Saturday, June 10, 2017

Youtube daily report w Jun 11 2017

Hello it's Kinoshita Yuka

today...

Jan !

from korea...

they send me a lot of the same snack

and this is what will eat !

it's pretzels

wasabi flavored pretzels !

this is my first time to eat it with wasabi flavor

because the package is on korean, i can't read it

i think they write "Freezels"

the same as the english !

Ah !

i can feel the wasabi aroma !

there is a lot of thing written here...

but unfortunately, i can't read it

this is how it looks like !

like a normal pretzels

mmmmmm !

the wasabi aroma is so strong

and it bite a little bit and this is so delicious

mmmmm !

and that goes so well with the pretzels

there is a lot inside

even in korea, they call it " wasabi" as well

mmmmm !

i like the wasabi

delicious !

and because it's tasty...

if you had a chance, try it as well !

to another time

bye bye

For more infomation >> 【Korean Snacks】 That's A Lot ! "Wasabi Pretzels" [CC Available] |Kinoshita Yuka - Duration: 1:15.

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SLR Magic Cine Lens 25mm f1.4 Review - Duration: 2:46.

Hi! I am Joseph Ezzeddine, and this is a review

of the SLR Magic 25mm Cine lens.

This lens was designed for Sony E-mount and FE mount cameras.

It is suitable for full-frame sensors and APS-C.

The great success of Sony cameras over the last two years

has prompted some manufacturers to develop E-mount lenses

to meet video professionals' needs.

SLR Magic announced this lens at the latest NAB Show in Las Vegas.

A fixed-focus Cine lens at 25mm with a maximum aperture of 1.4 f-stop

This large aperture makes it possible to film in low light conditions

and to have a nice blurred background.

In addition, the iris is composed of 13 blades

so it gives you a smooth and circular bokeh in background.

This lens produces a sharp image with remarkable acuity

and great precision in fine details.

For best optical performance and better edge sharpness,

I advise you to use it at aperture f2.8 or smaller.

Here is a comparison between several shots

taken at different apertures.

The diaphragm ring is manual.

The lens is totally mechanical.

And like all CINE type lenses, the focus ring is serrated

to be compatible with Follow Focus gears.

On a full-frame sensor, this lens provides a wide field of view,

the focal length is 25mm.

On an APS-C type sensor, the field of view is reduced

to 37mm due to the crop factor.

The minimum object distance is 25cm.

The lens is compact and weighs about 500g,

making it an ideal choice for use on a gimbal.

SLR Magic offers this lens at $ 400, $ 399 to be precise.

An affordable price for a CINE lens.

That's all about this lens.

Please share the video so everyone can enjoy it.

To see all my videos, I invite you to support my page on Patreon.

For more infomation >> SLR Magic Cine Lens 25mm f1.4 Review - Duration: 2:46.

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Что такое SARMs, Селективные модуляторы андрогенных рецепторов - Duration: 3:00.

For more infomation >> Что такое SARMs, Селективные модуляторы андрогенных рецепторов - Duration: 3:00.

-------------------------------------------

Opel Astra 1.0T EDITION (Navigatie, Parkeersensoren) - Duration: 0:59.

For more infomation >> Opel Astra 1.0T EDITION (Navigatie, Parkeersensoren) - Duration: 0:59.

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Opel Zafira Tourer 1.4T AUTOMAAT 140PK INNOVATION 7P. /Clima/Cruise/17"LM - Duration: 0:54.

For more infomation >> Opel Zafira Tourer 1.4T AUTOMAAT 140PK INNOVATION 7P. /Clima/Cruise/17"LM - Duration: 0:54.

-------------------------------------------

【Korean Snacks】 That's A Lot ! "Wasabi Pretzels" [CC Available] |Kinoshita Yuka - Duration: 1:15.

Hello it's Kinoshita Yuka

today...

Jan !

from korea...

they send me a lot of the same snack

and this is what will eat !

it's pretzels

wasabi flavored pretzels !

this is my first time to eat it with wasabi flavor

because the package is on korean, i can't read it

i think they write "Freezels"

the same as the english !

Ah !

i can feel the wasabi aroma !

there is a lot of thing written here...

but unfortunately, i can't read it

this is how it looks like !

like a normal pretzels

mmmmmm !

the wasabi aroma is so strong

and it bite a little bit and this is so delicious

mmmmm !

and that goes so well with the pretzels

there is a lot inside

even in korea, they call it " wasabi" as well

mmmmm !

i like the wasabi

delicious !

and because it's tasty...

if you had a chance, try it as well !

to another time

bye bye

For more infomation >> 【Korean Snacks】 That's A Lot ! "Wasabi Pretzels" [CC Available] |Kinoshita Yuka - Duration: 1:15.

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8 Signs You Are an Introvert - Duration: 11:33.

8 Signs You Are an Introvert

Introversion is a personality trait characterized by a focus on internal feelings rather than

on external sources of stimulation.

