennes University in Indiana. And if you get bored, take advantage of their onsite 18-lane bowling alley.

That's right: if you need to relax after class, head on over and knock down some pins. On second thought, this doesn't sound that bad. Winemaking.

People, as a general rule, like alcohol. Most adults drink at least once in awhile.

So, there's probably going to continue to be jobs for the people who make it. But is going to college really necessary to make wine? Well, some colleges think so.

In order to fancy it up even further, colleges actually call these programs Enology, which means the study of wine. Oh, it sounds so sophisticated.

Well, at least it will allow you to gain an intensive knowledge of what goes into making wine at the age of 18 or so. We're sure that you won't abuse that knowledge.

It's fascinating and useful to study other cultures. One of the most interesting things to study about other cultures is their mythology.

You can learn a lot about a society by studying their folklore. Yep, that's a great thing to read about in your spare time. But surely it isn't a full on major anywhere… right? Wait… it is?.

Ok, well it's probably some small school you've never heard of. Well, yes, if you've never heard of Harvard University.

That's right, the college everyone thinks of when they think 'prestigious' has a major in Folklore and Mythology. We suppose you can probably still get a good job with it, as long as you emphasize where you got the major.

"You majored in what? Oh, I don't think… oh, from Harvard. Oh yes, of course, can you start Monday?" We're assuming that's how it works, anyway. Whatever you want (Student-designed major).

Turns out, some colleges realize students might have interests that don't fit neatly within one college major. So, they give them the option to double major.

Or even maybe triple major. Or, if that doesn't work, some of them just let kids make up their own major.

At several universities, there exists what is called a student-designed major. The student decides what to call it and they get it put on their diploma if they do what the college tells them to, and they get through all their classes.

Of course, the college has to approve their choice, so it's not really whatever you want. But you can probably convince them of a lot of different things.

Maybe we should send some of our writers to school for listicle studies? That certainly would have been more helpful than our Bowling Management degree. Just to remind you, that's a real degree.

If you take just one thing from this article, let it be that. There are people getting a degree to prepare them for a career in the bowling industry. Come on!.

For more infomation >> 10 Things You Won't Believe You Can Major In p2 - Duration: 5:25.

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Breaking: Scalise Issues Game-Changing Statement on Gun Control | Top Stories Today - Duration: 3:02.

Louisiana Republican and House Majority Whip Steve Scalise recently returned to Congress

with much fanfare after recovering from the nearly life-ending bullet to the hip he took

from a deranged liberal gunman at a GOP baseball practice in June.

Scalise sat down for an interview with Fox News host Martha MacCallum, and with the horrific

Las Vegas massacre having just occurred, was asked for his thoughts on the Second Amendment

and whether his position had changed in light of the Vegas incident and his own personal

experience, according to the New York Post.

"I think it's fortified it," the congressman said of his support for gun rights.

"Because first of all you've got to recognize that when there's a tragedy like this, the

first thing we should be thinking about is praying for the people who were injured and

doing whatever we can to help them, to help law enforcement."

"We shouldn't first be thinking of promoting our political agenda," he added, according

to the Washington Free Beacon.

"And I think we see too much of that where people say 'OK, now you have to have gun

control.'"

"First of all, look at some of those bills — those bills wouldn't have done anything

to stop this," he continued.

"That gunman actually cleared background checks so to promote some kind of gun control

is the wrong way to approach this."

Scalise proceeded to point out that it was Capitol Hill police officers with guns who

saved his life and other congressmen on that ball-field, and noted that countless gun-carrying

Americans similarly save the lives of themselves and others everyday.

"Regular citizens that just have a passionate belief in the Second Amendment that have their

own guns use guns every single day to protect themselves against criminals," he stated.

"And those stories never get told or hardly ever get told.

"But that's a different side of the story that I think is important," he added.

"People use guns way more to defend themselves from criminals than criminals using guns to

hurt people."

You can watch the entire segment below.

The portion specifically about gun control begins after the 5:00 mark:

Scalise nearly died when he was attacked out in the open by a rifle-wielding madman, and

some likely suspected that his brush with death may have had an effect on his stance

regarding gun rights.

However, rather than shift toward wanting more government controls over the rights of

the citizenry, Scalise made it clear that he "absolutely" still defends the Second

Amendment and that his stance in that regard has actually been "fortified" by his harrowing

experience.

As a final note, Scalise holds an "A+" rating from the National Rifle Association

and has lent his support to numerous pro-gun pieces of legislation, including the national

right-to-carry or nationwide reciprocity for licensed concealed carriers.

What do you think of what Scalise had to say about gun control?

