Herb Kressel: Hi.
This is Herb Kressel, Editor of Radiology and welcome to the October 2017 Radiology
podcast.
Today, I'm delighted to be joined by Professor Hildo Lamb who is Professor of Radiology at
the Leiden University in Holland, and who with his colleagues, actually in Leiden and
throughout the Netherlands, wrote a very stimulating paper entitled, "Is Hepatic Triglyceride Content
Associated with Aortic Pulse Wave Velocity and Carotid Intima-Media Thickness?
The Netherlands Epidemiology of Obesity Study."
Welcome, Dr. Lamb.
Thanks for joining us again.
Dr. Lamb: Yeah, thank you for another opportunity.
Dr. Kressel: It's a pleasure.
So, first thing's first.
What exactly is The Netherlands Epidemiology of Obesity Study?
Dr. Lamb: It's a large cohort study that we initiated in 2008, so now almost ten years
ago and we included more than 6,000, it's almost 7,000 patients in total and about one-third
of those patients also had imaging and in that imaging part, we had different randomizations.
One of the randomizations was to image the aorta and the cardiovascular part, but also
some of them were included in the arm to measure the carotid IMT, the intima-media thickness
and lots of other things like blood work, neurologic testing, and all kinds of things
that were not included in this paper, but for this particular topic we ended up with
almost 2,000 patients for the statistical analysis.
Dr. Kessel: Right.
So can you just share with us the specific study rationale?
Why did you target this particular content?
Why would one expect that hepatic triglyceride content should independently be associated
with pulse wave velocity and/or carotid artery intimal wall thickness?
Dr. Lamb: At first this seems a really strange association that you might think, "Well, what
has the liver to do with the cardiovascular system?"
It was actually based on experiments some time ago based on dietary interventions where
we observed sort of co-variants in lipid levels in the liver and normal cardiovascular function
and vessel stiffness and then we developed this concept in the end that we think that
all over in the body the process is more or less the same, like in atherosclerosis.
So first, you may have fat accumulation, then in response you develop inflammatory processes
and based on that you have collagen formation and scarring.
So what we thought maybe that the liver is the central organ in this process and that
the liver actually directs all these changes all over in the body.
So the idea was to study the link between fatty liver and other organs and in this case
we were interested in two separate processes - the vessel stiffness and as a separate process
atherosclerosis by measuring the intima-media thickness by ultrasound.
Dr. Kessel: So blame it all on the liver.
Dr. Lamb: Yeah, maybe that's a good thing to remember.
Dr. Kessel: The liver is the root of all of joy and problems.
Okay.
Very interesting.
So another thing that some of those listening and viewing the podcast may be curious about,
can you tell us a little more about pulse wave velocity alterations in the aorta and
what's the presumed mechanism of this in relation to atherosclerosis and to brain changes as
well?
Dr. Lamb: In general, it's a complicated process.
The name is also difficult, pulse wave velocity, but what it actually means is that we tried
to measure the propagation of the ampules by the heart ejection.
So we do not measure the flow or the flow volume.
It's just measuring how the blood propagates through the aorta and you can compare this
for example by water flowing through a pipe.
If the pipe is very stiff, the transportation time of the water from the pump to the distal
end of the tap is very fast, so the speed of the water is very high and if you have
a more elastic tube like the aorta and when you're young and healthy, then it will be
a little bit dampened and the speed of the fluid is decreased a little bit.
So high pulse wave velocity reflects a stiff pipe and in this case stiff aorta, and the
idea is that this is maybe related to atherosclerosis, but we are not sure if this is really the
cause or effect.
We think that this is related to the balance between the elastin in the vessel wall and
the collagen level and we also know that this ratio is different between the central part
of the arteries and the peripheral arteries.
For example, there is a difference between the central aorta and the peripheral vessels
like the carotid artery where we measured intima-media thickness.
Dr. Kessel: I see.
Very good.
Now, a little more about your study design.
What did you actually do to study your hypothesis and study the associations?
How did you choose the cohort?
Did you have any subjects with elevated triglycerides who were not obese, as this is primarily the
obesity study.
So how did you go about answering the question you asked?
Dr. Lamb: Well, the only major inclusion criteria was to be healthy or that you don't have
a real known cardiovascular disease or diabetic disease, but actually it was a quite open
study.
So also we included normal people with normal BMI and also we had people in the overweight
category between a BMI of 25 and 30, and obesity group with a BMI higher than 30.
And based on the results of blood measurements in the patients, the blood work, we afterwards
corrected the findings.
So for example, we also included the lipid work, the lipid levels, use of lipid lowering
medication, and we used all this data to detect confounding factors in our statistical model.
So actually everybody was welcome in the study and afterwards we were using the statistical
tricks and that is possible because it's a relatively large cohort.
Dr. Kessel: Yes.
So if you can tell us, briefly summarize your key findings.
Dr. Lamb: The key finding is best shown in Figure 2.
That is the easiest way to understand.
So actually what we found is that if you have higher triglyceride content in the liver,
so you have a fatty liver, that also the vessel stiffness or the pulse wave velocity is higher.
Also on the other end of the spectrum, we slowed that with a lower BMI and with low
liver fat, that also your pulse wave velocity is lower.
So this confirms the feeling we had from previous studies and small studies that in this large
cohort we indeed have an association or some sort of statistical link at least between
the fat level in the liver and vessel stiffness.
On the other hand, we also found relation between the carotid intima-media thickness
that was a little bit higher in the patients with higher liver fat.
Then it's always difficult to interpret these statistical numbers, so for the intima-media
thickness it means that in the real world if you have a ten-fold increase in your fat
level in the liver, then a 15 micrometer increase in your intima-media thickness happens.
So that's the way - how you have to interpret these results.
The same is true for the vessel stiffness, for the pulse wave velocity.
So if this fat level in the liver increases ten-fold, then you have about a 0.2 increase
in your meter per second speed of vessel stiffening.
So that's how you can look at these numbers.
Dr. Kessel: Good.
So can you kind of review how you identified this as independent of the other features
of the metabolic syndrome?
Dr. Lamb: Yeah, that's always nice of those larger cohort studies that you can use all
the information you have and run different models.
So what we normally do is start with the crude model, that's usually model 1, also in this
study.
Then we chose to use model 2 to check the confounding effects of general things like
age, sex, blood pressure, heart rate, but also alcohol use, smoking habits, use of antihypertensive
drugs, lipid-lowering drugs.
So that's model 2.
And then on top of that, we were more specifically interested in the factors determining the
metabolic syndrome.
That was model 3.
And in model 4 it was everything and also on top of that the visceral adipose tissue
and the total body fat.
And actually in that model 4 all the factors we could imagine are included there that could
confound the results and even in that situation, we had a significant correlation or association
between the liver fat and the pulse wave velocity and the liver fat and the intima-media thickness
of the carotid arteries.
Dr. Kessel: So are these models basically regression analyses or is it-
Dr. Lamb: No, mainly ANOVA linear analysis.
Dr. Kessel: Very good.
Now one thing I noticed is that you had a - at least it was termed - a high failure
rate in the acquisition of MR spectroscopy, which you used as the metric for hepatic fat,
and with approximately a third of the patients there wasn't usable data.
What do you think this was due to?
Not allocating sufficient time for the exam or some lack of training?
Dr. Lamb: That's an interesting question.
I think it's mainly due to the technical challenges you have to perform spectroscopy studies in
general.
In the liver it's one of the easiest variants of that.
In the heart, for example, it's much more complicated.
So we had a learning curve for the technicians.
That was one factor.
So in the beginning, they missed out a lot of scans because you have to perform it with
and without water suppression and sometimes we had two spectra with water suppression,
two spectra without water suppressions, so that was a problem in the beginning and it
was also a reason why we started developing newer techniques, so now in new studies we
prefer to use the imaging-based Dixon-like techniques where you have a very easy setup
and everybody can do the scan.
Dr. Kessel: I see.
Well, that certainly makes sense.
And you mentioned looking at the lipid-lowering drugs.
What was the effect of these when you kind of analyzed it in the regression models?
Dr. Lamb: Yeah, for the parameters we studied, that actually then - the difference between
model 1 and 2, there was an effect.
The significance of the model went down of the beta actually of the association, but
still it was statistically significant.
So there was an effect, but it did not explain the relation fully between the fatty liver
and the vessel stiffness and the IMT thickness.
Dr. Kessel: Okay.
So they sort of moved down the curve of the response curve if you will.
Dr. Lamb: Yeah.
Dr. Kessel: Okay.
And going forward, what do you think are the potential clinical and public health implications
of your findings other than everyone should control their weight?
Are there other implications?
Dr. Lamb: Yeah, there is one interesting pathophysiological finding that's a little bit more detailed,
but we found a difference between the IMT measurements association because there was
an effect of visceral fat.
Actually, when we included visceral fat in model 4, the relation between the liver fat
and IMT thickness was not significant anymore, but in the vessel stiffness, it didn't matter.
So the significance even got better.
So this may indicate that the pathophysiological process behind atherosclerosis is a little
bit different, different pathway, different factors than the vessel stiffening itself.
On the other hand, if you are very practical, we know from literature and we performed a
couple of those studies before, that there is still hope because if you do a diet, then
also the pulse wave velocity changes.
So it is still reversible if you are in a sort of sweet spot area.
Dr. Kessel: Well, thank you very much.
This is very exciting work and we look forward to seeing the results of your future manuscripts
and thank you so much for joining us today.
Dr. Lamb: Okay.
Thank you very much.
Dr. Kessel: You're welcome.
Bye bye.
Dr. Lamb: Bye bye.
For more infomation >> Hepatic Triglyceride Content Is Associated with Aortic Stiffness - Duration: 14:40.-------------------------------------------
The Smothering - Steven Universe Fan episode - Duration: 13:48.
Careful Steven, don't bite down, you'll break the thermometer.
Ah, 98.6, good, nothing to worry about.
Uhh, Peridot. Do we really have to do this everyday? I mean, couldn't we, maybe, do the health check ups - Once a week?
No, this is fine. It's better to gather data as frequently as possible
Y'know Data's not going to stop me from getting sick again.
It's good to be prepared Steven.
Ok but, I just don't want you to waste too much time worrying about me.
*SNORT*
You can't waste time worrying
*WARP PAD ACTIVATES*
We're back
Hey Jasper, hey Lapis!
STEVEN! put that knife down, you'll cut yourself!
Hey guys...
Jasper: Hello Steven Lapis: Hey Steven!
Jasper: Did you sleep well?
Yeah I slept pretty great!
At least until Peridot woke me up again with her health check up
Health checkup? Are you sick?
You don't look sick
No, I'm not sick. Peridot's just been doing health check ups on me everyday since I caught that cold.
You're still doing that?
Yes I'm STILL doing that Jasper. Unlike SOME gems I actually care about Steven's safety.
We all care about Steven Peridot, you're just being overbearing
I AM NOT OVERBEARING!