Introverts and extroverts are often viewed in terms of two extreme opposites, but the

truth is that most people lie somewhere in the middle.

While introverts make up an estimated 25 to 40 percent of the population, there are still

many misconceptions about this personality type.

It is also important to note that introversion is not the same things as social anxiety or

shyness.

Being an introvert does not mean that you are socially anxious or shy person.

In this video, I'm going to show you 8 Signs You Are an Introvert.

But before we start, make sure to like this video and subscribe our channel so you won't

miss any interesting updates in the future guys!

So, what Is an Introvert?

Introversion is one of the major personality traits identified in many theories of personality.

People who are introverted tend to be inward turning, or focused more on internal thoughts,

feelings and moods rather than seeking out external stimulation.

Introversion is generally viewed as existing as part of a continuum along with extroversion.

Introversion indicates one end of the scale, while extroversion represents the other end.

According to many theories of personality, everyone has some degree of both introversion

and extroversion.

However, people often tend to lean one way or the other.

Introverts tend to be more quiet, reserved, and introspective.

Unlike extroverts who gain energy from social interaction, introverts have to expend energy

in social situations.

After attending a party or spending time in a large group of people, introverts often

feel a need to "recharge" by spending a period of time alone.

Escaping somewhere to have time alone to recharge gives them the opportunity to process and

reflect on what they have learned.

What Causes Introversion?

In order to know why some people are introverted and some people are extroverted, it is important

to understand the role that your body's physiology plays.

The way that your body responds to the outside environment plays a critical role in determining

your level of extroversion and introversion.

Common Signs You Might Be an Introvert

Do you assume that you know who is an introvert and who isn't?

While you might think of an introvert as a shy wallflower who prefers to stay home alone

instead of socializing, introverts can actually come in many types with a wide variety characteristics.

There are certainly plenty of introverts who are socially reserved and who would prefer

to stay home and read a book rather than go to a big party, but there are also plenty

of introverts who enjoy socializing.

You might even be surprised to learn that many people who you think of as "social butterflies"

might actually be quite introverted.

Well, here are 8 Signs You Are an Introvert.

1.

Being Around Lots of People Drains Your Energy

Do you ever feel exhausted after spending time with a lot of people?

After a day interacting with others, do you often need to retreat to a quiet place and

have an extended amount of time all to yourself?

One of the major characteristics of this personality type is that introverts have to expend energy

in social situations, unlike extroverts who gain energy from such interactions.

That doesn't mean that all introverts avoid social events altogether.

Many introverts actually enjoy spending time around others, with one key caveat – introverts

tend to prefer the company of close friends.

While an extrovert might go to a party with the goal to meet new people, an introvert

intends to spend quality time talking to good friends.

2.

You Enjoy Solitude

As an introvert, your idea of a good time is a quiet afternoon to yourself to enjoy

your hobbies and interests.

A few hours alone with a good book, a peaceful nature walk or your favorite television program

are great ways to help you feel recharged and energized.

This does not mean that the average introvert wants to be alone all the time.

Many introverts love spending time with friends and interacting with familiar people in social

situations.

They key thing to remember is that after a long day of social activity, an introvert

will probably want to retreat to a quiet place to think, reflect, and recharge.

If having a few hours to be alone sounds like your idea of a good time, you just might be

an introvert.

3.

You Have a Small Group of Close Friends

One common misconception about introverts is that they don't like people.

While introverts typically do not enjoy a great deal of socializing, they do enjoy having

a small group of friends to whom they are particularly close.

Instead of having a large social circle of people they know only on a superficial level,

introverts prefer to stick to deep, long-lasting relationships marked by a great deal of closeness

and intimacy.

Researchers have found that people high in this trait tend to have a smaller group of

friends.

While extroverts generally have a wide circle of friends and acquaintances, introverts typically

choose their friends much more carefully.

Their closest relationships tend to be profound and significant.

They also prefer to interact with people on a one-on-one basis rather than in a large

group setting.

If your social circle tends to be small but very close, there's a pretty good chance you

are an introvert.

4.

People Often Describe You as Quiet and May Find It Difficult to Get to Know You

Introverts are often described as quiet, reserved, mellow and are sometimes mistaken for being

shy.

While some introverts certainly are shy, people certainly should not mistake an introvert's

reserve for timidity.

In many cases, people with this personality type simply prefer to choose their words carefully

and not waste time or energy on needless chit-chat.

If you are the quiet type and a bit reserved, you probably are an introvert.

5.

Too Much Stimulation Leaves You Feeling Distracted and Unfocused

When introverts have to spend time in activities or environments that are very hectic, they

can end up feeling unfocused and overwhelmed.

Extroverts, on the other hand, tend to thrive in situations where there is a lot of activity

and few chances of becoming bored.

According to at least one study, researchers have found that introverts tend to be more

easily distracted than extroverts, which is part of the reason why introverts tend to

prefer a quieter, less harried setting.