Please share this news if you're glad Steve Scalise has recovered and is still standing

up for the Second Amendment.

Scroll down to comment below and don't forget to subscribe top stories today.

For more infomation >> Breaking: Scalise Issues Game-Changing Statement on Gun Control | Top Stories Today - Duration: 3:02.

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10 Things You Probably Didn't Know About Richard Nixon - Duration: 14:29.

10 Things You Probably Didn't Know About Richard Nixon

Nixon was a Quaker. For those of us who don't know, Quakers draw their roots from the Christian religion and first began in England in the 1650s.

The official name of the movement is the Religious Society of Friends, and there are currently around 210,000 Quakers around the world.

They strongly believe in peace, equality, social justice, freedom of choice, and in a strongly knit yet diverse community life. Quakers also seek to live a simple life so as to not put a great burden on the world.

They believe that God is love and every person can have a strong relationship with God without the need of a religious figure, like a priest or minister.

They don't regard any book as being the actual word of God, seeing the Bible as a great inspirational book, but at the same time, seeing others in the same way.

Now, even though they trace their roots back to Christianity, and outsiders see them as a branch of it, most Quakers actually see themselves as part of a universal religion that has many Christian elements to it.

Hannah Milhous Nixon, Richard Nixon's mother, was a devout Quaker who exerted a strong influence on her husband and children. When Nixon was 9-years-old, the family moved to the Quaker community of Whittier in California.

As a young boy, he attended church every Sunday, played the piano during the church services, attended chapel hours every day, and enrolled at Whittier College – which was a Quaker institution. Growing up, Nixon lived a modest life.

He recalled his childhood by saying, "We were poor, but the glory of it was we didn't know it." But after his mother's death in 1967, he never again attended any other church services.

In his memoirs, Nixon talks about his religion and its influence on him in only three paragraphs of the book.

These, together with some of the ways he acted as President of the United States, have led some to believe that he only used his pacifist religion to advance his political career and gather support for his bid at the presidency.

Nixon, College, Fraternities, Hazing, and Initiation Rituals.

Richard Nixon would have been considered a nerd by any modern standards. He was extremely diligent and studious.

And because of these traits, he was offered scholarships to both Harvard and Yale. But because of the Great Depression, and his older brother's tuberculosis flaring up, he wasn't able to attend either due to financial difficulties.

Instead, he went to local Whittier College. And even though he had a rather withdrawn personality, Nixon joined or took part in almost every club or event in sight.

Besides his usual classes and his time spent at his father's store, Richard was also part of the college's football team, dramatic society, the debating team, the college orchestra, student politics, the Glee Club, and attended events like basketball games, off-campus picnics, opera shows, and weekend skiing trips, among others.

As a Quaker college, Whittier forbade fraternities, seeing them as a sort of class distinction tool. But the better-off students found a loophole here and founded a men's student society known as the Franklins instead.

Its main purpose, of course, was to act as a fraternity in all but name, and show off their social elitism at every occasion.

Among Nixon's first actions as part of Whittier was to start an anti-establishment and anti-Franklins society known as the Orthogonians. Most of this society's activities revolved around being as different as possible from the Franklins.

When the "snobs" dressed in tuxedos to pose for group photographs, the Orthogonians would wear open-neck shirts. All of the society's founding members, Nixon included, were football players.

One of the only things Nixon particularly hated about college life was the hazing rituals as part of initiation to different societies and clubs.

One such Orthogonian joining ritual involved going into the woods near Whittier, digging up the corpse of a wild boar (the society's mascot), and eating some of its raw meat there on the spot.

But since wild boar corpses weren't so easily available in California, they exchanged it for a dead dog.

Since Nixon was a charter member, he never actually had to do it himself, but he had to be present whenever someone else did. One hazing ritual he did have to be involved in was when he joined the Glee Club.

He had to strip naked and then sit on a cake of ice. And every time he sat up, they would take a big paddle and smack him on the butt so it would warm up.

After he went through this hazing ritual, he got pneumonia. His father was outraged and intent on suing the other students, but Richard stopped him.

Overall, though, he said he had a great time in college. After Whittier, we went to Duke University School of Law. His First "Major" Political Victory.

Throughout his college years, Richard Nixon had a visible interest in politics.

He became president of his freshman class, then in his second year he became a sophomore representative on the student executive committee, and then vice president of the student body in his third year.

He won that election by a landslide victory with 267 votes to 73.

One of his fellow students later recalled something that Nixon said on a bus ride as part of the Glee Club trip: "You should never run for office from a city council base.

If you're going to go for politics, don't hang about with local politics, go for the big time." Of course, at the time, none of them had any idea of the foreshadowing they were presented with.