I'm maternal
Steven, tell her
well you did take my second pillow away, cuz you said it might be...
...dangerous
I was worried about you being smothered in your sleep. Anyway you don't need two.
It was nicer with two though.
For someone so worried about smothering you seem to be doing a lot of it
Lapis: OOOOOoooooohhhhh
*Deep breath*
Jasper.
don't you perhaps have something
HEAVY, you need to be...
MOVING AROUND?
Steven. We're going out now to go on a mission, would you like to come with us?
I can go on the mission?!
Peridot: WHAT!?
*THUMP*
S-Steven can't go on mission! It's too dangerous, he's not ready, he doesn't have any of his powers, he can't-
Jasper: I ASKED! Steven...
Don't worry Steven, we'll be there to protect you.
Yeah Steven come with us, it'll be great!
You'll get to see us fight a giant monster up close!
Perdot: NO HE WON"T! He has to stay at a reasonable distance.
I wanna go on the mission!
Ah, Steven your first mission! You're gonna have so much fun!
Steven & Lapis: *Happy Laughter*
STEVEN WAIT!
You're still wearing your pajamas!
Okey Steven, let's wee here while Jesper and lapis scout ahead that way
We'll always be close to the war pad, and he's anything dangerous happens. Hey Steven come look at this. It's super gross, okay
What is this stuff we don't know it's some kind of slime residue made by the monster we were tracking
It's harmless to us, but it's killing all the plants around here plus. It's totally gross
Lapis don't get that muck away from him there could be
infectious
peridot
Lazuli lapis don't you dare?
Over here
Climb across
Mmm
Stay calm Steven use your arms to balance and walk slowly pearl if you need to
Careful Steven
Stephen when you're in the field
It's important to obtain as much knowledge of the area as possible so though you have the tactical advantage to crush your opponent's
Get on top of that vantage point tell me if you see anything important
What do you see
Well, I can see a lot of things I can see a big lake over that way
There's a bunch of rocks and what looks like more broken pillars up ahead
And then there's what kind of looks like a big clearing where surgeries are falling down
That was close you could have fallen and seriously damaged your cranium at least you were wearing your helmet
Hey, Steven want me to fly you around and look for the monster. Do I great we'll go right now
Peridot what are you? Don't worry peridot? I'll be fine. I'm with lapis whoa
I'm okay
She'll be fine. Oh
Hey, there's another river, and it's filled with gross slime stuff hey that must be where the monster is
Let's go get it whoa
Lapis shouldn't we wait for the others it'll be fine Steven come on it, but it's over here
Lapis I'm not so sure and it even come look lapis
Are you excited Steven if your very first official mission monster isn't it cool?
Yeah, it's pretty cool. Like I guess I just didn't think it would be so
funny
You want to see me beat it up
Okay, sure
Hey, you wanna bubble the gym I can bubble Jones probably try it out
Stephen you did it you bubbled your first gem we should go show Jasper repaired on ok
Hey guys look what Stephen did I bubbled a gym Stephen? You're helpful. Even you
Okay good mission everyone well done Stephen time to go home. Oh
Isn't this better Stephen nice and safe nothing dangerous
Capable of lately preferred in your bio matter you must be so relieved to be home
Well you've had a busy day Stephen time for bed, but it's not even lunchtime yet, Oh Stephen you and your
food
Okay, you can have lunch, but then you have to put on your pajamas and go to bed
Well
Steven
Home Easter Steven. I thought your heart had malfunctioned. Oh, and you spill your milk really Steven
You know better than a meat snacks in the dark
Peridot you don't have to apologize Steven. I'll clean this up, and you can just go back to bed
I'll tuck you in when I'm done
I'm not tired. What was that Steven? I said, I'm not tired are
You upset about your milk Steven, it's okay. We can go down and get you some more tomorrow. I'm not upset about the milk
I'm upset because you wouldn't let me do anything all day even though it was my first mission
and then you maybe go to bed at lunchtime and
It is tomorrow, which is why I'm not tired
Steven I be not so sure I like your tone young man
Stephen you've contaminated your plasma. Oh Stephen Stephen. Where are you going?
Stephen you can't activate the
Even even come back here, you're not even married shoes
Look even what are you doing?
Even please get down from there. It's dangerous keep it on yourself or better yet
Just be still and I'll get you down peridot
Peridot I'm really sorry I scared you. I know that you worry a lot when you think I'm in danger from rocks
Or we're getting sick or being on missions, and I know it's because you care
But you can't always be there to protect me from all that stuff. You need to let me do some things on my own
You okay, buddy
My head hurts
Well you did fall off of rock that
Stephen I
Realizing me a bit a bit
constraining with you lately, so I am going to be making an effort to allow you more freedom to
Learn on your own does this mean you're gonna stop doing health check-ups of course not even you just got concussed
Hmm, but after you get better we can change it to once a week like you wanted oh
Okay, hey can I have my second pillow back?
Cool
My head still hurts
-------------------------------------------
Catch the mother of all news t...
For more infomation >> Catch the mother of all news t...-------------------------------------------
Uomini e Donne, accesa lite tra Gemma, Marco e Gianfranco: ecco il motivo | K.N.B.T - Duration: 4:13.
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Uomini e Donne, Soleil: il retroscena sul Grande Fratello Vip - Duration: 3:49.
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Uomini e Donne, trono over: grande abbandono in arrivo? - Duration: 3:58.
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Mare e Monti day 6 (6/10) - Duration: 4:01.
leaving the gite
today a short walk to Serriera
first 100 meters up in the village
this is were we ended the trail yesterday
strange marker
nice view the first hour
but also bush paths
from here a detout to Partinello only 15 minutes
No coffee in this village :(
back on trail again
it's really a sunny day today
the last descent today
and now 250 meters down to Serriera
this is a nice village with a shop and snackbar
arrived at gite l'Alivi
tonight we share this clean room with 3 others
-------------------------------------------
Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.
HELLO GUYS, A LOT OF PEOPLE ASK ME
ABOUT HAPPINESS AT WORK,
"OH I'M NOT HAPPY DOING
WHAT I'M DOING, MY JOB,
I'M NOT HAPPY". SO I STOP TO THINK
IF THIS PERSON KNOW WHY SHE'S DOING THAT OR
WHAT THE PROPOSE OF HER WORK
WHAT WOULD YOU DO
IF YOU COULD DO SOMETHING FOR FREE ?
AND IT MAKES YOU GLAD,
.....GIVE YOU A BIG PLEASURE....
I THINK THIS IS THE BIG SEARCH
WHEN YOU DO SOMETHING YOU LOVE,
AND SOMETHING THAT THE WORLD NEEDS,
THIS IS YOUR " MISSION "
WHEN YOU REALLY DO SOMETHING THAT THE WORLD NEED,
AND THE WORLD IS ABLE TO PAY YOU FOR THIS
IT'S WHAT I CALLED "VOCATION "
YOU REALIZED WHAT THE WORLD ABLE
TO PAY YOU...
...FOR THIS, AND REALLY MAKE....
...THIS HAPPENED
YOU TURN THIS INTO YOUR " JOB "
AND WHEN YOU ARE DOING
WHAT YOU LOVE, IT'S YOUR "PASSION "
WHEN YOU DISCOVERED YOU " PASSION, MISSION,
....JOB AND VOCATION "
AND FIT IN INTO YOUR LIFE,
YOU REALIZED WHAT IS YOU " GIFT "
THAT IN PORTUGUESE IS " DOM "
WHEN YOU DISCOVERED YOUR GIFT,
YOU ARE FINALLY ABLE TO WORK THE REST
OF YOUR LIFE INTO SOMENTHING YOU...
......LOVE
AND I ENSURE THAT YOU WILL BE...
VERY HAPPY
........
GO TO MY WEBSITE,
THERE'S EVERYTHING THAT I TOLD YOU HERE
AND SUBSCRIBE BECAUSE
REALLY NICE THINGS WILL COME FOR WE THINK TOGETHER
THANKS
-------------------------------------------
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UND Mortar Board Volleyball Fundraiser - Duration: 0:45.
Mortar Board is a senior Honor Society not only on the campus of UND but in
over 200 campuses nationwide.
Thanksgiving is a time for family, food, reflecting on what you're thankful for
and mortarboard would like to help families in the greater Grand Forks area
be able to afford that for some of those who cannot. I chose this particular
volleyball tournament to just get involved with my campus and just have
some fun be a part of the UND community.
Last year alone we gave out 1,200 baskets.
We're hoping to give out even more this year.
-------------------------------------------
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Overview: Report Packages Part I in Oracle Enterprise Performance Reporting Cloud - Duration: 5:20.
In this two-part overview we'll show you
the highlights of report packages.
In part one, we'll discuss what report
packages are, and why to use them, and
we'll discuss their components such as
doclets, sections, and development phases.
Part two examines these development phases
in more detail. Performance reporting is
a critical function in most companies.
Whether the reports are internal reports
for board packages, management updates,
quarterly updates, or external reports
like statutory, regulatory, filing, or
annual, the ability to gather information
from various sources, review it for
accuracy, and present it to the intended
audience is a core function of business.
Creating reports is easy with one author
and no required review, but having
multiple authors working on report can
be more complicated. Do all of the
authors have the current version?
How do you merge changes from multiple
authors into a single document? As you
add content creators, giving everyone
organized becomes more challenging.
The situation can become even more difficult
with several authors, multiple reviewers,
each of whom might be responsible for
different sections, and multiple signers
who provide final sign-off on the whole report.
How do you keep all of your
authors, approvers, reviewers, and signers organized?
How do you handle versioning
and manage workflow?
Coordinating stakeholders by email can
be daunting. A better way to organize and
produce a collaborative report is by
using a report package.
So, what is report package? A report package is a
reporting construct that enables you to
structure the content of your report,
assign responsibilities to content
creators and reviewers, and manage their
collaboration and workflow to produce a
unified document.
Report packages help you manage the
lifecycle of your deliverables.
With them you can assign content to
multiple authors,
gather comments from reviewers, provide
an electronic sign off on the completed
report,
manage the report life cycle by
providing notifications to users
managing the workflow, and coordinating
the processes, combine data points with
textual narrative, and secure and control
access to the report content enabling
users to see only the content that they
are permitted to see, at the time that
they are permitted to see it.
Next, let's look at some key components
of a report package. Report packages
enable you to divide reports into sub
components called doclets. What makes up
a doclet varies depending on the type of
report that you are creating. For example,
a sales report might have separate
doclets for each geographical region, and
a financial disclosure might have
doctorates for each of the various
financial statements, tax statements, and notes.
You assign doclets to authors who
then provide content.
Sections enable you to group doclets for
organization or to keep documents
together that have a common format or
are intended for a common viewership.
For example, you can group all financial
statements in a report into one section.
This provides a filtered view of only
those documents to the reviewers
assigned to that section.