If you tend to feel overwhelmed in busy social situations, you probably tend to be an introvert.

6.

You Are Very Self-Aware

Because introverts tend to be inward-turning, they also spend a great deal of time examining

their own internal experiences.

If you feel like you have a very good knowledge and insight into yourself, your motivations,

and your feelings, you might be more of an introvert.

Introverts tend to enjoy simply thinking about and examining things in their own minds.

Self-awareness and self-understanding is important to introverts, so they often devote a great

deal of time to learning more about themselves.

This might involve exploring hobbies they enjoy, thinking about their lives, and reading

books that explore themes and topics that are important to them.

If you feel that you are self-aware and enjoy gaining deep knowledge about yourself, then

you might be more of an introvert.

7.

You Like to Learn By Watching

Where extroverts tend to prefer to jump right in and learn though hands-on experience, introverts

typically prefer learning through observation.

While extroverts typically learn through trial and error, introverts learn best by watching.

Introverts like to watch others perform a task, often repeatedly, until they feel that

they can replicate the actions on their own.

When introverts do learn from personal experience, they prefer to practice somewhere private

where they can build their skills and abilities without having to perform for an audience.

If you like to learn more by watching rather than doing, there is a chance that you have

a more introverted personality.

8.

You Are Drawn to Jobs That Involve Independence

As you might imagine, jobs that require a great deal of social interaction usually hold

little appeal to people high in introversion.

On the other hand, careers that involve working independently are often a great choice for

introverts.

For example, an introvert might enjoy working as a writer, accountant, computer programmer,

graphic designer, pharmacist, or artist.

Introversion and Shyness Are Not Synonymous

It is important to note that introversion does not necessarily equate with shyness.

In their book, The Development of Shyness and Social Withdrawal, authors Schmidt and

Buss write, "Sociability refers to the motive, strong or weak, of wanting to be with others,

whereas shyness refers to behavior when with others, inhibited or uninhibited, as well

as feelings of tension and discomfort."

Shyness indicates a fear of people or social situations.

Introverts, on the other hand, simply do not like to spend lots of time interacting with

other people.

However, they do appreciate being around people to whom they are close.

They find engaging in "small talk" tedious, but do enjoy having deep, meaningful conversations.

Introverts also tend to think about things before talking.

They want to have a full understanding of a concept before they voice an opinion or

try to offer an explanation.

Misconceptions About Introverts

In an excellent article in Atlantic Monthly, author Jonathan Rauch took on some of the

common myths and misconceptions about introverts.

While introverts are often labeled as shy, aloof, and arrogant, Rauch explains that these

perceptions result from the failure of extroverts to understand how introverts function.

"Extroverts have little or no grasp of introversion," Rauch suggests.

"They assume that company, especially their own, is always welcome.

They cannot imagine why someone would need to be alone; indeed, they often take umbrage

at the suggestion.

As often as I have tried to explain the matter to extroverts, I have never sensed that any

of them really understood."

According to estimates, extroverts outnumber introverts by about three to one.

Introverts often find that other people try to change them or even suggest that there

is something "wrong" with them.

Nothing could be further from the truth.

While introverts make up a smaller portion of the population, there is no right or wrong

personality type.

Instead, both introverts and extroverts should strive to understand each other's differences

and similarities.

Well, That's the 8 Signs You Are an Introvert.

What are your thoughts on this?

Are you happy as an extrovert or introvert?

Please share them in the comments below.

Really cool information isn't it?

Leave us a comment down below and let us know what you thought of this video.

Don't forget to give us account subs and watch other amazing videos on our channel.

Thanks for watching!

For more infomation >> 8 Signs You Are an Introvert - Duration: 11:33.

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【Hatsune Miku Append】Schwarzer Regen Vietsub+Lyrics【Vocaloid Original】(Có phụ đề) - Duration: 5:47.

For more infomation >> 【Hatsune Miku Append】Schwarzer Regen Vietsub+Lyrics【Vocaloid Original】(Có phụ đề) - Duration: 5:47.

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The Mysterious Bermuda Triangle Of China | Unsolved Mysteries - Duration: 9:45.

Many people have heard of the Bermuda Triangle, but what many others might not realize is

that this just one of many such predatory places that inhabit various areas around the

world.

One such place can be found in China, where there is a "doomed" spot where countless

mysterious disappearances have occurred.

From the early 1960s to 1980s nearly 200 boats sunk, 1,600 people declared missing and about

30 survivors suffered mental illness.

Many go down with no apparent cause at all, they are just sucked down into the abyss below. This is the mystery of Poyang Lake

Poyang Lake is located at Duchang County of Jiangxi Province and is one of the seven national

nature reserves.

At an average size of around 3,500 square kilometers (1,400 sq. mi), it is China's

largest freshwater lake, and is an essential stop off point for millions of migrating birds

every year, as well as the habitat for the very rare freshwater finless porpoise.

In addition to this rich biodiversity, the lake also has a rich history spanning centuries.