In any case, at the beginning of his fourth year in college, he placed his bid for the student body presidency, going against a student from the Franklins.

But while his opponent focused his campaign on a new student union building, old Dick Nixon focused on dancing.

Even though he was overall shy and an awkward dancer, he knew that the victory wouldn't come from the two opposing societies themselves, but rather from off-campus voters and the girl's dormitories.

So, by focusing his campaign on the overwhelmingly popular issue of ballroom dances, not only was he able to win the election, but even swing some of the Franklins to his side.

After a crushing defeat, his opponent said that, "His [Nixon's] issue had student appeal and I guess mine was a little too practical. It was the silver-tongued orator against a babbling idiot. Even if he didn't say anything it sounded good.".

Now, winning an election was one thing, but delivering on the promise was totally another. As a Quaker institution, Whittier forbade all ballroom dances, and because of that, Nixon's first proposal was immediately rejected by the college president.

But he then made an appeal to the trustees saying that it would actually be better and safer for the student's moral well-being to have dances on college campus under proper supervision, rather than going off to LA to dance at those Prohibition era-style speakeasy establishments there – something that they were already doing, by the way.

Amazed by his audacity of going over the college president's head, one trustee said: "Think of the nerve of this lad, appearing before the august body of the Board of Trustees at Whittier College in a plea for no dancing on the campus which the Quakers didn't look fondly upon at all.

It took a lot of guts and nerve and crust, I think, to do that. But he did it and convinced the board that they really ought to modify their policy.".

And to smooth the transition over, Nixon came up with a face-saving compromise.

Instead of asking for the board's formal approval, Nixon requested a yearly $200 budget in order to rent the Whittier Women's Club building for large social functions for the student body.

This way, the hardline Quakers could turn a blind eye or be completely oblivious of what was actually happening at those "meetings." And at the same time, the students could get their dances.

Over the following six months of his presidency, Nixon used the $200 to organize eight ballroom dances. He Ran an Orange Juice Company Once.

After taking the bar exam, Nixon became a lawyer in Whittier. But being a small community, there wasn't much work to be had and he wasn't making much money either, leading him to be oftentimes bored.

Then, in 1938, he was approached by two local businessmen who proposed that the three of them start an orange juice business. He agreed, formed a company named CitriFrost, and was elected president.

The idea behind the business was to produce freshly squeezed orange juice, add some sugar and gelatin, and then quick-freeze it. It was supposed to last indefinitely, and once defrosted, it would taste just like fresh orange juice.

Nixon gathered investments from mostly friends and family, added $1,000 of his own money, putting together a total of about $10,000 for the company's capital. But things were not to last, however, as CitriFrost ran into problems soon enough.

"Our product was good, the market was there, but we were doomed to fail for reasons beyond our control," he once recalled.

Ply film, the material in which the orange juice was packed, was becoming scarce around the country as the demand for it grew.

They nevertheless were able to get some good orders, but were unable to deliver as some their shipments broke down on transit.

Moreover, some disgruntled employees filed a lawsuit against the company, leading to Nixon and his fellow owners to pay them out of pocket.

In order to somehow save the company, he gave another $700, offered his legal services free of charge, had his father also work at the company for several weeks without pay, and finally ended up cutting and squeezing oranges himself day and night before finally closing the business down.

Friends of his recalled how distraught he was about the whole affair, particularly regarding his investors. Years later he even offered to pay them back.

Even though he was only in his mid-twenties, the whole affair affected him deeply and he declined any future offers of an executive position in a company. He Also Applied for the FBI.

As of 2014, the National Archives contains Richard Nixon's application to the bureau. It happened in 1937, one year before the orange juice business, when Nixon was 24-years-old and just before he was about to graduate from Duke University.

He was contacted for an interview one month after graduation, and even completed a physical exam at the request of the director of the FBI, J.

But as fate would have it, he didn't receive any response back and the rest is history. Well, not exactly – there are a few other things we do know.

In 1954, when Nixon was Vice President of the USA, he spoke at the annual FBI National Academy's graduation.

Hoover was also the one who introduced him on stage, saying that it was a pleasure for him to do so, knowing that the VP had previously applied.

The director also said during the graduation that Nixon, "Having already embarked upon the practice of law, the FBI's loss ultimately became the country's gain," referencing Nixon's not being part of the bureau.

But at a later party during his vice presidency, Nixon approached Hoover again, wanting to know why exactly he was never notified about his application.

Hoover then reopened his file at the FBI and saw that the Vice President was actually accepted, but his appointment was revoked one month later, in August 1937.

The reason for not hiring him, Hoover said, was because the bureau made some budget cuts that year.

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