Report package development occurs in
three phases. The author phase enables
you to compile the various report
content and supporting details together
into a cohesive report package.
The review phase allows you to gather
commentary on multiple draft versions
and to revise the report content accordingly.
The sign-off phase provides
the ability to gather electronic
signatures from key stakeholders and to
secure report content to prevent further
modifications. You decide which
development phases your report requires.
Is the report content going to be
provided primarily by one or two people?
Then you may not require an author phase.
Is your report being developed for a
small group of internal stakeholders?
Then you may not require a review phase.
You can tailor the development phases to
the type of report that you require.
In part 1 of this topic we defined report
packages and their components, and we
discuss the many benefits of using them
within your organization. In part two, we
will look at the developmental phases in
a little more detail. To learn more about
Enterprise Performance Reporting Cloud Service,
visit the link shown here.
-------------------------------------------
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Hepatic Triglyceride Content Is Associated with Aortic Stiffness - Duration: 14:40.
Herb Kressel: Hi.
This is Herb Kressel, Editor of Radiology and welcome to the October 2017 Radiology
podcast.
Today, I'm delighted to be joined by Professor Hildo Lamb who is Professor of Radiology at
the Leiden University in Holland, and who with his colleagues, actually in Leiden and
throughout the Netherlands, wrote a very stimulating paper entitled, "Is Hepatic Triglyceride Content
Associated with Aortic Pulse Wave Velocity and Carotid Intima-Media Thickness?
The Netherlands Epidemiology of Obesity Study."
Welcome, Dr. Lamb.
Thanks for joining us again.
Dr. Lamb: Yeah, thank you for another opportunity.
Dr. Kressel: It's a pleasure.
So, first thing's first.
What exactly is The Netherlands Epidemiology of Obesity Study?
Dr. Lamb: It's a large cohort study that we initiated in 2008, so now almost ten years
ago and we included more than 6,000, it's almost 7,000 patients in total and about one-third
of those patients also had imaging and in that imaging part, we had different randomizations.
One of the randomizations was to image the aorta and the cardiovascular part, but also
some of them were included in the arm to measure the carotid IMT, the intima-media thickness
and lots of other things like blood work, neurologic testing, and all kinds of things
that were not included in this paper, but for this particular topic we ended up with
almost 2,000 patients for the statistical analysis.
Dr. Kessel: Right.
So can you just share with us the specific study rationale?
Why did you target this particular content?
Why would one expect that hepatic triglyceride content should independently be associated
with pulse wave velocity and/or carotid artery intimal wall thickness?
Dr. Lamb: At first this seems a really strange association that you might think, "Well, what
has the liver to do with the cardiovascular system?"
It was actually based on experiments some time ago based on dietary interventions where
we observed sort of co-variants in lipid levels in the liver and normal cardiovascular function
and vessel stiffness and then we developed this concept in the end that we think that
all over in the body the process is more or less the same, like in atherosclerosis.
So first, you may have fat accumulation, then in response you develop inflammatory processes
and based on that you have collagen formation and scarring.
So what we thought maybe that the liver is the central organ in this process and that
the liver actually directs all these changes all over in the body.
So the idea was to study the link between fatty liver and other organs and in this case
we were interested in two separate processes - the vessel stiffness and as a separate process
atherosclerosis by measuring the intima-media thickness by ultrasound.
Dr. Kessel: So blame it all on the liver.
Dr. Lamb: Yeah, maybe that's a good thing to remember.
Dr. Kessel: The liver is the root of all of joy and problems.
Okay.
Very interesting.
So another thing that some of those listening and viewing the podcast may be curious about,
can you tell us a little more about pulse wave velocity alterations in the aorta and
what's the presumed mechanism of this in relation to atherosclerosis and to brain changes as
well?
Dr. Lamb: In general, it's a complicated process.
The name is also difficult, pulse wave velocity, but what it actually means is that we tried
to measure the propagation of the ampules by the heart ejection.
So we do not measure the flow or the flow volume.
It's just measuring how the blood propagates through the aorta and you can compare this
for example by water flowing through a pipe.
If the pipe is very stiff, the transportation time of the water from the pump to the distal
end of the tap is very fast, so the speed of the water is very high and if you have
a more elastic tube like the aorta and when you're young and healthy, then it will be
a little bit dampened and the speed of the fluid is decreased a little bit.
So high pulse wave velocity reflects a stiff pipe and in this case stiff aorta, and the
idea is that this is maybe related to atherosclerosis, but we are not sure if this is really the
cause or effect.
We think that this is related to the balance between the elastin in the vessel wall and
the collagen level and we also know that this ratio is different between the central part
of the arteries and the peripheral arteries.
For example, there is a difference between the central aorta and the peripheral vessels
like the carotid artery where we measured intima-media thickness.
Dr. Kessel: I see.
Very good.
Now, a little more about your study design.
What did you actually do to study your hypothesis and study the associations?
How did you choose the cohort?
Did you have any subjects with elevated triglycerides who were not obese, as this is primarily the
obesity study.
So how did you go about answering the question you asked?
Dr. Lamb: Well, the only major inclusion criteria was to be healthy or that you don't have
a real known cardiovascular disease or diabetic disease, but actually it was a quite open
study.
So also we included normal people with normal BMI and also we had people in the overweight
category between a BMI of 25 and 30, and obesity group with a BMI higher than 30.
And based on the results of blood measurements in the patients, the blood work, we afterwards
corrected the findings.
So for example, we also included the lipid work, the lipid levels, use of lipid lowering
medication, and we used all this data to detect confounding factors in our statistical model.
So actually everybody was welcome in the study and afterwards we were using the statistical
tricks and that is possible because it's a relatively large cohort.
Dr. Kessel: Yes.
So if you can tell us, briefly summarize your key findings.
Dr. Lamb: The key finding is best shown in Figure 2.
That is the easiest way to understand.
So actually what we found is that if you have higher triglyceride content in the liver,
so you have a fatty liver, that also the vessel stiffness or the pulse wave velocity is higher.
Also on the other end of the spectrum, we slowed that with a lower BMI and with low
liver fat, that also your pulse wave velocity is lower.
So this confirms the feeling we had from previous studies and small studies that in this large
cohort we indeed have an association or some sort of statistical link at least between
the fat level in the liver and vessel stiffness.
On the other hand, we also found relation between the carotid intima-media thickness
that was a little bit higher in the patients with higher liver fat.
Then it's always difficult to interpret these statistical numbers, so for the intima-media
thickness it means that in the real world if you have a ten-fold increase in your fat
level in the liver, then a 15 micrometer increase in your intima-media thickness happens.
So that's the way - how you have to interpret these results.
The same is true for the vessel stiffness, for the pulse wave velocity.
So if this fat level in the liver increases ten-fold, then you have about a 0.2 increase
in your meter per second speed of vessel stiffening.
So that's how you can look at these numbers.
Dr. Kessel: Good.
So can you kind of review how you identified this as independent of the other features
of the metabolic syndrome?
Dr. Lamb: Yeah, that's always nice of those larger cohort studies that you can use all
the information you have and run different models.
So what we normally do is start with the crude model, that's usually model 1, also in this
study.
Then we chose to use model 2 to check the confounding effects of general things like
age, sex, blood pressure, heart rate, but also alcohol use, smoking habits, use of antihypertensive
drugs, lipid-lowering drugs.
So that's model 2.
And then on top of that, we were more specifically interested in the factors determining the
metabolic syndrome.
That was model 3.
And in model 4 it was everything and also on top of that the visceral adipose tissue
and the total body fat.
And actually in that model 4 all the factors we could imagine are included there that could
confound the results and even in that situation, we had a significant correlation or association
between the liver fat and the pulse wave velocity and the liver fat and the intima-media thickness
of the carotid arteries.
Dr. Kessel: So are these models basically regression analyses or is it-
Dr. Lamb: No, mainly ANOVA linear analysis.
Dr. Kessel: Very good.
Now one thing I noticed is that you had a - at least it was termed - a high failure
rate in the acquisition of MR spectroscopy, which you used as the metric for hepatic fat,
and with approximately a third of the patients there wasn't usable data.
What do you think this was due to?
Not allocating sufficient time for the exam or some lack of training?
Dr. Lamb: That's an interesting question.
I think it's mainly due to the technical challenges you have to perform spectroscopy studies in
general.
In the liver it's one of the easiest variants of that.
In the heart, for example, it's much more complicated.
So we had a learning curve for the technicians.
That was one factor.
So in the beginning, they missed out a lot of scans because you have to perform it with
and without water suppression and sometimes we had two spectra with water suppression,
two spectra without water suppressions, so that was a problem in the beginning and it
was also a reason why we started developing newer techniques, so now in new studies we
prefer to use the imaging-based Dixon-like techniques where you have a very easy setup
and everybody can do the scan.
Dr. Kessel: I see.
Well, that certainly makes sense.
And you mentioned looking at the lipid-lowering drugs.
What was the effect of these when you kind of analyzed it in the regression models?
Dr. Lamb: Yeah, for the parameters we studied, that actually then - the difference between
model 1 and 2, there was an effect.
The significance of the model went down of the beta actually of the association, but
still it was statistically significant.
So there was an effect, but it did not explain the relation fully between the fatty liver
and the vessel stiffness and the IMT thickness.
Dr. Kessel: Okay.
So they sort of moved down the curve of the response curve if you will.
Dr. Lamb: Yeah.
Dr. Kessel: Okay.
And going forward, what do you think are the potential clinical and public health implications
of your findings other than everyone should control their weight?
Are there other implications?
Dr. Lamb: Yeah, there is one interesting pathophysiological finding that's a little bit more detailed,
but we found a difference between the IMT measurements association because there was
an effect of visceral fat.
Actually, when we included visceral fat in model 4, the relation between the liver fat
and IMT thickness was not significant anymore, but in the vessel stiffness, it didn't matter.
So the significance even got better.
So this may indicate that the pathophysiological process behind atherosclerosis is a little
bit different, different pathway, different factors than the vessel stiffening itself.
On the other hand, if you are very practical, we know from literature and we performed a
couple of those studies before, that there is still hope because if you do a diet, then
also the pulse wave velocity changes.
So it is still reversible if you are in a sort of sweet spot area.
Dr. Kessel: Well, thank you very much.
This is very exciting work and we look forward to seeing the results of your future manuscripts
and thank you so much for joining us today.
Dr. Lamb: Okay.
Thank you very much.
Dr. Kessel: You're welcome.
Bye bye.
Dr. Lamb: Bye bye.
-------------------------------------------
The Smothering - Steven Universe Fan episode - Duration: 13:48.Careful Steven, don't bite down, you'll break the thermometer.
Ah, 98.6, good, nothing to worry about.
Uhh, Peridot. Do we really have to do this everyday? I mean, couldn't we, maybe, do the health check ups - Once a week?
No, this is fine. It's better to gather data as frequently as possible
Y'know Data's not going to stop me from getting sick again.
It's good to be prepared Steven.