On the lake's northern shore is a temple called Laoye Temple.

Hence the locals call the waters near the temple the Laoye Temple waters.

The water area surrounding the Laoye Temple is also known as the "place of death,"

"devil horns," and the "East Bermuda Triangle,".

The water here has always been a mystery, and many people believe that a supernatural

mysterious force that violates the laws of physics must exist here.

Since recorded time, fishing, cargo and military vessels have disappeared from the lake without

a trace, a similarity to the Bermuda Triangle, but what deepens this mystery is an incredible

fact: both of these mysterious places are almost at the same latitude, between 28°22′-

29°45′ N latitude.

Accidents And Incidents happened One of the strangest such disappearances occurred

during World War II, when the Japanese invasion and occupation of China was in full swing.

On April 16, 1945, a Japanese boat sank in the Laoye Temple waters under totally clear

conditions.

The Japanese boat 'KOBE MARU' was a 2,000 ton Japanese cargo vessel, carrying 200 crews

and all the predatory antique, calligraphy, painting, gold and silver jewelry on its way

home from China to Japan.

Suddenly the weather turned foul, and a huge tide rose up, breaking the ship into pieces

and sucking it down into the depths of the lake.Sadly, none of the 200 crews on board

survived.

As soon as the ship was gone the weather cleared, the winds ceased, and the sun again shone

as if nothing had happened.

Afterward, the Japanese Navy allegedly sent a salvage team of seven divers to go recover

the ship's valuable cargo, yet only one of the divers survived.

The survivor was terrified after he took off his diving suit, he was allegedly speechless

and overcome with terror by something he had seen down in the depths.

The diver is said to have never divulged what had happened, and indeed is reported as having

been rendered morose, unresponsive, and driven insane by the mysterious ordeal.

None of the other divers or indeed any of the crew or even a scrap of the Kobe Maru

were ever seen again.

In the summer of 1946, after the Japanese had been expelled from China and the war was

over, the Nationalist government of China invited the accomplished American diver and

salvage expert, Edward Boer (or Bolton, depending on the source), out to Poyang to find the

remains of the Kobe Maru.

Treasure ships may be lost but they are rarely forgotten.

The spoils were sitting just 30 meters below the lake's surface, and by all accounts

should have been easy picking.

But after months of diving and the loss of two divers the search revealed nothing.

Boer (Bolton) himself declined to speak about what had transpired until he published the

account in the United Nation Environment News 40 years later.

He said that during a dive his team was assailed by a dazzling bright light and a high-pitched

screeching sound coming from the water's depths.

The lake, he claimed, felt as though it was shaking, and he was pulled into a vortex.

He momentarily went dizzy and lost consciousness, but was soon startled awake upon striking

a reef.

He hung on helplessly and watched as a gyrating bright light on the lake bottom sucked in

the other divers.

They were never seen again.

In the late 1970s, the people of this region built three dams in Poyang Lake.

The one they built near Laoye Temple was 2,000 feet long, 160 feet wide, and towered nearly

50 feet above the water's surface.

It disappeared one night without a sound or trace.

In the 1980s, the PLA's navy sent an expedition out to Laoye Temple to see what they could

find.

They came back empty handed.

Unsatisfied with this outcome, Captain Shen Dahai, chose to make one final dive.

He did not return.

Reports state that his body was found the following day in Changba Shan Lake, which

is 15 km away from and apparently not connected to the waters he dove into.

One clear day on Aug. 3, 1985, a total of 13 ships vanished without a trace in a single

day.

The few who have managed to come back to tell the tales are often beset with lost memories,

lost time, profound disorientation, and chronic mental illness, even stark raving insanity.

Boats have continued to go missing at Lake Poyang even up into the present day.

In 2001 a large cargo ship carrying sand was suddenly swamped by a sudden large wave in

otherwise calm conditions and sank without a trace.

One particularly strange recent case comes from March of 2010, in which a huge, 1,000

ton vessel suddenly sank on a clear, calm day near shore for no discernible reason.

Its wreckage was never located.

Many of the local fishermen claim that the weather could change abruptly without any

sign, storm could hit anytime and the wave could become very fiercely anytime.

Therefore, the fishermen would burn incense or hold ceremonies in order to pray to the

god to protect them before they proceed to the water.

Once upon a time On 1363, the navy of the Ming, under Zhu Yuanzhang,

the founding emperor of the Ming Dynasty (1368-1644), met the Han navy, commanded by Chen Youliang,

at the Poyang Lake.

This battle was one of the final battles fought in the fall of China's Mongol-led Yuan Dynasty

and by some definition, the largest naval battle in history.

According to some of the locals, at a time of the war, Zhu was losing the battle and

retreated to the lake shore.

There were no boats or any other means to cross the lake, but a giant turtle appeared

and helped Zhu across the lake.

After Zhu won the battle and became the emperor, Zhu designated the turtle as a general and

build a temple near the lake in memory of the turtle.

Locals believe that the turtle's spirit is what has been causing the abnormal phenomenon

to the lake.

Theories There have been numerous theories on what

is going on at Poyang Lake, ranging from the sensible to the absurd.

Few experts ran a series of infrared photographic test to the lake, and the outcome is, they

found out that there is a cliff of sand with an altitude of about 6600 ft, across from

east to west under the waters of the temple Laoye and they believe this is what leads

to the creation of swirling water below the lake.

The Whirlpool is very possible and strong enough to sink ships and a number of boats.

However, this theory still cannot explain why the wrecks of those sunken ships were

ever found.

Others have blamed spontaneous inter-dimensional portals, strange vortexes, earthbound black

holes, unexplained magnetic anomalies, freak lightning strikes, supernatural forces, or

of course alien abduction.

Many of the more fringe theories on the disappearances of Poyang Lake point to its location upon

the 30 degree north latitude.

This is significant because there are many ancient places of importance that are also

located here, such as the Pyramids of Egypt, the world's highest mountain Mount Everest

(27° 59′ N), the Dead Sea (31° 30′ N), the world's deepest undersea Mariana Trench

(11″21′ N) and ofcourse the infamous Bermuda Triangle itself.

This mystery as to what really is going on in the lake still remains to be demystified.

Thanks for watching I hope you found this video interesting, if you did please give

this video a thumbs up and subscribe to the channel for weekly content, have a good day

or night.

thank you once again for watching and I will see you guys in my next video.

For more infomation >> The Mysterious Bermuda Triangle Of China | Unsolved Mysteries - Duration: 9:45.

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Why is it so hard to make an HIV Vaccine - Duration: 10:09.

Why is it so hard to make an HIV Vaccine?

The history of HIV vaccine development has been marked by numerous setbacks and disappointments,

with each apparent "breakthrough" presenting even more challenges and hurdles to overcome.

Oftentimes it seems that for one step forward researchers take, an unforeseen obstacle sets

them back by one and even two steps.

In some ways, it's a fair assessment, given that we have yet to see a viable vaccine candidate.

On the other hand, scientists have, in fact, made enormous strides in recent years, gaining

greater insight into the complex dynamics of HIV infection and the body's response

to such infection.

So stirring are these advances that some now believe a vaccine may be possible within the

next 15 years (among them, Nobel Prize laureate and HIV co-discoverer Françoise Barré-Sinoussi).

Whether such a vaccine will be affordable, safe, and easy to administer and distribute

to a worldwide population remains to be seen.

But what we do know for sure is that a number of key barriers will need to be resolved if

any such candidate will ever move beyond the proof-of-concept stage.

3 Ways That HIV Hampers Vaccine Efforts

From the most fundamental standpoint, efforts to develop an HIV vaccine have been hampered

by the genetic diversity of the virus itself.

The replication cycle of HIV is not only fast (a little more than 24 hours) but is prone

to frequent errors, churning out mutated copies of itself which recombine into new strains

as the virus is passed from person to person.

Developing a single vaccine able to eradicate over 60 dominants strains as well as the multitude

of recombinant strains—and on a global level, becomes all the more challenging when conventional

vaccines can only protect against a limited number of viral strains.

Secondly, fighting HIV demands a robust response from the immune system, and this again where

systems fail.

Traditionally, specialized white blood cells called CD4 T-cells initiate the response by

signaling killer cells to the site of the infection.

Ironically, these are the very cells that HIV targets for infection.

By doing so, HIV hobbles the body's ability to defending itself as the CD4 population

is systematically depleted, resulting in the eventual breakdown of defenses called immune

exhaustion.

Finally, the eradication of HIV is thwarted by the virus' ability to hide from the body's

immune defenses.

Soon after infection, while other HIV is circulating freely in the bloodstream, a subset of virus

(called provirus) embeds itself in hidden cellular sanctuaries (called latent reservoirs).

Once inside these cells, HIV is shielded from detection.

Instead of infecting and killing the host cell, the latent HIV simply divides alongside

the host with its genetic material intact.

This means that even if free circulating HIV is eradicated, the "hidden" virus as the potential

to reactive and start infection anew.

Barriers to Overcome

It has become clear in recent years that overcoming these obstacles will demand a multi-pronged

strategy and that a single approach will unlikely achieve the goals needed to develop a sterilizing

vaccine.

The major components of this strategy would, therefore, have to address:

ways to neutralize the multitude of genetic HIV strains

ways to induce the appropriate immune response necessary for protection

ways to maintain the integrity of the immune systems

ways to clear and kill latent viruses

Progress is being made on many of these proposed strategies, with varying levels of effectiveness

and success, and can be roughly defined as follows:

Stimulating a "Broadly Neutralizing" Immune Response

Among people living with HIV, there is a subset of individuals known as elite controllers

who appear to have a natural resistance to HIV.

In recent years, scientists have begun to identify the specific genetic mutations they

believe confer to this natural, protective response.