Ok but, I just don't want you to waste too much time worrying about me.
*SNORT*
You can't waste time worrying
*WARP PAD ACTIVATES*
We're back
Hey Jasper, hey Lapis!
STEVEN! put that knife down, you'll cut yourself!
Hey guys...
Jasper: Hello Steven Lapis: Hey Steven!
Jasper: Did you sleep well?
Yeah I slept pretty great!
At least until Peridot woke me up again with her health check up
Health checkup? Are you sick?
You don't look sick
No, I'm not sick. Peridot's just been doing health check ups on me everyday since I caught that cold.
You're still doing that?
Yes I'm STILL doing that Jasper. Unlike SOME gems I actually care about Steven's safety.
We all care about Steven Peridot, you're just being overbearing
I AM NOT OVERBEARING!
I'm maternal
Steven, tell her
well you did take my second pillow away, cuz you said it might be...
...dangerous
I was worried about you being smothered in your sleep. Anyway you don't need two.
It was nicer with two though.
For someone so worried about smothering you seem to be doing a lot of it
Lapis: OOOOOoooooohhhhh
*Deep breath*
Jasper.
don't you perhaps have something
HEAVY, you need to be...
MOVING AROUND?
Steven. We're going out now to go on a mission, would you like to come with us?
I can go on the mission?!
Peridot: WHAT!?
*THUMP*
S-Steven can't go on mission! It's too dangerous, he's not ready, he doesn't have any of his powers, he can't-
Jasper: I ASKED! Steven...
Don't worry Steven, we'll be there to protect you.
Yeah Steven come with us, it'll be great!
You'll get to see us fight a giant monster up close!
Perdot: NO HE WON"T! He has to stay at a reasonable distance.
I wanna go on the mission!
Ah, Steven your first mission! You're gonna have so much fun!
Steven & Lapis: *Happy Laughter*
STEVEN WAIT!
You're still wearing your pajamas!
Okey Steven, let's wee here while Jesper and lapis scout ahead that way
We'll always be close to the war pad, and he's anything dangerous happens. Hey Steven come look at this. It's super gross, okay
What is this stuff we don't know it's some kind of slime residue made by the monster we were tracking
It's harmless to us, but it's killing all the plants around here plus. It's totally gross
Lapis don't get that muck away from him there could be
infectious
peridot
Lazuli lapis don't you dare?
Over here
Climb across
Mmm
Stay calm Steven use your arms to balance and walk slowly pearl if you need to
Careful Steven
Stephen when you're in the field
It's important to obtain as much knowledge of the area as possible so though you have the tactical advantage to crush your opponent's
Get on top of that vantage point tell me if you see anything important
What do you see
Well, I can see a lot of things I can see a big lake over that way
There's a bunch of rocks and what looks like more broken pillars up ahead
And then there's what kind of looks like a big clearing where surgeries are falling down
That was close you could have fallen and seriously damaged your cranium at least you were wearing your helmet
Hey, Steven want me to fly you around and look for the monster. Do I great we'll go right now
Peridot what are you? Don't worry peridot? I'll be fine. I'm with lapis whoa
I'm okay
She'll be fine. Oh
Hey, there's another river, and it's filled with gross slime stuff hey that must be where the monster is
Let's go get it whoa
Lapis shouldn't we wait for the others it'll be fine Steven come on it, but it's over here
Lapis I'm not so sure and it even come look lapis
Are you excited Steven if your very first official mission monster isn't it cool?
Yeah, it's pretty cool. Like I guess I just didn't think it would be so
funny
You want to see me beat it up
Okay, sure
Hey, you wanna bubble the gym I can bubble Jones probably try it out
Stephen you did it you bubbled your first gem we should go show Jasper repaired on ok
Hey guys look what Stephen did I bubbled a gym Stephen? You're helpful. Even you
Okay good mission everyone well done Stephen time to go home. Oh
Isn't this better Stephen nice and safe nothing dangerous
Capable of lately preferred in your bio matter you must be so relieved to be home
Well you've had a busy day Stephen time for bed, but it's not even lunchtime yet, Oh Stephen you and your
food
Okay, you can have lunch, but then you have to put on your pajamas and go to bed
Well
Steven
Home Easter Steven. I thought your heart had malfunctioned. Oh, and you spill your milk really Steven
You know better than a meat snacks in the dark
Peridot you don't have to apologize Steven. I'll clean this up, and you can just go back to bed
I'll tuck you in when I'm done
I'm not tired. What was that Steven? I said, I'm not tired are
You upset about your milk Steven, it's okay. We can go down and get you some more tomorrow. I'm not upset about the milk
I'm upset because you wouldn't let me do anything all day even though it was my first mission
and then you maybe go to bed at lunchtime and
It is tomorrow, which is why I'm not tired
Steven I be not so sure I like your tone young man
Stephen you've contaminated your plasma. Oh Stephen Stephen. Where are you going?
Stephen you can't activate the
Even even come back here, you're not even married shoes
Look even what are you doing?
Even please get down from there. It's dangerous keep it on yourself or better yet
Just be still and I'll get you down peridot
Peridot I'm really sorry I scared you. I know that you worry a lot when you think I'm in danger from rocks
Or we're getting sick or being on missions, and I know it's because you care
But you can't always be there to protect me from all that stuff. You need to let me do some things on my own
You okay, buddy
My head hurts
Well you did fall off of rock that
Stephen I
Realizing me a bit a bit
constraining with you lately, so I am going to be making an effort to allow you more freedom to
Learn on your own does this mean you're gonna stop doing health check-ups of course not even you just got concussed
Hmm, but after you get better we can change it to once a week like you wanted oh
Okay, hey can I have my second pillow back?
Cool
My head still hurts
-------------------------------------------
Catch the mother of all news t... For more infomation >> Catch the mother of all news t...-------------------------------------------
Saab 9-5 2.0T SE **Eerste Eigenaar** Automaat** - Duration: 1:00.
For more infomation >> Saab 9-5 2.0T SE **Eerste Eigenaar** Automaat** - Duration: 1:00. -------------------------------------------
Volkswagen Crafter €. 2.904,- voordeel. L3H3 3.5 T 2.0 TDI 140 pk (vsb 14937) Rijklaar! - Duration: 0:58.
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Funny And Lucky Moments - Hearthstone - Ep. 294 - Duration: 5:43.
For more infomation >> Funny And Lucky Moments - Hearthstone - Ep. 294 - Duration: 5:43. -------------------------------------------
Bungo Stray Dogs | Dangerous - Duration: 1:09.
Good evening.
Evil expects evil from others.
This is not for the eyes of children.
The bad guys' enemy.
-------------------------------------------
Little Achievements (social anxiety/selective mutism) - Duration: 5:21.
(whispered) cat!
Um. Hey guys!
Um, very quick update video, um, with two-
- that's four-
two anxiety achievements
Well.
I tried to film another video about the first achievement last week, but
somehow in the middle of the video I just
stopped talking, I just... Suddenly, it locked-
(sighs) Well.
So, I'm just gonna report the achievement of last week and the one from today.
I'm not sure what's going on today?
Well, last saturday I was, um, at an optician
to finally get new glasses,
because I used to have glasses, but I haven't worn them in a few years,
I only wear them when I go to see a movie
because they're so uncomfortable...
But I actually need glasses...
I pushed it aside, I didn't want to do it because it would
involve so much talking,
explaining why I haven't done it earlier...
Well.
I went last saturday, that's an achievement in itself
that I finally, um, well- did it?!
And I did most of the talking on my own, I know, that
would be normal - should be normal for a twenty three year old,
...yes, I just had to think about how old I am.
But it isn't- It isn't normal, it isn't easy for someone, well, with social anxiety and selective mutism, okay?
(laughs nervously)
But I confidently talked to them,
even though I was very embarassed,
and I had to explain "Yeah, well, my eyesight is-
much worse than it used to be when I got these glasses that I have here,
yeah, I know I can't see with these glasses because, um,
the last time I got my eyes checked was six years ago and since then I haven't done shit because I was scared."
It was all very embarassing, but it was okay because
it was two nice old ladys,
and - yeah, sorry to say it, but it wasn't a man, and...
That makes it easier. For some reason it's easier to talk to old ladies instead of men any age.
(mumbled) I'm sorry.
(quietly) Yeah, it's not something I choose or can control, so...
Anyway! I did that - talked a lot, maybe even more than I had to...
Yeah, I-
I talked a lot when I was nervous, that's-
What?! Me?! (laughs)
I talk a lot when I'm nervous?!
I'm usually the kind of person that doesn't talk at all when I'm nervous, when I get anxious.
But I talked so much! Probably too much!
Which probably isn't good either, but hey!
It's an achievement, it's a success - for me.
(laughs) And well, today-
um, today is tuesday-
my family and I went to a restaurant
and...
I ordered my food! On my own! (nervous laugh)
and the waiter didn't have to ask
"Excuse me?"
which usually always happened when I ordered something.
(very quietly, almost inaudible) "Sorry, I would like..."
(normal voice) "Sorry?"
(still very quiet, a little louder than before) "I would like- this- and then that-"
(normal voice) "Excuse me..?"
(my normal voice from here) Or my parents would just order it for me to start with because
this shit would happen.
And today, really, I ordered my stuff, they didn't have to ask, they got me the first time,
(laughing)
And I even asked a question!
(laughs) I know!
Um, I asked a question about something in the menu,
and then I was too scared to ask another, more important question, but-
yeeeah. Okay.
It was still okay.
It wasn't that bad, it was just- the first question was what kind of tea they had,
what I could order,
and the second question would have been
what veget- vegetables are on this vegetarian pizza.
I should have probably asked that and not the tea question because I got a pizza with mushrooms.
Eh, it was still okay, there was still a lot on the pizza that I liked, that I could eat and,
the whole thing didn't taste like mushrooms when I took them and gave them to my mom.
(sighs) Yeeeah, okay. But I asked one question, I
couldn't bring myself to ask the other question, but
Hey, okay, it's... It's- It's a little success.
It's okay.
And...
obviously, I'm still alive. I didn't die, I didn't feel like I was dying (relieved laugh)
I felt like I was dying last saturday, and that's
unfortunately not being dramatic. It was that bad. I really couldn't breathe properly for
half an hour.
And this time it's okay.
I'm not dying. (laughs)
I did two things that I'm scared of and
I did well.
Somehow.
-------------------------------------------
New Huge Jurassic World Surprise Egg For Kids / T-Rex Vs Indominus Rex / Raptor Unboxing - Duration: 1:12:24.