Among them is a subset of specialized defensive proteins known as broadly neutralizing antibodies

(or b-NAbs).

Antibodies defend the body against a specific disease-causing agent (pathogen).

Most are non-broadly neutralizing antibodies, meaning that they only kill one or several

pathogen types.

By contrast, b-NAbs have the ability to kill a broad spectrum of HIV variants—up to 90%

in some cases—thereby limiting the virus' ability to infect and spread.

To date, scientists have yet to identify an effective means to induce a b-NAb response

to levels where it may be considered protective, and that such a response would likely take

months or even years to develop.

Complicating matters even further is the fact that we do not yet know if the stimulation

of these b-NAbs might be harmful—whether they might act against the body's own cells

and negate any benefit treatment might reap.

With that being said, a lot of focus is being placed on the direct inoculation of a b-NAbs

into people with established HIV infection.

One such b-NAb, known as 3BNC117, appears not only to block the infection of new cells

but to clear HIV-infected cells as well.

Such an approach might one day allow for an alternative or complementary approach to therapy

for people already infected with the virus.

Maintaining or Restoring Immune Integrity

Even if scientists were able to effectively induce the production of b-NAbs, it would

likely require a robust immune response.

This is considered a major challenge as that HIV itself causes immune depletion by actively

killing off "helper" CD4 T-cells.

Furthermore, the body's ability to fight HIV with so-called "killer" CD8 T-cells gradually

wanes over time as the body undergoes what is known as immune exhaustion.

During a chronic infection, the immune system will constantly regulate itself to ensure

that it is not either overstimulated (causing autoimmune disease) or understimulated (allowing

pathogens to spread unhindered).

Particularly during long-term HIV infection, underactivation can result as CD4 cells are

progressively wiped out and the body becomes less able to identify the pathogen (a situation

similar to that of patients with cancer).

When this happens, the immune system inadvertently "puts the brakes" on an appropriate response,

making it less and less capable of defending itself.

Scientists at Emory University have begun to explore the use of cloned antibodies called

ipilimumab, which may be able to "release the brakes" and reinvigorate CD8 T-cell production.

One of the more enthusiastically received pieces of research, currently in primate trials,

involves the use of the disabled "shell" of a common herpes virus called CMV into which

are inserted non-disease-causing fragments of S-I-V (the primate version of HIV).

When subjects are inoculated with the genetically altered CMV, the body responded to the "mock"

infection by accelerating CD8 T-cell production to fight off what they believe to be S-I-V.

What makes the CMV model particularly compelling is the fact that the herpes virus is not eliminated

from the body, like a cold virus, but keeps replicating on and on.

Whether this confers to long-term immune protection has yet to be determined, but it does provide

a compelling proof-of-concept.

Clearing and Killing Latent HIV

One of the greatest obstacles to developing an HIV vaccine is the speed by which the virus

is able to established latent reservoirs to evade immune detection.

It is believed that this can happen as quickly as four hours in case of anal sex transmission—moving

quickly from the site of infection to the lymph nodes, to up to four days in other types

of sexual or non-sexual transmission.

To date, we're neither entirely sure of even how extensive or large these reservoirs

may be nor their potential to effect viral rebound (i.e., a return of virus) in those

believed cleared of infection.

Some of the most aggressive pieces of research today involves a so-called "kick-kill" strategy

using stimulating agents that can "kick" latent HIV out of hiding, thereby allowing a secondary

agent or strategy to "kill" the newly exposed virus.

In this regards, scientists have had some success using drugs called HDAC inhibitors,

which have been traditionally used to treat epilepsy and mood disorders.

While studies have shown that newer HDAC drugs are capable of "waking" dormant virus, none

have yet been able to clear the reservoirs or even reduce their size.

Hopes are currently being pinned on the combined use of HDAC and other novel drug agents (include

PEP005, used to treat a type of sun-related skin cancer).

More problematic however, is the fact that H-D-A-C inhibitors can potentially cause toxicity

and the suppression of the immune responses.

As a result, scientists are also looking at a class of drugs, called TLA agonists, which

appear to be able to spur an immune response rather than "jarring" the virus out of hiding.

Early primate studies have been promising, with not only a measurable reduction of the

latent reservoirs but a significant increase in CD8 "killer" cell activation.

For more infomation >> Why is it so hard to make an HIV Vaccine - Duration: 10:09.

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Home Remedies For Loose Motion - Duration: 3:14.

Home remedies for loose motion.

Loose motion or diarrhea refers to the frequent passage of stools which are loose and watery.

Watery bowel movements are very common and are usually not very serious.

It may cause loss of water and minerals from the body.

Loss of water from the body can cause dehydration.

It also results in weakness, loss of appetite; stomach pain etc.

To reduce the frequency of loose motion and bring your bowel movements to regularity,

there are many simple and easy home remedies.

So please like share and subscribe our channel for more videos.

1.

Honey.

Honey is a natural medicine that can cure a lot of health problems and is very effective

in fighting loose stools.

Take a teaspoon of fresh and pure honey.

Add half a teaspoon of cinnamon powder and the pure honey in a glass of warm water.

Mix it well.

Drink this water on empty stomach early in the morning.

Then repeat the same at least two times in the day to cure your bladder infection.

You will see visible results within two days.

2.

Dry Ginger Powder.

Ginger has antifungal and antibacterial properties and also helps in soothing the stomach pains

apart from improving digestion.

It is an excellent ingredient to take for loose motions.

Add half a teaspoon of dry ginger powder in a cup of buttermilk.

Mix it well and drink this buttermilk three to four times a day.

Within 2 days, you are sure to see a considerable reduction in diarrhea.

3.

Raw Papaya.

Papaya is found to be effective in treating loose motions.

It will help in easing stomach pain as well as reduce stomach cramps.

Grate a raw papaya and put in a bowl that contains three cups of water.

Boil the raw papaya in water for about 10 minutes.

Strain the water and drink it once it becomes warm.

Drink this two to three times a day till you feel a reduction in loose motion.

4.

Turmeric.

Turmeric has antibiotic nature helps fight bacteria that cause this annoying problem.

This spice can even help keep your system working properly.

Mix half a teaspoon of turmeric powder in a glass of warm water.

Mix it well and drink it fast, as the powder tends to quickly settle on the bottom.

Drink this 2 or 3 times a day.

5.

Mustard Seeds.

Mustard seeds are found to have certain antibacterial properties that will be effective in treating

loose stools.

Add � teaspoon of mustard seeds in a tablespoon of water.

Keep it there for one hour.

Now drink this water like you take a regular oral tonic.

Repeat it for two to three times a day to get rid of loose stools.

For more infomation >> Home Remedies For Loose Motion - Duration: 3:14.

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Derek Brunson destroys Dan Kelly with brutal first round knockout - Duration: 2:23.

Brunson earns his fifth UFC victory by knockout or TKO and he was quick to call for a matchup against submission specialist Antonio Carlos Junior

It was only a week ago where Carlos Junior won his most recent fight and asked for Brunson by name so it appears he might get his wish.

"I'm working my way towards that title shot. Some guy just got a victory last week [Antonio Carlos Junior]

I don't really care about rankings," Brunson said. "You talked trash, let's do it."

Following two straight losses, Derek Brunson had something to prove as he stepped into the Octagon to face Dan Kelly in the co-main event at UFC Fight Night in New Zealand.

Brunson needed less than five minutes and one devastating left hand to get back on track as he finished Kelly in emphatic fashion.

The 33-year old North Carolina native was still feeling the sting from his last fight when he lost a very close

controversial decision to former middleweight champion Anderson Silva so he took out his frustrations on Kelly.

Brunson had worked tirelessly on his striking in the lead up to this fight and he quickly established his right jab

which set up his best power punch coming from the left hand.

Like clockwork, Brunson set up his punches and unloaded a massive left hand that came over the top and connected flush on Kelly's jaw before he crumbled to the mat in a heap

Brunson quickly followed up with a few more shots as the referee rushed into stop the fight before Kelly could take too much damage

The end came at 1:16 into the first round.

For more infomation >> Derek Brunson destroys Dan Kelly with brutal first round knockout - Duration: 2:23.

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Hülb - Bunaltıcı Reklamlar / Soul Sucking Commercials / Comerciales de Succión del Alma - Duration: 0:32.

Mom said I need not to idle around much on the way to the market.

Whenas I love candy, chocolate and chips.

What about thou?..

Do you love chips?..

Chocolate bars, chips, peppermint drops!

But I fondle them for a good number of minutes!..

I am sorry mommy...

Chocolate bars, chips, peppermint drops!

Yet, I love their taste too much!

Commercials!

Chocolate bars, chips, peppermint drops!

Their flavor on the commercials was heavenly...

I can't keep away from them!

Chocolate bars, chips, peppermint drops.

I cannot! keep away from! them!..

What about thou?.. Can you keep away from them?..

For, everything of the commercials is better...

My mom in the commercials would state this, too...

Eat! Eat and eat!

Drink! Drink and drink!

For more infomation >> Hülb - Bunaltıcı Reklamlar / Soul Sucking Commercials / Comerciales de Succión del Alma - Duration: 0:32.

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Ityadi ইত্যাদি Hanif Sanket Jessore Episode Era Hasan - Duration: 3:06.

For more infomation >> Ityadi ইত্যাদি Hanif Sanket Jessore Episode Era Hasan - Duration: 3:06.

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Say Goodbye to Underarm Odor Forever With These 10 Effective Home Remedies! - Duration: 4:10.

Say Goodbye to Underarm Odor Forever With These 10 Effective Home Remedies!

Everybody wants to protect the body from excessive sweating and underarm odor.

Perfumes and deodorants are far away from the best choice.