Wow okay it's great to see you again
we're gonna have another awesome giant
surprise toy opening today inside the
giant egg we have a lot of awesome
surprises but first of all guys let's go
ahead and take a look around us because
well I did was I like the drastic world
toys so much I went and bought almost
all of them again brand-new so I could
have them brand new in boxes on top of
all the other ones I have because guys
as of June this year they will not be
made anymore Hasbro has lost the license
so as of June this year you will not
find these on shelves anymore and the
prices will probably skyrocket so if you
do I know a Toys R Us still has a few of
them and some other stores have some ah
if it's something you're interested in
it in guys buy it soon Amazon still has
I'll put a link below this video where
you could get some of these on Amazon
they probably have the best prices there
so ah go ahead and check that out
but anyways don't wait guys because they
will be gone forever
okay let's see what is inside the giant
magical surprise egg Wow
okay are you guys ready wow this is
gonna be fun oh wow check this out it's
a whole container of 25 good dinosaur
characters Wow I have
I've seen good dinosaur toys in a while
guys this is gonna be awesome
let's go ahead and see what we have in
here although to tell you the truth I'm
not really sure if I'm gonna remember
all of the characters names so I might
need some help from you guys okay so
first of all we have our load and I
believe we have yep this is our laws dad
you could tell because the heads like oh
he's got like a square shaped head so
his head shape is different that Arlo's
okay so there is two of them and who is
neck okay here we have three members of
the t-rex family you've got butch you
got Vivienne and do you guys remember
what the third dinos name is if you do
drop me a comment I'm not going to tell
you I want to see if you guys remember
what it is okay and then we have four
thunderclaps if you remember thunderclap
was the pterodactyl that kept trying to
eat spot so he is a mood let's go ahead
move he's aside okay then we have four
book characters if you remember butch
was the velociraptor it was totally
clueless she's like good my name is
butch but remember what my name is
I forgot what yeah yeah yeah it's and
then strangely enough this one comes
with the cattle from the movie - oh
there was one more like the long horn
cattle and then we have three
Stegosaurus do you remember what her
name was
I'm thinking Alice but I could be wrong
God if you do know what it is let me
know in the comment section and then to
triceratop Vivien's or someone blue or
white and then three ankylosaurus is so
if you guys remember this one's name to
all it look cool and then the final one
is the Triceratops that has really fancy
horns and this guy is forrest woodbush
no no i'm wondering if he is a
triceratops he might not be because I'm
only seeing two horns there okay then
this next one is awesome
it was actually too big to fit into the
egg this is ash like set this is from ah
world of history dinosaurs this is set
for two to six three it includes a t-rex
on the hood so you got a t-rex
you got a skull a baby t-rex and an egg
also go ahead and open this up and check
it out does this look totally cool okay
so first of all you got the cute little
baby t-rex so this little guy looks
really cute and he feels soft I'm
surprised at how soft this guy feels and
then it comes with a little clear egg
that I guess he's supposed to hatch shut
up so this guy fits right into the egg
so you could have him hatching out of
the egg and then you have a cool
Triceratops skull check this thing out
you could actually open and close it
there and a bone like a chewed bone hear
that
the Triceratops is eating actually to
bone that the t-rex is eating
sorry not Triceratops and then the try
the t-rex wow this guy is awesome this
is one of the coolest like T Rex's I
have seen I am totally impressed check
this guy out and this guy is very
realistic feeling the texture and is
some type of like almost I think it's
plastic but it almost feels like it has
like a rubber membrane on the top so it
does feel very realistic you've got like
some type of a crown here on his head
spots on his neck really great paint job
on inside and out really good detail on
the tongue the teeth are incredible it's
like individual teeth and they are
painted so nice big claws on the hand
the legs and the bottom of this guy is
super good detailed check out the
striations and everything on this feet
beautiful paint job Wow seriously this
is one of the nicest dinos I've seen
come from Schleich and it is huge and SH
likes like makes a really nice set guys
I mean this guy is totally awesome wow
that was a cool set okay and last but
not least from the giant egg we are
going to pull this bag of 15 surprise
Jurassic world dinos I showed you one of
these bags before but this is a brand
new one you can see it's sealed here I'm
going to go ahead and open this for you
guys right now I bought several of these
bags because once again that's another
thing that's going to disappear off
forever
once the license runs out in June so
here they do come sealed in these little
triangle up like packages so I'm going
to go ahead and open them up so we could
check them out okay and then these do
come in this awesome
bag here says Jurassic world is open for
business visitors from around the world
can't wait to experience the thrill and
all of the actual dinosaur and guys ah
once Jurassic world two toys come start
coming out I will review all of them for
you I'm super excited because Mattel is
taking over so I think they're actually
going to do a much better job than a
Hasbro has okay so here is the
Triceratops this guy is awesome the
detail on these little ones is totally
cool and then that's a gray one then we
have a dark like a green and a really
light green Triceratops also
and each of these does have the little
JW logo there and then let's see what
else we have oh we have a red and yellow
t-rex you can see he's got the yellow
stripe on the bottom with tiny little
beady eyes some of these the paint job
is great some of them is not that great
but these are awesome sets did you get a
chance to buy these guys buy them Oh a
really cool Mosasaurus he's like tan
gold blue and black awesome and you know
I I do like the detail on these little
guys like I said the paint job is
questionable on some of some of them but
the detail is really cool here we've got
a gray and silver velociraptor like I
said they do all have the little JW logo
on it oh we have an endo - Rex this
guy's like a greenish brown color the
thing is each one of these packages is
guaranteed to have at least one
indominus rex so it looks like this one
does have just one some of them have
more than one and then we have couple
awesome spinosaurus this guy's like a
tan and gold color Spinosaurus is
probably one of my favorite dinos if I
have to pick three I would pick t-rex on
dominance rex and spinosaurus i do got
the big Spinosaurus toy from jurassic
world the animatronic one that one is
totally awesome and I'd done a lots of
videos with
and I also reviewed it if you want to
check out my Jurassic world or Jurassic
Park playlists okay so another same
Spinosaurus and then here we have
another one of the grey and silver
velociraptors so the detail is good on
these two I mean they have the third
claw and everything so that is cool then
we have a pterodactyl actually this
would be I believe a Pteranodon so here
it does also have the little JW this is
like a green it's a little bit of red on
the crown we have a die more food on so
this guy's cool it's like brown with
blue spots and some black colors on him
and what do we have here I believe this
one is an Allosaurus
[Music]
so that guy's cool he's like red and
black stripes and then we have a
pachycephalosaurus these guys like dark
green like a greenish almost like a
greenish tan color on top so that guy's
really cool there then we have aa
ankylosaurus this guy's like all one
color got like the spikes in the club
tail and everything and they do paint
kind of little beady black eyes on that
guy and then last of all we have a mega
soros this guy's like brown on the place
on his back of like gray then he's got
like the big spikes he uses to attack
with so there we have it guys ah those
were the dinos that we had today so we
had an awesome surprise egg if you guys
did enjoy the video please go ahead and
click like and the thumbs up you guys
are a great audience guys I really
appreciate you guys watching over the
years and if you guys if there's any new
viewers are viewing I do got a lot of
dinosaur videos dinosaur battles guys go
to the Jurassic world playlist at the
end of the video there's a lot of fun
videos over there and if you do want to
buy any of the drastic world toys like I
said I'll put a link below the video
ah to where you could buy them on Amazon
I am affiliated with Amazon which means
I get a small sales commission but it
costs you the exact same amount as if
you just went on Amazon so if you use my
link you'll be getting some awesome toys
and also helping to support my channel
and let me know which one of these are
unopened toys you see here is your favor
I think mine is the original indominus
rex that is one you already are not
going to find anymore
I mean that one I think I paid
seventy-five dollars on eBay to get that
guy new again so it's sad but that one's
going to be hard to find but a lot of
these other ones you could still find so
you have until June so time is Rudy Gow
thanks guys and I will see you guys soon
Wow guys that was a lot of fun and if
you enjoyed the video make sure you
click Subscribe and the thumbs up button
down below the video and today secret
word is the word go ahead and put that
in the comment section down below the
video on those you remember my club go
to the video ends there's and also then
curves off more fun with you click the
boxes below for a lot more fun videos
and if you want to see even more go
ahead and click the subscribe button
-------------------------------------------
South Indian Actress - 25 South Actresses | Age | Height | Weight | Body Measurement * Part 2 * - Duration: 3:56.
Please Check Video Description For Details
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North Korea news: Japan insists it WON'T shoot down Kim Jong-un's missiles - Duration: 2:53.
North Korea news: Japan insists it WON'T shoot down Kim Jong-un's missiles
has fired two rockets over Japan in recent months. One of the rockets was an. Japan did not attempt to shoot down the missiles on either occasion despite the flyover sparking sparking loudspeaker alerts and TV warnings telling citizens to take cover.
Minister of defence Itsunori Onodera today said that there was no need for action as the rockets didn't pose a threat to Japan.
He said: "The recent missile tests by North Korea passed at high altitude and there was no fear of them falling in our territory or territorial waters so we did not shoot them down.
"Whether it is Japan or any other country, I think that shooting down a ballistic missile could be construed as a military action.
"Unless you judge it is an attack on your own country, I think it is difficult to shoot down such missiles.".
Mr Onodera has ruled out shooting down missiles in the future – giving Pyongyang the go ahead for further tests, sparking fears for World War 3 amid escalating tensions between the rogue state and America.
Just last month Japans Chief Cabinet Secretary Yoshihide Suga said the nation will not tolerate the repeated and excessive provocations". Earlier today if it doesn't back down on sanctions against the communist state.
The North Korean leader issued the rounds of threats while blasting , calling him a "headless chicken" and "suicidal". to "goods, funds people and technology if it continued to test nuclear weapons.
This sparked fury from Kim, who retaliated by saying: "Japans such rackets inciting the tension of the Korean peninsula is a suicidal deed that will bring nuclear clouds to the Japanese archipelago.
"No one knows when the touch-and-go situation will lead to a nuclear war, but if so, the Japanese archipelago will be engulfed in flames in a moment. This is too self-evident." .
-------------------------------------------
Descobrindo seu DOM / Discovering your GIFT - Duration: 2:00.HELLO GUYS, A LOT OF PEOPLE ASK ME
ABOUT HAPPINESS AT WORK,
"OH I'M NOT HAPPY DOING
WHAT I'M DOING, MY JOB,
I'M NOT HAPPY". SO I STOP TO THINK
IF THIS PERSON KNOW WHY SHE'S DOING THAT OR
WHAT THE PROPOSE OF HER WORK
WHAT WOULD YOU DO
IF YOU COULD DO SOMETHING FOR FREE ?
AND IT MAKES YOU GLAD,
.....GIVE YOU A BIG PLEASURE....
I THINK THIS IS THE BIG SEARCH
WHEN YOU DO SOMETHING YOU LOVE,
AND SOMETHING THAT THE WORLD NEEDS,
THIS IS YOUR " MISSION "
WHEN YOU REALLY DO SOMETHING THAT THE WORLD NEED,
AND THE WORLD IS ABLE TO PAY YOU FOR THIS
IT'S WHAT I CALLED "VOCATION "
YOU REALIZED WHAT THE WORLD ABLE
TO PAY YOU...
...FOR THIS, AND REALLY MAKE....
...THIS HAPPENED
YOU TURN THIS INTO YOUR " JOB "
AND WHEN YOU ARE DOING
WHAT YOU LOVE, IT'S YOUR "PASSION "
WHEN YOU DISCOVERED YOU " PASSION, MISSION,
....JOB AND VOCATION "
AND FIT IN INTO YOUR LIFE,
YOU REALIZED WHAT IS YOU " GIFT "
THAT IN PORTUGUESE IS " DOM "
WHEN YOU DISCOVERED YOUR GIFT,
YOU ARE FINALLY ABLE TO WORK THE REST
OF YOUR LIFE INTO SOMENTHING YOU...
......LOVE
AND I ENSURE THAT YOU WILL BE...
VERY HAPPY
........
GO TO MY WEBSITE,
THERE'S EVERYTHING THAT I TOLD YOU HERE
AND SUBSCRIBE BECAUSE
REALLY NICE THINGS WILL COME FOR WE THINK TOGETHER
THANKS
-------------------------------------------
How to Send WhatsApp Voice Messages Using Google Assistant - Duration: 2:02.
How to send whatsapp voice messages using Google assistant to get started
touch and hold the home button on your Android phone or from the google app
itself and simple say okay Google send message to Mike from whatsapp chat with
Mike sure what's the message hey Mike I need to talk to you call me as soon as
possible got it do you want to send it or change it send it it's on its way
okay Google send message to Mike from whatsapp chat with Mike sure what's the
message cancel it okay no problem okay Google send message
to Mike okay message to Mike do you want to use SMS or whatsapp whatsapp message
to Mike using whatsapp sure what's the message name's Walter Hartwell white I
live at 308 negra arroyo lane albuquerque new mexico got it do you
want to send it or change it cancel it
okay no problem get more info from Google assistant to web find all you
need to get started with Google assistant thanks for watching and stay
tuned for next videos Cheers
-------------------------------------------
Fibromyalgia - causes, symptoms, diagnosis, treatment, pathology - Duration: 7:29.
The term fibromyalgia can be broken down.
Fibro- refers to fibrous tissue, -my- refers to muscle and -algia refers to pain.
Fibromyalgia is a chronic condition, which occurs more often in women, that causes widespread
muscle pain, extreme tenderness in various parts of the body, and sleep disturbances.
Normally, if a person cuts their finger, a specific type of sensory neuron called a nociceptor
or pain receptor, converts that stimulus into an electrical signal.
These are the first neurons and they're primarily found in the skin, joints, or the
walls of organs.
The electrical signal goes from the dendrite of the nociceptor into its peripheral axon
branch and heads up the hand and arm towards its cell body.
The cell body is located in the dorsal root ganglion which is a cluster of nerve cell
bodies located in a dorsal root of the spinal nerve.
The dorsal root ganglia contains the cell bodies of many sensory neurons that receive
information.
So in this case, the cell body would receive the electrical signal, and if it's strong
enough, it would start to release substance P, which is a small chemical involved in pain
perception.
Substance P would go down the other axon branch of the nociceptor and would get released from
the neuron's terminal button.
Substance P then binds to receptors on a second neuron which has its cell body located in
the dorsal horn of the spinal cord, which makes up the back portion of the spinal cord
that receives sensory information.
There is also a separate group of neurons called inhibitory neurons in the spinal cord
that dampen or reduce the pain response, counteracting the effect of nociceptors.
These inhibitory neurons release neurotransmitters such as serotonin and norepinephrine and they
also act on the second neuron in the spinal cord to inhibit the pain signal.
If the signal from the nociceptors is greater than the signal from the inhibitory neurons,
then it triggers the second neuron in the spinal cord to fire an action potential.
This electrical signal goes all the way up the spinal cord to the brain where the pain
is perceived.
So while, the pain signal races towards the brain, important events are happening in the
damaged finger as well.
Epithelial cells near the damaged area start to release nerve growth factor.
That nerve growth attracts nearby mast cells which start to release even more nerve growth
factor - amplifying the effect.
The high levels of nerve growth factor do a few important things to nociceptors.
It boosts the growth, makes them more sensitive to pain, and makes them produce even more
substance P.
In fibromyalgia, the underlying mechanism isn't well understood, but there seems to
be a problem with how the brain receives pain signals.
Generally speaking, individuals have low levels of serotonin, which is involved in inhibiting
pain signals, and elevated levels of substance P, and nerve growth factor, which are involved
in propagating pain signals.
Together, these are thought to play a role in the hypersensitivity to pain, which hints
that fibromyalgia might be a condition of central sensitization.
In other words, if a person with fibromyalgia were to cut their finger, they would perceive
more pain compared to other people.
In addition, central sensitization means that a person might have a wide range of sensitivities
- affecting everything from how they sleep to how they feel to how they think.
If the person with fibromyalgia has negative emotions like depression, anxiety, and psychological
factors like negative beliefs and attributions it can also amplify this sensitivity to pain.
Fibromyalgia often runs in families so there seems to be a strong genetic link too.
And environmental factors like child abuse are also linked to fibromyalgia.
Diagnosis of fibromyalgia is generally based on a few factors.
First, there's pain in at least seven or more areas of the body, with a symptoms severity
scale score of at least five points out of a possible twelve.
The symptoms severity scale gives points for a wide range of symptoms - everything from
difficulty concentrating and remembering things - sometimes called "fibro fog" to fatigue
to poor sleep and waking up unrefreshed and having a headache.
Alternatively, there might be pain in at least five or more areas of the body, with a symptoms
severity score of at least nine points out of a possible twelve.
Additionally, the symptoms have to be present for at least three months, of course, the
pain cannot be due to another disorder.
Treatment of fibromyalgia requires a holistic approach.
Regular exercise like cardiovascular fitness training which includes fast walking, biking,
swimming, or water aerobics can help by reducing pain and fatigue.
Relaxation techniques and good sleep hygiene can also help.
If these approaches don't work, medications can be used.
For example, amitriptyline, and serotonin-norepinephrine reuptake inhibitors, or SNRIs, can help by
elevating serotonin and norepinephrine levels.
Finally, anticonvulsants like pregabalin and gabapentin which slow nerve impulses can help
with sleep problems.
All right, as a quick recap, fibromyalgia is a long-lasting condition that causes widespread
muscle pain, excessive tenderness in many areas of the body, and sleep disturbances.
And people with fibromyalgia have a lower threshold to pain.
The diagnosis is often made with a clinical history which shows over three months of widespread
pain that cannot be due to another disorder.
Treatment of fibromyalgia involves in easing symptoms to improve the quality of life.
In some people, regular exercise and sleep may reduce pain and fatigue.
In other people, antidepressants, like SNRIs reduce symptoms.
-------------------------------------------
BlingGuard Dots Stabilizing Earring Supports - Duration: 3:35.
For more infomation >> BlingGuard Dots Stabilizing Earring Supports - Duration: 3:35. -------------------------------------------
FABFILTER PRO Q 2 TUTORIAL (SUBTRACTIVE EQ) - Duration: 15:06.
hi guys welcome to another tutorial today I'll be talking about subtractive
EQ with fabfilter pro-q to fabfilter pro-q 2 is a high-quality equalizer
plug-in with unrivaled sound and interface available in VST VST 3au axr
tas and audio suit formats
if you don't use fabfilter pro-q you should it's a really good EQ Scott music
function sounds pretty great for digital thank you alright so open up your
project in Ableton or whatever the AWU are in
are you sable certain reason let's talk about what subtractive EQ is
there are two types of Equalization there's additive EQ and subtractive EQ
subtractive EQ it's the process of removing frequencies in order to make
room for other frequencies on another instrument additive EQ is turning up
frequencies in an instrument usually to help fill out the frequency range in the
instrument and hopefully in this song the reason you want to do subtractive EQ
is to clean up your tracks obviously so I'm going to show you guys how to do
that this probably won't be as accurate as I normally to buy e queuing
so there's a lot of things we could EQ there the most obvious thing to do would
be to roll off the highs and 808 nothing too crazy so for that I mean we could
really just use a stock Ableton for that but I'll show you guys how to do in fat
filter since this is going to be a fabfilter tutorial it's a dragon
fabfilter if you want to trigger a high shelf you double click over here
over here and on we'll create a high shelf you double-click in the middle it
will create a bell
and meet locals for now from there I played with the gain and the frequency
until I found something I liked and after that you can play with the
percentage here to change how much you want it to be affecting the track
okay name that I cut
now we're gonna do the offset here to the sample let's just meet the drums -
for now so we're gonna do the same thing as we did on the other side click on
this second line here and it will create a low shelf
and basically from there you can just drag this point around until you find
somewhere you like and if you have a middle mouse scroll you can use that to
change the cue
I would say around there it's pretty good
and labeled my track there cut low for bass I'm going to bring in the kick now
just a kick kick sample and base
velocity not sure if I have to do any subtractive EQ to clean out the room for
the kicks cut through the sample because it seems to be cutting through alright I
think I may want to move some highs from that kick nothing too drastic just so
sound shape it a little bit so I'm gonna do the same thing I did earlier create a
high shelf then drag it around I find that sweet spot
I should decide to create a second shelf here to see if I could shape it a little
more
I'm gonna change the percentage a little bit to try fitted in mix
it's perfect right there
quite often you'll have to cut room on your sample or since for your kick I'll
show you guys what that would look like well I do not think it's really
necessary here I'll show you guys anyways
it might look something like that
or like this
or even some crazy shit like this
okay back to what we're actually working on though
now it's time to bring in the hi-hat it definitely cut some lows on that
so I decided to do a little shelf and we're bringing some way to fuck up
because I think it's mostly high frequencies but it could use some
shaping it does sound a little low
sounds pretty good right there this is a very drastic setting by the way I would
I would almost out like more more often tonight probably way more down here for
most high hats this one is very strange so you know don't copy me exactly it
just go by here but these are all like guidelines kind of some basic guidelines
formulas whatnot techniques okay now we're gonna do some to the snare I mean
it sounds pretty good
when you're doing any sort of mixing or subtractive EQ it could really help to
turn to up the volume or turn down the volume overall just to get an ear for
how different it could send a sample still has a lot of loads kind of fucked
so I'm going to undo some more subtractive EQ to that
yes not enough we're gonna have to call him for the big guns
no more shelves here we have to go for a fucking a goddamn filter
ok so double-click over here again create a little shelf and then we're
going to turn it into a low-cut and then you can change the queue or the
shape of it here with their middle scroll
and adjust that until cut out any unwanted base you can also change the
amount it's cutting here or any of these I believe there's some very extreme
settings here look at this 96 decibels per octave jesus fucking christ
definitely allow this background noise of that sample
spring the base back in may want to cut some room for the hi-hat in the sample
also so let me do that now
so usually the hi-hats will be anywhere from like two K to ten plus K
the sounds so you're usually gonna want to try to figure out where you're gonna
want to cut you can either do some sort of additive technique try to find it
there's definitely something at 6k here
some gonna do some subtraction here
basically I move it around so I can hear the hi-hat coming through a little
clearer because if you have it a little too high it sounds a little too sharp
and you have it a little too low it sounds a little too flat so usually I
try to bounce it around so I find a nice little happy medium just setting a
little bit you can also cut a room for other instruments as well I feel like
these are all I need to really do for this though
alright guys how's my tutorial on how to do subtractive EQ with fabfilter pro-q -
hope you guys enjoyed that thank you for watching don't forget to comment like
subscribe if you guys have a checked out on music make sure you go check that out
I'll see you guys next time peace
-------------------------------------------
This is the Part Where He Kills You - Defeating Wheatley and going to the Moon in Portal 2 END - Duration: 2:11:34.