If you don't want to chemical based products or if you have tried using deodorant eliminate

underarm odor anymore, you should definitely try these powerful natural ways to get rid

of it.

Stop Shaving: Although it may seem unappealing, body hair

plays an important role for your body because it absorbs the moisture which makes good grounds

for bacteria proliferation and underarm odour.

Shaving your underarm hair creates a number of issues like skin irritation, because the

razor makes way for bacteria to thrive.

Depilatory creams, shaving creams and other lotions, which also irritate the skin, give

pretty much the same effect as razors.

Lemon: Due to its ability to balance the pH level

of the skin, this citrus fruit can be very helpful when it comes to eliminating underarm

odour.

Simply put a lemon slice on your armpit, let it act for fifteen minutes, and go fresh for

the day.

Lemon can also be used for removing household odours.

Alcohol: Alcohol is a natural disinfectant that can

be used for many purposes, including getting rid of underarm odor.

Be sure to use an odorless alcohol like vodka so that you don't smell like alcohol.

When you are getting dressed mist some alcohol under your arms and let it dry.

It will kill bacteria and odor.

Apple Cider Vinegar: In a spray bottle mix a little water, ACV,

and some lemon juice.

Before you get dressed, spray that under your arms in the morning.

You can also keep spray bottle at work if you need to reapply during the day.

Your skin will be kept from bacteria that causes odor and will be kept balanced.

Natural Soap: You can eliminate underarm odor by cleaning

the whole body (armpits) with natural soap.

Buy natural handmade soap from goat's milk if you do not want to make your own soap (castile

soap).

Baking Soda: Most of you use baking soda to get rid of

odors in your laundry or fridge, so why don't you use to eliminate underarm odor too.

This substance is natural and gentle.

Make a mixture between a little corn starch and a little baking soda and keep your skin

dry and smell fresh all day.

Use it according to your needs before get dressed.

Talc: Natural talc will stop moisture from allowing

bacterial growth and that will stop odor before it starts.

After you have washed with natural soap dry your armpits and apply some talc.

Reapply throughout the day so that bacteria has no chance to grow.

Tea Tree Oil: Tree oils can solve various skin problems

including odor.

It is known for its antibacterial and antifungal properties, and people were fully aware of

them for hundreds of years.

Make a mixture out of few drops of tea tree oil and some natural rosewater, and then spray

it onto the underarm area.

This simple trick can help you eliminate the odor instantly.

Hydrogen Peroxide: Hydrogen peroxide has a number of uses and

one of them is eliminating underarm odour.

Just mix hydrogen peroxide with water or natural rose water, and you get a healthy and natural

way of eliminating the unwanted smell under your arms.

Alum: Alum is a great natural deodorant.

Just wet a piece of alum and rub it under your arms and it will stop underarm odor.

For more infomation >> Say Goodbye to Underarm Odor Forever With These 10 Effective Home Remedies! - Duration: 4:10.

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7 ways to attract women - how to attract females | animated video - Duration: 3:03.

No.1, Smell amazing.

Just like you love a girl who smells like a perfect princess, girls love it when men

smell amazing too.

You can do this by first keeping your body clean, and then adding a nice scent.

This can be as simple as getting a really nice smelling deodorant.

If you want to go a bit further, you can try cologne or body sprays.

Just make sure that the smell is subtle, and that you put it on correctly.

She doesn't want you to smell like you bathed in Axe.

No.2, Maintain your body.

Just like guys usually prefer a fairly skinny girl, girls usually prefer decently fit guys.

Don't feel like you have to look like Arnold, because she won't care so much whether you

have a six pack or not.

just get yourself to a point where you're healthy and comfortable

No.3, A sense of humour.

If you can make a girl laugh and show you're fun to be around, she'll associate positive

feelings with you.

Concentrate on showing your funny side

No.4, Give girls their freedom.

Girls don't want to date someone who's really clingy, or controlling.

If you have girl friends that you're hoping to catch the eye of, show them that you're

perfectly happy to go do your own thing without them.

Don't annoy them by constantly asking to hang out, don't ask to go everywhere with them,

don't try to trap them in a corner, when you want to talk, Show girls that they are free

to go where they want and do what they want, and if they want a buddy along for the ride,

you're there for them.

No.5, Show your desire for her.

The desire of being desired by another man is extremely sexy for a girl.

Unleash the beast!

Be the man who goes after what he wants.

No.6, Keep your voice low and speak slowly.

A calming deep voice is very seductive.

Speak slowly and accentuate your words like you're telling a story to captivate her

attention.

No.7, Be exciting.

Don't be the guy who sits at home all weekend, eating Funyuns and playing video games.

There's nothing wrong with being introverted, but you still need to spend your time doing

exciting things.

If you're introverted, start writing a book or teaching yourself an art.

If you're more comfortable talking to people and getting outside, go do those things.

Join a club, go hiking, volunteer, whatever.

Just make your life about something.

You want to have something to talk to girls about

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