For more infomation >> This is the Part Where He Kills You - Defeating Wheatley and going to the Moon in Portal 2 END - Duration: 2:11:34. -------------------------------------------
Enterprise Concert Confessional with Fitz and The Tantrums - Duration: 1:48.
What up everybody, it's Fitz from Fitz and The Tantrums.
Hey everybody, this is Noel of Fitz and The Tantrums.
And this is our Concert Confession.
We are going to surprise some of our fans. They don't know that we're here
and hopefully they don't, I don't know punch me or something.
Every single time I'm in the car I always have some kind of music playing.
We have all Fitz and The Tantrums' music downloaded on our Spotify.
Inspiration that I find when driving is normally
because I have the opportunity to listen to as much music as possible.
Sort of fed into the way we make our music.
Just me in the car, singing as loud as I can 'cause no one's around.
One of the most personal songs has to be "The Walker."
Whenever I was feeling down or you know, things were happening in life, I would just listen to that one.
Because it's sort of an anthem for the inner freak in all of us.
"Hand Clap" is definitely my favorite song by them.
"Hand Clap."
I love Fitz and The Tantrums because the vibe they put on when they perform is just so energetic.
They're catchy and if I introduce them to someone,
it's getting someone else into that music.
They kind of give you the energy to go through your day.
Their music - it's so different than what's out now.
If I could meet Fitz and The Tantrums, I would say...
Thanks for making this memory for me. This is my kid's first concert.
It'd really make me happy.
You're making a big, huge memory for my family.
Oh my God.
Oh! Oh my God!
Hi! Oh my goodness!
Hi! Oh my God.
Don't cry!
This is incredible.
Let's hug it out!
We wouldn't be in the place that we are
living out our dreams without the support of those fans.
Thanks Enterprise for bringing us closer to fans, and we'll see you out on the road.
-------------------------------------------
10 Deaths Caused by Video Games - Duration: 6:00.
10 Deaths Caused by Video Games
Playing video games is such a universal college practice that schools might as well issue
minors in gameplay.
And for most people, gaming is a great way to unwind, kill time, or hang out with friends.
Yet for some — the few, the proud, the mentally unbalanced — video games are the spark held
to the powder keg that sets them off.
Not every death tied by the media to video games is actually related to them, but the
ones on this list make for gruesome exceptions.
It's worth reiterating that most gamers are the rational sort, and those who are pushed
over the edge by games are usually already falling and just looking for an excuse to
lose control.
1.
Alayiah Turman:
Tyrone Spellman is one of the worst people you'll ever read about.
A man in love with his Xbox, Spellman went apopleptic when his 17-month-old daughter,
Alayiah, accidentally pulled the cords out of the wall.
Rather than ensure the child's safety or just fix things and move on, Spellman cracked
her skull repeatedly, killing her.
He got up to 47 years in prison for the crime.
2.
Shawn Woolley:
Online RPGs are known for their addictive qualities — players get so obsessed that
they devote all their time to the game, often at the expense of a social life — but rarely
have they had an effect like they did on Shawn Woolley.
He killed himself in the fall of 2001, and his mother attributes the death to a lack
of reality and socialization encouraged by Everquest.
3.
Ace Mealer, James Crump, Arnold Strickland:
In June 2003, a teenager named Devin Moore, who was a big fan of the Grand Theft Auto
series, went on a killing spree.
He'd been brought to a police station on suspicion of stealing a car, at which point
he grabbed a gun, shot two officers and a 911 dispatcher, and grabbed a set of car keys
as he made a speedy exit.
He drove off in a police cruiser but was quickly captured.
When caught, he reportedly said, Life is like a video game.
Everybody's got to die sometime."
Classy guy.
4.
Aaron Hamel:
Chalk up another one for Grand Theft Auto (it's understandable why so many critics
complain of the game's cop-killing stories): Aaron Hamel was killed and Kimberly Bede was
injured when two stepbrothers in Tennessee, aged 14 and 16, opened fire with rifles they'd
found in their home.
The boys cited Grand Theft Auto III as the inspiration for their real-life destruction.
5.
Zhu Caoyuan:
In 2004, Shanghai gamer Zhu Caoyuan was murdered by fellow player Qiu Chengwei in a dispute
over a "cyber-weapon."
Qiu won the weapon in the online game Legend of Mir III and loaned it to Zhu to use in
the game, after which Zhu turned around and sold it.
Jerk move, to be sure, but when cops told Qiu they couldn't help him because the stolen
property wasn't real, Qiu confronted Zhu and stabbed him in the chest, killing him.
Qiu earned a death sentence with the possibility of having it commuted to life if he behaved.
6.
An unnamed Russian man:
Lineage II is a pretty typical MMORPG, which means it's capable of inspiring pointless
feuds that bleed over into real life.
Case in point: when a pair of Russian guilds got into an online shouting match over the
killing of one of their characters, the players opted to settle the score on their own.
They met for a fight that got so bloody one man died of his injuries on the way to the
hospital.
7.
Dylan Lee Edmondson:
Dylan Lee Edmondson was 3 years old when he died in October 2010.
His mother, Alexandra Tobias, was a FarmVille junkie who was engrossed in the popular Facebook
game when her son started crying.
She shook him several times, likely hitting his head, causing his death.
She could get 25 years in prison.
8.
Xiao Yi:
Another disheartening suicide: Xiao Yi was 13 when he jumepd from the roof of a 24-story
building.
According to notes he left, the boy was entranced by the world of Warcraft III and hoped to
reunite with his online friends in the afterlife.
9.
Mai Thi Mau:
Dinh The Dan, 13, strangled and killed Mai Thi Mau, 81, in order to get money for video
games.
He used a piece of rope to choke her before robbing her and burying her in a pile of sand
at his house.
He wanted the money to pay for his online video game habit, so he decided to rob and
kill someone to get it.
The boy was sent to a "reeducation camp" in hopes of changing his behavior.
10.
An unnamed Chinese man:
Even by the standards of this list, this is a creepy, sad entry.
In 2007, a Chinese man played online video games for three days straight in an Internet
cafe.
That's 72 hours of consecutive gaming.
Even assuming breaks for food and relief, that can only end badly, and it did: after
three days, the man dropped dead from exhaustion.
Why did he do it?
What was he playing?
Did he have nowhere else to go?
Horrible questions with no answers.
-------------------------------------------
Mitten in São Paulo Polizei verhindert den "größten Bankraub der Welt" - Duration: 1:57.
For more infomation >> Mitten in São Paulo Polizei verhindert den "größten Bankraub der Welt" - Duration: 1:57. -------------------------------------------
10 Things You Won't Believe You Can Major In p2 - Duration: 5:25.
10 Things You Won't Believe You Can Major In p2
Culinary school isn't too weird a concept. You go there and you learn all the different ways to cook and then maybe get a low paying, high stress job in a restaurant.
But the advantage of it is that you learn all sorts of different ways to cook. At Kansas State, though, you can decide to instead focus on one of the most common ways to make food taste better: baking.
You can concentrate on either production management or cereal chemistry. Ok, we guess this is different from just a cooking degree and you might get a job in the food production industry.
But still, just… come on. Cereal chemistry? Who bakes their cereal? We know that's not what it means, but that's what it sounds like.
And what it sounds like is ridiculous. Do we really need some pinhead professor to tell us how to pour our Frosted Flakes?.
That's right, that was not a joke. This is an actual major at an actual college that you can actually major in.
If you thought the coolest people in The Big Lebowski were the people working at the alley, this major might be for you.
Most people in business get more general degrees than this, but if you know what you want maybe you should get really specific – like a degree in Bowling Industry Management.
The only college with this option is Vincennes University in Indiana. And if you get bored, take advantage of their onsite 18-lane bowling alley.
That's right: if you need to relax after class, head on over and knock down some pins. On second thought, this doesn't sound that bad. Winemaking.
People, as a general rule, like alcohol. Most adults drink at least once in awhile.
So, there's probably going to continue to be jobs for the people who make it. But is going to college really necessary to make wine? Well, some colleges think so.
In order to fancy it up even further, colleges actually call these programs Enology, which means the study of wine. Oh, it sounds so sophisticated.
Well, at least it will allow you to gain an intensive knowledge of what goes into making wine at the age of 18 or so. We're sure that you won't abuse that knowledge.
It's fascinating and useful to study other cultures. One of the most interesting things to study about other cultures is their mythology.
You can learn a lot about a society by studying their folklore. Yep, that's a great thing to read about in your spare time. But surely it isn't a full on major anywhere… right? Wait… it is?.
Ok, well it's probably some small school you've never heard of. Well, yes, if you've never heard of Harvard University.
That's right, the college everyone thinks of when they think 'prestigious' has a major in Folklore and Mythology. We suppose you can probably still get a good job with it, as long as you emphasize where you got the major.
"You majored in what? Oh, I don't think… oh, from Harvard. Oh yes, of course, can you start Monday?" We're assuming that's how it works, anyway. Whatever you want (Student-designed major).
Turns out, some colleges realize students might have interests that don't fit neatly within one college major. So, they give them the option to double major.
Or even maybe triple major. Or, if that doesn't work, some of them just let kids make up their own major.
At several universities, there exists what is called a student-designed major. The student decides what to call it and they get it put on their diploma if they do what the college tells them to, and they get through all their classes.
Of course, the college has to approve their choice, so it's not really whatever you want. But you can probably convince them of a lot of different things.
Maybe we should send some of our writers to school for listicle studies? That certainly would have been more helpful than our Bowling Management degree. Just to remind you, that's a real degree.
If you take just one thing from this article, let it be that. There are people getting a degree to prepare them for a career in the bowling industry. Come on!.
-------------------------------------------
Breaking: Scalise Issues Game-Changing Statement on Gun Control | Top Stories Today - Duration: 3:02.
Louisiana Republican and House Majority Whip Steve Scalise recently returned to Congress
with much fanfare after recovering from the nearly life-ending bullet to the hip he took
from a deranged liberal gunman at a GOP baseball practice in June.
Scalise sat down for an interview with Fox News host Martha MacCallum, and with the horrific
Las Vegas massacre having just occurred, was asked for his thoughts on the Second Amendment
and whether his position had changed in light of the Vegas incident and his own personal
experience, according to the New York Post.
"I think it's fortified it," the congressman said of his support for gun rights.
"Because first of all you've got to recognize that when there's a tragedy like this, the
first thing we should be thinking about is praying for the people who were injured and
doing whatever we can to help them, to help law enforcement."
"We shouldn't first be thinking of promoting our political agenda," he added, according
to the Washington Free Beacon.
"And I think we see too much of that where people say 'OK, now you have to have gun
control.'"
"First of all, look at some of those bills — those bills wouldn't have done anything
to stop this," he continued.
"That gunman actually cleared background checks so to promote some kind of gun control
is the wrong way to approach this."
Scalise proceeded to point out that it was Capitol Hill police officers with guns who
saved his life and other congressmen on that ball-field, and noted that countless gun-carrying
Americans similarly save the lives of themselves and others everyday.
"Regular citizens that just have a passionate belief in the Second Amendment that have their
own guns use guns every single day to protect themselves against criminals," he stated.
"And those stories never get told or hardly ever get told.
"But that's a different side of the story that I think is important," he added.
"People use guns way more to defend themselves from criminals than criminals using guns to
hurt people."
You can watch the entire segment below.
The portion specifically about gun control begins after the 5:00 mark:
Scalise nearly died when he was attacked out in the open by a rifle-wielding madman, and
some likely suspected that his brush with death may have had an effect on his stance
regarding gun rights.
However, rather than shift toward wanting more government controls over the rights of
the citizenry, Scalise made it clear that he "absolutely" still defends the Second
Amendment and that his stance in that regard has actually been "fortified" by his harrowing
experience.
As a final note, Scalise holds an "A+" rating from the National Rifle Association
and has lent his support to numerous pro-gun pieces of legislation, including the national
right-to-carry or nationwide reciprocity for licensed concealed carriers.
What do you think of what Scalise had to say about gun control?
Please share this news if you're glad Steve Scalise has recovered and is still standing
up for the Second Amendment.
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10 Things You Probably Didn't Know About Richard Nixon - Duration: 14:29.
10 Things You Probably Didn't Know About Richard Nixon
Nixon was a Quaker. For those of us who don't know, Quakers draw their roots from the Christian religion and first began in England in the 1650s.
The official name of the movement is the Religious Society of Friends, and there are currently around 210,000 Quakers around the world.
They strongly believe in peace, equality, social justice, freedom of choice, and in a strongly knit yet diverse community life. Quakers also seek to live a simple life so as to not put a great burden on the world.
They believe that God is love and every person can have a strong relationship with God without the need of a religious figure, like a priest or minister.
They don't regard any book as being the actual word of God, seeing the Bible as a great inspirational book, but at the same time, seeing others in the same way.
Now, even though they trace their roots back to Christianity, and outsiders see them as a branch of it, most Quakers actually see themselves as part of a universal religion that has many Christian elements to it.
Hannah Milhous Nixon, Richard Nixon's mother, was a devout Quaker who exerted a strong influence on her husband and children. When Nixon was 9-years-old, the family moved to the Quaker community of Whittier in California.
As a young boy, he attended church every Sunday, played the piano during the church services, attended chapel hours every day, and enrolled at Whittier College – which was a Quaker institution. Growing up, Nixon lived a modest life.
He recalled his childhood by saying, "We were poor, but the glory of it was we didn't know it." But after his mother's death in 1967, he never again attended any other church services.
In his memoirs, Nixon talks about his religion and its influence on him in only three paragraphs of the book.
These, together with some of the ways he acted as President of the United States, have led some to believe that he only used his pacifist religion to advance his political career and gather support for his bid at the presidency.
Nixon, College, Fraternities, Hazing, and Initiation Rituals.
Richard Nixon would have been considered a nerd by any modern standards. He was extremely diligent and studious.
And because of these traits, he was offered scholarships to both Harvard and Yale. But because of the Great Depression, and his older brother's tuberculosis flaring up, he wasn't able to attend either due to financial difficulties.
Instead, he went to local Whittier College. And even though he had a rather withdrawn personality, Nixon joined or took part in almost every club or event in sight.
Besides his usual classes and his time spent at his father's store, Richard was also part of the college's football team, dramatic society, the debating team, the college orchestra, student politics, the Glee Club, and attended events like basketball games, off-campus picnics, opera shows, and weekend skiing trips, among others.
As a Quaker college, Whittier forbade fraternities, seeing them as a sort of class distinction tool. But the better-off students found a loophole here and founded a men's student society known as the Franklins instead.
Its main purpose, of course, was to act as a fraternity in all but name, and show off their social elitism at every occasion.
Among Nixon's first actions as part of Whittier was to start an anti-establishment and anti-Franklins society known as the Orthogonians. Most of this society's activities revolved around being as different as possible from the Franklins.
When the "snobs" dressed in tuxedos to pose for group photographs, the Orthogonians would wear open-neck shirts. All of the society's founding members, Nixon included, were football players.
One of the only things Nixon particularly hated about college life was the hazing rituals as part of initiation to different societies and clubs.
One such Orthogonian joining ritual involved going into the woods near Whittier, digging up the corpse of a wild boar (the society's mascot), and eating some of its raw meat there on the spot.
But since wild boar corpses weren't so easily available in California, they exchanged it for a dead dog.
Since Nixon was a charter member, he never actually had to do it himself, but he had to be present whenever someone else did. One hazing ritual he did have to be involved in was when he joined the Glee Club.
He had to strip naked and then sit on a cake of ice. And every time he sat up, they would take a big paddle and smack him on the butt so it would warm up.
After he went through this hazing ritual, he got pneumonia. His father was outraged and intent on suing the other students, but Richard stopped him.
Overall, though, he said he had a great time in college. After Whittier, we went to Duke University School of Law. His First "Major" Political Victory.
Throughout his college years, Richard Nixon had a visible interest in politics.
He became president of his freshman class, then in his second year he became a sophomore representative on the student executive committee, and then vice president of the student body in his third year.
He won that election by a landslide victory with 267 votes to 73.
One of his fellow students later recalled something that Nixon said on a bus ride as part of the Glee Club trip: "You should never run for office from a city council base.
If you're going to go for politics, don't hang about with local politics, go for the big time." Of course, at the time, none of them had any idea of the foreshadowing they were presented with.
In any case, at the beginning of his fourth year in college, he placed his bid for the student body presidency, going against a student from the Franklins.
But while his opponent focused his campaign on a new student union building, old Dick Nixon focused on dancing.
Even though he was overall shy and an awkward dancer, he knew that the victory wouldn't come from the two opposing societies themselves, but rather from off-campus voters and the girl's dormitories.
So, by focusing his campaign on the overwhelmingly popular issue of ballroom dances, not only was he able to win the election, but even swing some of the Franklins to his side.
After a crushing defeat, his opponent said that, "His [Nixon's] issue had student appeal and I guess mine was a little too practical. It was the silver-tongued orator against a babbling idiot. Even if he didn't say anything it sounded good.".
Now, winning an election was one thing, but delivering on the promise was totally another. As a Quaker institution, Whittier forbade all ballroom dances, and because of that, Nixon's first proposal was immediately rejected by the college president.
But he then made an appeal to the trustees saying that it would actually be better and safer for the student's moral well-being to have dances on college campus under proper supervision, rather than going off to LA to dance at those Prohibition era-style speakeasy establishments there – something that they were already doing, by the way.
Amazed by his audacity of going over the college president's head, one trustee said: "Think of the nerve of this lad, appearing before the august body of the Board of Trustees at Whittier College in a plea for no dancing on the campus which the Quakers didn't look fondly upon at all.
It took a lot of guts and nerve and crust, I think, to do that. But he did it and convinced the board that they really ought to modify their policy.".
And to smooth the transition over, Nixon came up with a face-saving compromise.
Instead of asking for the board's formal approval, Nixon requested a yearly $200 budget in order to rent the Whittier Women's Club building for large social functions for the student body.
This way, the hardline Quakers could turn a blind eye or be completely oblivious of what was actually happening at those "meetings." And at the same time, the students could get their dances.
Over the following six months of his presidency, Nixon used the $200 to organize eight ballroom dances. He Ran an Orange Juice Company Once.
After taking the bar exam, Nixon became a lawyer in Whittier. But being a small community, there wasn't much work to be had and he wasn't making much money either, leading him to be oftentimes bored.
Then, in 1938, he was approached by two local businessmen who proposed that the three of them start an orange juice business. He agreed, formed a company named CitriFrost, and was elected president.
The idea behind the business was to produce freshly squeezed orange juice, add some sugar and gelatin, and then quick-freeze it. It was supposed to last indefinitely, and once defrosted, it would taste just like fresh orange juice.
Nixon gathered investments from mostly friends and family, added $1,000 of his own money, putting together a total of about $10,000 for the company's capital. But things were not to last, however, as CitriFrost ran into problems soon enough.
"Our product was good, the market was there, but we were doomed to fail for reasons beyond our control," he once recalled.
Ply film, the material in which the orange juice was packed, was becoming scarce around the country as the demand for it grew.
They nevertheless were able to get some good orders, but were unable to deliver as some their shipments broke down on transit.
Moreover, some disgruntled employees filed a lawsuit against the company, leading to Nixon and his fellow owners to pay them out of pocket.
In order to somehow save the company, he gave another $700, offered his legal services free of charge, had his father also work at the company for several weeks without pay, and finally ended up cutting and squeezing oranges himself day and night before finally closing the business down.
Friends of his recalled how distraught he was about the whole affair, particularly regarding his investors. Years later he even offered to pay them back.
Even though he was only in his mid-twenties, the whole affair affected him deeply and he declined any future offers of an executive position in a company. He Also Applied for the FBI.
As of 2014, the National Archives contains Richard Nixon's application to the bureau. It happened in 1937, one year before the orange juice business, when Nixon was 24-years-old and just before he was about to graduate from Duke University.
He was contacted for an interview one month after graduation, and even completed a physical exam at the request of the director of the FBI, J.
But as fate would have it, he didn't receive any response back and the rest is history. Well, not exactly – there are a few other things we do know.
In 1954, when Nixon was Vice President of the USA, he spoke at the annual FBI National Academy's graduation.
Hoover was also the one who introduced him on stage, saying that it was a pleasure for him to do so, knowing that the VP had previously applied.
The director also said during the graduation that Nixon, "Having already embarked upon the practice of law, the FBI's loss ultimately became the country's gain," referencing Nixon's not being part of the bureau.
But at a later party during his vice presidency, Nixon approached Hoover again, wanting to know why exactly he was never notified about his application.
Hoover then reopened his file at the FBI and saw that the Vice President was actually accepted, but his appointment was revoked one month later, in August 1937.
The reason for not hiring him, Hoover said, was because the bureau made some budget cuts that year.
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